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Nivolumab and ipilimumab combination could lead to effective treatment options for SCLC patients

Small cell lung cancer (SCLC) represents approximately 14 percent of all types of lung cancer. Many patients with SCLC respond to initial chemotherapy; however, they eventually relapse and develop progressive disease that has no effective treatment options.

2 Jun 2016

TxCell, LIED collaborate to develop CAR-Treg-based cellular immunotherapy for bullous pemphigoid

TxCell SA, a biotechnology company developing innovative, personalized cellular immunotherapies using regulatory T cells to treat severe chronic inflammatory and autoimmune diseases, today announces the signature of a strategic R&D collaboration agreement with the Lübeck Institute of Experimental Dermatology, a leading institution in the field of translational research on skin blistering diseases, part of the University of Lübeck in Germany.

2 Jun 2016

New NPS MedicineWise program aims to help health professionals improve diabetes management

A new educational program aims to help health professionals keep up to date with the latest evidence on second and third line medicines for lowering blood glucose.

2 Jun 2016

Scientists reveal how ER+ breast cancer uses cholesterol-based molecule to evade anti-hormone treatments

New research funded by Breast Cancer Now has identified how the most common breast cancers could be using a cholesterol-based molecule to evade standard anti-hormone treatments, causing patients’ disease to return.

2 Jun 2016

GET.ON online training course can effectively reduce depression risk

Inspired by promising tests of web-based health intervention measures, the researchers aimed to find out whether the risk of developing depression could be reduced by a six-week online training course called GET.ON. GET.ON is based on established therapy methods involving systematic problem solving and behavioural activation.

2 Jun 2016

Enzyme protein neutrophil elastase may be key contributor to development of muscular dystrophy

Scientists at the University of Liverpool have discovered that muscle cells affected by muscular dystrophy contain high levels of an enzyme that impairs muscle repair. This finding provides a new target for potential drug treatments for the disease, which currently has no cure.

2 Jun 2016

Nonprofits partner to raise awareness of scleroderma

If you've ever silently questioned someone wearing mittens on a warm spring day, the answer may be scleroderma. Or wondered why a woman, who otherwise appeared middle-aged, wore a face as wrinkle-free as her teenage daughter. The answer may be scleroderma.

2 Jun 2016

Excess phosphates in foods may lead to abnormally high blood pressure

Excess consumption of phosphate over-activates nerves that raise blood pressure, leading to abnormally high blood pressure, a new study in the American Journal of Physiology—Regulatory, Integrative and Comparative Physiology reports.

2 Jun 2016

Multiple cell and gene therapies can enhance cardiac function in mice modeled with MI

Researchers at the University of Utah compared the therapeutic potential of umbilical cord-derived sub-epithelial cells (UC-SECs), bone marrow-derived mesenchymal stem cells (BM-MSCs) and induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) -- all derived from human tissue -- along with genes (S100a1 and SDF-1a) and growth factor (VEGF165) to evaluate how injected biologics might enhance cardiac function in mice modeled with myocardial infarction (MI; commonly referred to as heart attack).

2 Jun 2016

$CD34+ cell therapy improves angina frequency in no option patients with class III/IV angina refractory$

CD34+ cell therapy improves angina frequency in no option patients with class III/IV angina refractory

A two-year, multi-center clinical study with 167 patients with class III-IV refractory angina randomized to low and high dose CD34+ cells or placebo has revealed that patients who received either a high or low dose of CD34 -- a member of a family of proteins that have an impact on vascular-associated tissue -- cells had a significant reduction in angina frequency over patients who received placebo.

2 Jun 2016

Interventions for breast cancer patients show benefits based on women’s stress levels

Is a couples' support group or an enhanced couples' group therapy intervention with skill instruction more effective for helping women diagnosed with early stage breast cancer? According to research from an investigator at Rutgers Cancer Institute of New Jersey and colleagues from other facilities across the country, neither intervention is more dominant, but each has its own benefits depending on the stress level of the patient.

2 Jun 2016

Just one stroke risk factor signals anticoagulation need in AF

The risk of stroke or systemic embolism is significantly increased in atrial fibrillation patients with just one risk factor apart from gender, say researchers.

