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European Commission approves extended indication for Amgen's Kyprolis (carfilzomib) for the treatment of relapsed multiple myeloma patients

Amgen has announced that the European Commission (EC) has approved a variation to the marketing authorization for Kyprolis® (carfilzomib) to include use in combination with dexamethasone alone for adult patients with multiple myeloma who have received at least one prior therapy. The extended indication marks the second approval for Kyprolis by the EC in less than a year.

6 Jul 2016

Self-monitoring or self-management of anticoagulation therapy can help reduce thromboembolic events

Patients on long-term anticoagulation therapy who test their own blood-clotting time from home and continue to be managed by their GP are significantly less likely to experience a thromboembolic event, according to Oxford University researchers.

6 Jul 2016

JACC publishes pivotal data on Tryton’s dedicated coronary bifurcation stent, results submitted to FDA

Tryton Medical, Inc., the leading developer of stents designed to treat coronary bifurcation lesions, today announced that results from the Tryton Confirmatory Study of the company’s Side Branch Stent have been published in JACC Cardiovascular Interventions.

6 Jul 2016

Health care resource use and costs of H.P. Acthar® gel for multiple sclerosis relapse

Mallinckrodt plc, a leading global specialty biopharmaceutical company, today announced new retrospective health economic data on H.P. Acthar® Gel (repository corticotropin injection; RCI), which may be an option for the management of multiple sclerosis (MS) relapses.

6 Jul 2016

Quantum Genomics initiates Phase IIa trial for heart failure

Quantum Genomics, a biopharmaceutical company with the mission of developing new therapies for unmet medical needs in the field of cardiovascular diseases, today announced the initiation of its Phase IIa multicentric clinical trial of GQC101, entitled QUID HF (QUantum Genomics Incremental Dosing in Heart Failure), for the treatment of patients with chronic heart failure. The first three clinical centres of the European trial have been opened in France and Norway.

6 Jul 2016

Necitumumab drug shows minor added benefit in patients with metastatic NSCLC

The monoclonal antibody necitumumab has been approved since February 2016 for the treatment of patients with locally advanced or metastatic epidermal growth factor receptor (EGFR) expressing non-small cell lung cancer (NSCLC) who have not received prior chemotherapy for this condition.

5 Jul 2016

Ticagrelor drug shows minor added benefit for patients with history of myocardial infarction

The German Institute for Quality and Efficiency in Health Care assessed the added benefit of ticagrelor for patients with acute coronary syndrome already in 2011 in its very first dossier assessment, just after the Act on the Reform of the Market for Medicinal Products had come into force.

5 Jul 2016

FDA approves Absorb GT1 BVS to treat coronary artery disease

The U.S. Food and Drug Administration today approved the first fully absorbable stent to treat coronary artery disease.

5 Jul 2016

Major improvements to portable oxygen concentrators from CAIRE Inc.

CAIRE Inc., a Chart Industries Company and the global oxygen market leader, has made major improvements to their AirSep® FreeStyle® and FreeStyle 5™ portable oxygen concentrators.

5 Jul 2016

Celltrion Healthcare commits to develop lab tests for evidence-based decision-making in anti-TNF treatment

Celltrion Healthcare, a global biopharmaceutical company, today announced its research commitment to develop laboratory tests that will determine both drug and anti-drug antibody levels in the blood, enabling physicians to identify when patients on an anti-tumour necrosis factor drug require a change of dose or a switch to a different treatment in the class.

5 Jul 2016

Argentine Tango dance holds potential to reduce fall risk among cancer survivors with neuropathy

Dance as a form of therapy - specifically Argentine Tango -- has the potential to significantly improve balance and reduce falls risk among cancer patients experiencing peripheral neuropathy, according to new research conducted by a multidisciplinary research team at The Ohio State University.

5 Jul 2016

LouLou Foundation, ODC announce 11 new grants for research on CDKL5 deficiency

LouLou Foundation and the Orphan Disease Center (ODC) in the Perelman School of Medicine at the University of Pennsylvania are pleased to announce the award of 11 new research grants into CDKL5 deficiency - a rare X-chromosome-linked genetic disorder that causes severe neuro-developmental impairment and early-onset, difficult-to-control seizures.

