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Understanding how individuals respond to aspirin

Researchers have learned new information about how different people respond to aspirin, a globally prescribed drug in cardioprotection. The research team, led by scientists at Cardiff University in the United Kingdom and including representatives from the University of Alabama at Birmingham and the University of Colorado, identified more than 5,600 lipids — or fats — in blood platelets and gained new insights into how these cells respond to aspirin.

29 Apr 2016

Pioneering gene therapy may lead to potential cure for common causes of vision loss

Pioneering gene therapy has restored some vision to patients with a rare form of genetic blindness for as long as four years, raising hopes it could be used to cure common causes of vision loss, new University of Oxford research published today shows.

29 Apr 2016

Clinicians describe placement of first implantable hemodynamic monitor in single ventricle Fontan anatomy

While the Fontan procedure has improved the short- and mid-term outcomes for patients born with single ventricle anatomy, long-term complications of Fontan circulation include heart failure. These complications are thought to be secondary to elevated central venous pressure, chronic venous congestion and low cardiac output.

29 Apr 2016

Dopamine neuron transplants controlled by designer drug may fight Parkinson's disease in mice

A University of Wisconsin-Madison neuroscientist has inserted a genetic switch into nerve cells so a patient can alter their activity by taking designer drugs that would not affect any other cell. The cells in question are neurons and make the neurotransmitter dopamine, whose deficiency is the culprit in the widespread movement disorder Parkinson's disease.

29 Apr 2016

Nicotine metabolism linked with chronic alcohol abuse may contribute to poor smoking cessation rates

For smokers who are addicted to alcohol, chronic alcohol abuse may increase the rate of nicotine metabolism and contribute to poor smoking cessation rates. When smokers stop drinking the nicotine metabolism rates decline significantly, according to a study conducted by an international research team led by Roswell Park Cancer Institute. The research was a collaboration of scientists from Roswell Park, the University of California, San Francisco, and the Medical University of Silesia and Center of Addiction Treatment in Poland.

29 Apr 2016

Janssen gets positive CHMP opinion for IMBRUVICA (ibrutinib) to treat patients with previously untreated CLL

Janssen-Cilag International NV today announced that the Committee for Medicinal Products for Human Use of the European Medicines Agency has adopted a Positive Opinion, recommending broadening the existing marketing authorisation for ibrutinib as a single agent for the treatment of adult patients with previously untreated chronic lymphocytic leukaemia (CLL).

29 Apr 2016

Researchers report tumors can continue to grow even without supply of new blood vessels

When medication is used to shut off the oxygen supply to tumor cells, the cells adapt their metabolism in the medium term -- by switching over to producing energy without oxygen. This observation by biomedical scientists at the University of Basel and University Hospital Basel could be used for treatments that can inhibit tumor growth in the long term, as the researchers report in the latest issue of the journal Cell Reports.

29 Apr 2016

New class of cancer-driver gene may serve as unique therapeutic targets, biomarkers in TNBC

The discovery of long non-coding RNA (lncRNA) has dramatically changed the understanding of the biology of diseases such as cancer. The human genome contains about 20,000 protein-coding genes - less than 2 percent of the total - but 70 percent of the genome is made into non-gene-encoding RNA.

29 Apr 2016

Study examines benefits of exercise, behavioral therapy in MS patients

Groundhog Day 1994 is one Linda Friedrich will never forget. That's the day a neurologist told her, "You have multiple sclerosis and there's nothing we can do."

28 Apr 2016

Experimental therapy has over 90% remission rate for advanced leukemia patients

Twenty-seven of 29 patients with an advanced type of leukemia that had proved resistant to multiple other forms of therapy went into remission after their T cells (disease-fighting immune cells) were genetically engineered to fight their cancers.

28 Apr 2016

New form of SBRT to deliver radiation to specific area of prostate cancer

University Hospitals Seidman Cancer Center physicians have started the world's first clinical trial using a new form of stereotactic body radiotherapy (SBRT) to deliver radiation to a specific area of the prostate invaded with cancer - instead of the entire gland. The study aims to determine if treating a targeted cancer region within the prostate in early stage prostate cancer can increase treatment options and reduce the side effects of radiation.

