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'Simple' model predicts PegIFN response in chronic HBV

Chinese researchers have developed a scoring system based on hepatitis B virus-related clinical parameters to predict response to pegylated-interferon in chronic HBV patients.

23 Jun 2016

HCC predictors identified for chronic HBV patients with newly diagnosed cirrhosis

In patients with chronic hepatitis B virus infection who have been newly diagnosed with cirrhosis, the risk of hepatocellular carcinoma development can be ascertained using several clinical and molecular factors, study findings indicate.

23 Jun 2016

Maternal HBsAg can serve as HBV vertical transmission marker

Two studies have independently identified quantitative hepatitis B surface antigen as a marker to identify pregnant women with chronic hepatitis B virus infection whose infants are at high-risk of infection despite immunoprophylaxis.

23 Jun 2016

Novel combination therapy slows cancer growth in patients with advanced solid tumors

A phase 1 clinical trial testing a novel combination therapy developed by scientists at VCU Massey Cancer Center slowed the growth of cancer in the majority of trial participants, which were patients with advanced solid tumors.

22 Jun 2016

Study finds ARNI therapy could potentially prevent 28,484 deaths from heart failure each year

A UCLA-led study estimates that almost 28,500 deaths could be prevented each year in the U.S. through use of a new FDA-approved class of cardiovascular medication that helps reduce mortality in patients diagnosed with heart failure and reduced ejection fraction, the percentage of blood pumped from the heart with each contraction.

22 Jun 2016

Hops show promise in reducing breast cancer risk

Hops, the flower cones used in beer-making, are also found in dietary supplements designed to help treat post-menopausal symptoms and other conditions. Scientists are now investigating whether an extract from the plant could also help fend off breast cancer.

22 Jun 2016

Switch to rituximab shows anti-inflammatory effect in relapsing-remitting MS

Rituximab may be an attractive treatment option for patients with relapsing-remitting multiple sclerosis, suggest phase II study findings showing its efficacy in controlling inflammatory activity.

22 Jun 2016

Salvage inotuzumab ozogamicin improves ALL outcomes

Compared with standard chemotherapy, treatment with inotuzumab ozogamicin increases the rate of complete remission and allows a higher proportion of patients with relapsed or refractory acute lymphoblastic leukaemia to subsequently receive stem-cell transplantation, research suggests.

22 Jun 2016

Highly structured nutrition therapy provides substantial impact on A1C, body weight and lipid profiles

Researchers at Joslin Diabetes Center have announced the results of a study that may change how nutrition therapy is delivered to overweight and obese patients with type 2 diabetes.

22 Jun 2016

New CAR-based therapy using combined cancer target could be effective for solid tumors

Chimeric antigen receptors (CARs), engineered from a patient's own immune cells, have been successful for treating blood cancers, but using CARs for solid tumors has been limited by side effects to normal tissues containing the protein targeted by the engineered cells.

22 Jun 2016

High fibre diet can help reduce food allergies

Eating a diet rich in fibre can actually shape the immune system to reduce allergies to substances such as peanuts, new research shows.

21 Jun 2016

Plant-based therapies may show modest reductions in menopausal symptoms

An analysis of more than 60 studies suggests that some plant-based therapies are associated with modest reductions in the frequency of hot flashes and vaginal dryness but no significant reduction in night sweats, according to a study appearing in the June 21 issue of JAMA.

21 Jun 2016

Experts develop set of resolutions, conclusions to provide clarity on testosterone therapy

In an effort to address widespread concerns related to testosterone deficiency (TD) and its treatment with testosterone therapy, a group of international experts has developed a set of resolutions and conclusions to provide clarity for physicians and patients.

21 Jun 2016

Potential therapeutic approaches to combat chronic myeloid leukemia

Chronic myeloid leukemia (CML) develops through chromosomal alterations in blood-forming cells of the bone marrow and usually occurs in older persons. Around 20 percent of adults diagnosed with leukemia suffer from this type of blood cancer.

21 Jun 2016

Cytoreductive nephrectomy can extend survival of metastatic kidney cancer patients

Surgery to remove a cancerous kidney can often lengthen the lives of patients receiving targeted therapy for metastatic kidney cancer, but only about three in ten such patients undergo the procedure, according to a new study by researchers at Dana-Farber Cancer Institute and Brigham and Women's Hospital.

21 Jun 2016

Fixed-dose combination of sacubitril and valsartan for heart failure shows differing added benefit

The fixed-dose combination of sacubitril and valsartan (trade name: Entresto) has been approved since November 2015 for adults with symptomatic chronic heart failure with reduced pump function.

21 Jun 2016

Long-term opioid therapy may not be effective to manage pain in sickle cell disease patients

In a small study looking at pain assessments in adults with sickle cell disease, researchers at Johns Hopkins says overall, those treated long-term with opioids often fared worse in measures of pain, fatigue and curtailed daily activities than those not on long-term opioids.

21 Jun 2016

AF patients at risk for stroke mostly treated with aspirin-only prescription instead of blood thinners

Researchers at University of California San Diego School of Medicine and University of California, San Francisco School of Medicine report that more than 1 in 3 atrial fibrillation (AF) patients at intermediate to high risk for stroke are treated with aspirin alone, despite previous data showing this therapy to be inferior to blood thinners.

21 Jun 2016

New blood test could help predict severity of pulmonary arterial hypertension

Johns Hopkins Medicine researchers report that rising blood levels of a protein called hematoma derived growth factor (HDGF) are linked to the increasing severity of pulmonary arterial hypertension, a form of damaging high blood pressure in the lungs.

20 Jun 2016

Study finds link between pontosubicular necrosis and placental pathology

Pediatric and Developmental Pathology – A stillbirth occurs when a baby is born without any signs of life. Placental pathology is found to be related to the cause of death in a significant number of pregnancies that result in stillbirth

20 Jun 2016

Therapy News and Research

'Simple' model predicts PegIFN response in chronic HBV

HCC predictors identified for chronic HBV patients with newly diagnosed cirrhosis

Maternal HBsAg can serve as HBV vertical transmission marker

Novel combination therapy slows cancer growth in patients with advanced solid tumors

Study finds ARNI therapy could potentially prevent 28,484 deaths from heart failure each year

Hops show promise in reducing breast cancer risk

Switch to rituximab shows anti-inflammatory effect in relapsing-remitting MS

Salvage inotuzumab ozogamicin improves ALL outcomes

Highly structured nutrition therapy provides substantial impact on A1C, body weight and lipid profiles

New CAR-based therapy using combined cancer target could be effective for solid tumors

High fibre diet can help reduce food allergies

Plant-based therapies may show modest reductions in menopausal symptoms

Experts develop set of resolutions, conclusions to provide clarity on testosterone therapy

Potential therapeutic approaches to combat chronic myeloid leukemia

Cytoreductive nephrectomy can extend survival of metastatic kidney cancer patients

Fixed-dose combination of sacubitril and valsartan for heart failure shows differing added benefit

Long-term opioid therapy may not be effective to manage pain in sickle cell disease patients

AF patients at risk for stroke mostly treated with aspirin-only prescription instead of blood thinners

New blood test could help predict severity of pulmonary arterial hypertension

Study finds link between pontosubicular necrosis and placental pathology

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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