2 Jun 2016

New roadmap can help guide researchers to speed up biomarker-based research on Alzheimer's disease

Biomarkers could revolutionise the early detection of and therapy for Alzheimer's disease. However, experts attending the Congress of the European Academy of Neurology in Copenhagen criticized that the big breakthroughs are slow in coming because of a lack of priorities in research.

1 Jun 2016

Women less likely to receive good anticoagulant therapy for AF-related stroke, say researchers

Female atrial fibrillation patients are less likely than their male counterparts to receive blood thinning therapies to prevent stroke, say University of Cincinnati College of Medicine researchers.

1 Jun 2016

Review sheds new light on link between smoking habits and psoriasis

Psoriasis: Targets and Therapy has published the review "Psoriasis and smoking: links and risks". As corresponding author Professor Luigi Naldi says "The review in Psoriasis: Targets and Therapy throws new light on the relation between smoking habits and psoriasis.

1 Jun 2016

Clinical trial to test safety, efficacy of Roswell Park-developed SurVaxM in multiple myeloma patients

An immune-based therapy developed at Roswell Park Cancer Institute is moving forward with its third clinical trial. The early-stage clinical trial will assess whether SurVaxM — a cancer vaccine developed at Roswell Park — is a safe and effective treatment option for patients with multiple myeloma, a rare type of blood cancer.

1 Jun 2016

Ocaliva drug gets FDA approval for primary biliary cholangitis treatment

On Friday, May 27, the U.S. Food and Drug Administration granted accelerated approval for Ocaliva (obeticholic acid) for the treatment of primary biliary cholangitis (PBC) in combination with ursodeoxycholic acid (UDCA) in adults with an inadequate response to UDCA, or as a single therapy in adults unable to tolerate UDCA.

1 Jun 2016

New research in mice provides better understanding of how HD begins and develops

Mice transplanted with cells grown from a patient suffering from Huntington's disease (HD) develop the clinical features and brain pathology of that patient, suggests a study published in the latest issue of Acta Neuropathologica by CHA University in Korea, in collaboration with researchers at Université Laval in Québec City, Canada.

1 Jun 2016

Rome IV criteria helps diagnose, treat gastrointestinal conditions in children

A child feels nauseated all the time, but no medical test can find what is wrong. Or a child vomits regularly, but there's no illness or eating disorder to explain it. These, and other stomach and bowel-related problems with no obvious causes, are called functional gastrointestinal disorders.

1 Jun 2016

Altered circadian somatostatin expression linked to bipolar disorder

Results of the first study of its kind to link abnormalities in circadian rhythms to changes in specific neurotransmitters in people with bipolar disorder will be published this week in the journal Biological Psychiatry.

1 Jun 2016

Therapy News and Research

Nivolumab and ipilimumab combination could lead to effective treatment options for SCLC patients

TxCell, LIED collaborate to develop CAR-Treg-based cellular immunotherapy for bullous pemphigoid

New NPS MedicineWise program aims to help health professionals improve diabetes management

Scientists reveal how ER+ breast cancer uses cholesterol-based molecule to evade anti-hormone treatments

GET.ON online training course can effectively reduce depression risk

Enzyme protein neutrophil elastase may be key contributor to development of muscular dystrophy

Nonprofits partner to raise awareness of scleroderma

Excess phosphates in foods may lead to abnormally high blood pressure

Multiple cell and gene therapies can enhance cardiac function in mice modeled with MI

CD34+ cell therapy improves angina frequency in no option patients with class III/IV angina refractory

Interventions for breast cancer patients show benefits based on women’s stress levels

Just one stroke risk factor signals anticoagulation need in AF

New roadmap can help guide researchers to speed up biomarker-based research on Alzheimer's disease

Women less likely to receive good anticoagulant therapy for AF-related stroke, say researchers

Review sheds new light on link between smoking habits and psoriasis

Clinical trial to test safety, efficacy of Roswell Park-developed SurVaxM in multiple myeloma patients

Ocaliva drug gets FDA approval for primary biliary cholangitis treatment

New research in mice provides better understanding of how HD begins and develops

Rome IV criteria helps diagnose, treat gastrointestinal conditions in children

Altered circadian somatostatin expression linked to bipolar disorder

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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