28 Apr 2016

Bacterial invasion of lungs can lead to inflammation in COPD

Chronic obstructive pulmonary disease (COPD) is a common smoking-related lung illness and the third leading cause of death in the United States. Scientists have long believed that inhaling toxic gases and particles from tobacco smoke causes inflammation of the small airways in the lungs, leading to the development of COPD. However, the theory doesn't explain why airway inflammation and disease progression continue even after the patient stops smoking.

28 Apr 2016

More neurological resources needed to manage Zika virus infections

WFN Zika-Info-Service: World Federation of Neurology establishes Work Group on Zika virus to support international efforts - Lack of neurological resources in countries most concerned by the virus.

28 Apr 2016

MBCT could be effective treatment to prevent recurrence of depression

The largest meta-analysis so far of Mindfulness-Based Cognitive Therapy (MBCT) for recurrent depression has found that MBCT is an effective treatment option that can help prevent the recurrence of major depression. The study used anonymised individual patient data from nine randomized trials of MBCT. It suggests that for the millions of people who suffer recurrent depression it provides a treatment choice and an alternative or addition to other approaches such as maintenance anti-depressants.

28 Apr 2016

$Multidisciplinary experts assess effects of osteoporosis drugs on fracture healing$

Multidisciplinary experts assess effects of osteoporosis drugs on fracture healing

In people with osteoporosis, one fracture often leads to more fractures, and potentially a future of pain, disability, and poor quality of life. While studies have shown that such high-risk patients benefit from appropriate medication to reduce future fracture risk, more research is needed on the effect of osteoporosis medications on fracture healing.

28 Apr 2016

IPC PAS‘s chemical sensor can rapidly and effectively detect fungal infections

Fungal infections are a serious problem in modern health care. A critical factor in their successful treatment is time: the faster they are detected, the more effectively dangerous infections can be prevented.

28 Apr 2016

HBcrAg may predict HCC development

Research suggests a role for hepatitis B core-related antigen in the prediction of hepatocellular carcinoma development in nucleos(t)ide analogue treatment-naïve patients with chronic hepatitis B virus infection.

27 Apr 2016

Clinical study to evaluate safety of investigational cell therapy to treat chronic motor deficits after stroke

University Hospitals Case Medical Center is the first surgical site for a Phase 2b clinical trial study to further evaluate the safety and efficacy of an investigational cell therapy for the treatment of chronic motor deficit following an ischemic stroke.

27 Apr 2016

New study on retroviral DNA could help improve treatments for HIV infection

When retroviruses such as HIV infect a cell, they first make a copy of their RNA genome in the form of DNA. The relatively short viral DNA strand then moves to the cell nucleus, where it inserts itself into the host cell's DNA.

27 Apr 2016

Study reveals new function for CACNA1C gene in psychiatric diseases

A new study shows the death of newborn brain cells may be linked to a genetic risk factor for five major psychiatric diseases, and at the same time shows a compound currently being developed for use in humans may have therapeutic value for these diseases by preventing the cells from dying.

27 Apr 2016

Therapy News and Research

Understanding how individuals respond to aspirin

Pioneering gene therapy may lead to potential cure for common causes of vision loss

Clinicians describe placement of first implantable hemodynamic monitor in single ventricle Fontan anatomy

Dopamine neuron transplants controlled by designer drug may fight Parkinson's disease in mice

Nicotine metabolism linked with chronic alcohol abuse may contribute to poor smoking cessation rates

Janssen gets positive CHMP opinion for IMBRUVICA (ibrutinib) to treat patients with previously untreated CLL

Researchers report tumors can continue to grow even without supply of new blood vessels

New class of cancer-driver gene may serve as unique therapeutic targets, biomarkers in TNBC

Study examines benefits of exercise, behavioral therapy in MS patients

Experimental therapy has over 90% remission rate for advanced leukemia patients

New form of SBRT to deliver radiation to specific area of prostate cancer

Bacterial invasion of lungs can lead to inflammation in COPD

More neurological resources needed to manage Zika virus infections

MBCT could be effective treatment to prevent recurrence of depression

Multidisciplinary experts assess effects of osteoporosis drugs on fracture healing

IPC PAS‘s chemical sensor can rapidly and effectively detect fungal infections

HBcrAg may predict HCC development

Clinical study to evaluate safety of investigational cell therapy to treat chronic motor deficits after stroke

New study on retroviral DNA could help improve treatments for HIV infection

Study reveals new function for CACNA1C gene in psychiatric diseases

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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