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New strategy treats fatal autoimmune disease without outward off-target effects

In a study with potentially major implications for the future treatment of autoimmunity and related conditions, scientists from the Perelman School of Medicine at the University of Pennsylvania have found a way to remove the subset of antibody-making cells that cause an autoimmune disease, without harming the rest of the immune system.

4 Jul 2016

Novel blood coagulation analyzer may help detect stroke risk in AF patients

Researchers at Tokyo Medical and Dental University show that an analyzer recently developed to measure blood coagulability has the sensitivity to detect hypercoagulatibility associated with stroke risk in those without atrial fibrillation

4 Jul 2016

Novel anti-interleukin 1-alpha antibody shows promise in treating advanced colorectal cancer patients

A novel anti-interleukin 1-alpha antibody has shown a significant impact on symptoms, and a high level of safety and tolerability in patients with advanced colorectal cancer, according to phase III data presented at the European Society for Medical Oncology's 18th World Congress of Gastrointestinal Cancer in Barcelona, Spain.

4 Jul 2016

Scientists develop light-activated injectable device to stimulate nerve cells

In the campy 1966 science fiction movie "Fantastic Voyage," scientists miniaturize a submarine with themselves inside and travel through the body of a colleague to break up a potentially fatal blood clot. Right. Micro-humans aside, imagine the inflammation that metal sub would cause.

4 Jul 2016

Neoadjuvant endocrine therapy 'a reasonable option' for ER-positive breast cancer

Endocrine therapy should be reconsidered as a potential option in the neoadjuvant setting for localised oestrogen receptor-positive breast cancer, say the authors of a meta-analysis.

1 Jul 2016

New software tool could help routinely measure brain atrophy in MS patients

The loss of brain tissue, called brain atrophy, is a normal part of aging, but multiple sclerosis (MS) accelerates the process.

1 Jul 2016

Scientists develop new vaccine to stimulate both innate and specific adaptive response

Though a variety of immunotherapy-based strategies are being used against cancer, they are often hindered by the inability of the immune response to enter the immunosuppressive tumor microenvironment and to effectively mount a response to cancer cells.

1 Jul 2016

Implementation science may help prevent mother-to-child HIV transmissions

An emerging field, known as implementation science, may help reduce the nearly 150,000 instances of mother-to-child HIV transmissions that occur annually around the world, mostly in developing countries. c

1 Jul 2016

Scientists discover new way to predict risk for delayed recovery in children with AML

The chemotherapy treatments necessary to treat Acute Myeloid Leukemia (AML) in children can be grueling on the body, and can cause health-related complications during therapy, as well as long down the road after remission.

1 Jul 2016

Targeted molecular therapy reduces initial development of NAFLD in mice

Researchers report in the journal Cell Reports a targeted molecular therapy that dramatically reduces the initial development of Non Alcoholic Fatty Liver Disease (NAFLD) in laboratory mouse models of the disease.

1 Jul 2016

Virtual reality games fail to outplay card and ball games in stroke rehabilitation

Researchers have found inexpensive recreational activities such as playing cards or ball games are as effective add-on therapies to conventional stroke rehabilitation as virtual reality interventions.

1 Jul 2016

Sheffield researchers identify novel function of C9orf72 protein linked to ALS and FTD

Scientists from the University of Sheffield have discovered a novel function of the C9orf72 protein which is linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) - giving a new insight into the most common genetic cause of the degenerative diseases.

1 Jul 2016

Itaconate can suppress pro-inflammatory activity of macrophages

An international group of scientists from US, Canada, Germany and Russia has revealed a substance produced in humans that can suppress the pro-inflammatory activity of macrophages - specific cells of immune system.

1 Jul 2016

Philips introduces DreamMapper app and website in the UK for people living with sleep apnoea

Royal Philips has today announced the UK launch of the DreamMapper app and website, designed to assist people living with sleep apnoea to improve treatment adherence by providing tools and real time tracking and analysis of their positive airway pressure (PAP) therapy.

30 Jun 2016

Researchers develop in vitro model system for investigating etiology of NAFLD

Researchers from the Institute for Stem Cell Research and Regenerative Medicine at the University Clinic of Düsseldorf have established an in vitro model system for investigating nonalcoholic fatty liver disease (NAFLD).

30 Jun 2016

Group art therapy shows promise in treating Syrian refugee children with psychological problems

Group art therapy shows promise in reducing a wide range of psychological symptoms commonly experienced by refugee children, according to a pilot study of Syrian refugee children living in Turkey, published in the journal, Vulnerable Children and Youth Studies.

30 Jun 2016

Everolimus combined with standard R-CHOP therapy shows promise in treating DLBCL patients

The targeted therapy everolimus may be safely combined with R-CHOP for new, untreated diffuse large B-cell lymphoma according to the results of a pilot study by Mayo Clinic researchers published in the Lancet Haematology.

30 Jun 2016

Scientists develop new nonradioactive method to determine telomere length

UT Southwestern Medical Center cell biologists have identified a new method for determining the length of telomeres, the endcaps of chromosomes, which can influence cancer progression and aging.

30 Jun 2016

New AAV 3.0 program to create next-generation viral vectors for better treatment of inherited diseases

The Perelman School of Medicine at the University of Pennsylvania has launched a new program, called AAV 3.0, to create new viral vectors to find quicker and better treatments for an array of diseases. James M. Wilson, MD, PhD, a professor of Medicine and director of the Orphan Disease Center, will lead an interdisciplinary team of over 30 scientists to create this new technology platform with support provided by the University of Pennsylvania Health System.

30 Jun 2016

Researchers reveal novel mechanism by which viral protein VII suppresses immune alarm signals

Viruses must avoid a host's immune system to establish successful infections—and scientists have discovered another tool that viruses use to frustrate host defenses.

30 Jun 2016

Therapy News and Research

New strategy treats fatal autoimmune disease without outward off-target effects

Novel blood coagulation analyzer may help detect stroke risk in AF patients

Novel anti-interleukin 1-alpha antibody shows promise in treating advanced colorectal cancer patients

Scientists develop light-activated injectable device to stimulate nerve cells

Neoadjuvant endocrine therapy 'a reasonable option' for ER-positive breast cancer

New software tool could help routinely measure brain atrophy in MS patients

Scientists develop new vaccine to stimulate both innate and specific adaptive response

Implementation science may help prevent mother-to-child HIV transmissions

Scientists discover new way to predict risk for delayed recovery in children with AML

Targeted molecular therapy reduces initial development of NAFLD in mice

Virtual reality games fail to outplay card and ball games in stroke rehabilitation

Sheffield researchers identify novel function of C9orf72 protein linked to ALS and FTD

Itaconate can suppress pro-inflammatory activity of macrophages

Philips introduces DreamMapper app and website in the UK for people living with sleep apnoea

Researchers develop in vitro model system for investigating etiology of NAFLD

Group art therapy shows promise in treating Syrian refugee children with psychological problems

Everolimus combined with standard R-CHOP therapy shows promise in treating DLBCL patients

Scientists develop new nonradioactive method to determine telomere length

New AAV 3.0 program to create next-generation viral vectors for better treatment of inherited diseases

Researchers reveal novel mechanism by which viral protein VII suppresses immune alarm signals

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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