5 Jul 2016

Scientists identify genetic mutations linked to synchronous colorectal cancers

Researchers have identified genetic mutations affecting the immune system which may lead to the development of more than one bowel tumour at the same time. Understanding how these cancers develop could improve targeting of therapies, according to the study published in Nature Communications.

5 Jul 2016

FIB-4 index predicts HBV-related HCC

Japanese researchers reveal an association between elevated FIB-4 index 24 weeks after the initiation of nucleos(t)ide analogue therapy and the development of hepatocellular carcinoma in patients with chronic hepatitis B virus infection.

4 Jul 2016

TDF reduces vertical HBV transmission

The mother-to-child transmission of hepatitis B virus is reduced with tenofovir disoproxil fumarate treatment during the third trimester in pregnant chronic HBV patients with a high viral load, show the findings of a trial conducted in China.

4 Jul 2016

New mouse model reveals how Alzheimer's causes dementia

Using a novel, newly developed mouse model that mimics the development of Alzheimer's disease in humans, Johns Hopkins researchers say they have been able to determine that a one-two punch of major biological "insults" must occur in the brain to cause the dementia that is the hallmark of the disease.

4 Jul 2016

Immunotherapy in conjunction with drugs could be effective in treating pancreatic cancer

While immune therapy has proven effective in treating certain types of cancer, especially lung cancer and melanoma, tumors of the pancreas remain among the most difficult to treat and, so far, are impervious to immune-based therapies.

4 Jul 2016

Adjunct therapy with human growth hormone in IVF shows no apparent benefit in women

Despite its occasional use as an adjunct in IVF, human growth hormone appears of little benefit to women having difficulty conceiving.

4 Jul 2016

TAILOR study shows treatment with Erbitux plus FOLFOX improves survival in RAS wild-type mCRC patients

Merck, a leading science and technology company, will present data at the ESMO 18th World Congress on Gastrointestinal Cancer from the pivotal Phase III TAILOR study in patients from China, the first prospective trial to evaluate an anti-EGFR antibody in the first-line therapy of patients with RAS wild-type metastatic colorectal cancer (mCRC).

4 Jul 2016

Merck partners with University of Nairobi to start medical oncology fellowship program for African doctors

Merck, a leading science and technology company, today announced to start the first Merck Africa Medical Oncology Fellowship Program for Sub-Saharan African countries in partnership with University of Nairobi, Kenya.

4 Jul 2016

Therapy News and Research

European Commission approves extended indication for Amgen's Kyprolis (carfilzomib) for the treatment of relapsed multiple myeloma patients

Self-monitoring or self-management of anticoagulation therapy can help reduce thromboembolic events

JACC publishes pivotal data on Tryton’s dedicated coronary bifurcation stent, results submitted to FDA

Health care resource use and costs of H.P. Acthar® gel for multiple sclerosis relapse

Quantum Genomics initiates Phase IIa trial for heart failure

Necitumumab drug shows minor added benefit in patients with metastatic NSCLC

Ticagrelor drug shows minor added benefit for patients with history of myocardial infarction

FDA approves Absorb GT1 BVS to treat coronary artery disease

Major improvements to portable oxygen concentrators from CAIRE Inc.

Celltrion Healthcare commits to develop lab tests for evidence-based decision-making in anti-TNF treatment

Argentine Tango dance holds potential to reduce fall risk among cancer survivors with neuropathy

LouLou Foundation, ODC announce 11 new grants for research on CDKL5 deficiency

Scientists identify genetic mutations linked to synchronous colorectal cancers

FIB-4 index predicts HBV-related HCC

TDF reduces vertical HBV transmission

New mouse model reveals how Alzheimer's causes dementia

Immunotherapy in conjunction with drugs could be effective in treating pancreatic cancer

Adjunct therapy with human growth hormone in IVF shows no apparent benefit in women

TAILOR study shows treatment with Erbitux plus FOLFOX improves survival in RAS wild-type mCRC patients

Merck partners with University of Nairobi to start medical oncology fellowship program for African doctors

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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