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Metformin along with chemotherapy/radiation improves outcomes in head and neck cancer patients

Researchers at the University of Cincinnati College of Medicine have found that adding increasing doses of an approved Type 2 diabetes drug, metformin, to a chemotherapy and radiation treatment regimen in head and neck cancer patients is not well tolerated if escalated too quickly, but allowing slower escalation could be beneficial.

6 Jun 2016

Radiation therapy with bevacizumab/pembrolizumab improves outcomes in glioma patients

Patients with recurrent high-grade glioma brain tumors have few effective treatment options and the majority of available therapies do not improve survival. Moffitt Cancer Center will present preliminary results from a phase 1 study testing whether the addition of pembrolizumab to radiation therapy and bevacizumab is safe and can control tumor growth for these patients.

6 Jun 2016

Targeted therapy rucaparib shows promise in treating pancreatic cancer patients with BRCA mutation

The targeted therapy rucaparib, which has demonstrated robust clinical activity in ovarian cancer patients with a BRCA mutation, also showed promise in previously treated pancreatic cancer patients with the mutation, according to results from a phase II clinical study presented by Susan M. Domchek, MD, executive director of the Basser Center for BRCA at the Abramson Cancer Center of the University of Pennsylvania, at the American Society of Clinical Oncology Annual Meeting.

6 Jun 2016

Autoimmune diseases among lung cancer patients may make them unsuitable for immunotherapy

A significant proportion of lung cancer patients also have autoimmune disease, which may make them unsuitable for increasingly popular immunotherapy treatments, a team of researchers at UT Southwestern Medical Center's Harold C. Simmons Comprehensive Cancer Center has found.

6 Jun 2016

Novel treatment combination helps combat hard-to-treat pediatric neuroblastoma

For seven months, three-year-old Emil Abbasov underwent chemotherapy to fight the tangerine-sized, cancerous tumor growing in his abdomen. But each time, the tumor resisted harder. Each time, he felt more side effects.

6 Jun 2016

Combination therapy equally good at treating small cell lung cancer

HAVING radiotherapy once a day for six and a half weeks or twice a day for three weeks -- when combined with chemotherapy -- is equally good at treating small cell lung cancer that hasn't spread.

6 Jun 2016

Maintenance lenalidomide treatment improves overall survival in multiple myeloma patients

While several clinical trials have demonstrated that maintenance therapy with lenalidomide reduces the risk of disease progression in patients with multiple myeloma, there have been no definitive results regarding overall survival.

6 Jun 2016

Novel drug atezolizumab harnesses immune system to shrink tumors in advanced bladder cancer

A new drug that harnesses the immune system to attack tumors is highly effective against advanced bladder cancer, according to the results of an international clinical trial to be presented June 5 at the annual meeting of the American Society for Clinical Oncology.

6 Jun 2016

Experimental drug Rova-T shows safety, efficacy in treating advanced SCLC patients

The experimental "smart-bomb" drug rovalpituzumab tesirine (Rova-T) appears safe and shows efficacy in treating patients with advanced small cell lung cancer (SCLC), according to results from a first-in-human clinical trial to be presented today by a Memorial Sloan Kettering Cancer Center researcher at the 2016 American Society of Clinical Oncology Annual Meeting in Chicago.

6 Jun 2016

New research reveals advances that could change gynecologic cancer standard-of-care treatments

Advances that could change gynecologic cancer standard-of-care treatments are the centerpiece of key studies being presented by researchers from The University of Texas MD Anderson Cancer Center's Department of Gynecologic Oncology and Reproductive Medicine at the 2016 Annual Meeting of the American Society of Clinical Oncology.

6 Jun 2016

Nivolumab drug shows better response rate in metastatic bladder cancer patients

The immune checkpoint blockade drug nivolumab reduced tumor burden in 24.4 percent of patients with metastatic bladder cancer, regardless of whether their tumors had a biomarker related to the drug's target, according to clinical trial results from The University of Texas MD Anderson Cancer Center.

6 Jun 2016

Mastectomy followed by standard therapy improves survival in stage IV breast cancer patients

Surgery to remove the primary tumor in women diagnosed with stage IV breast cancer, followed by the standard combination of therapies, adds months to the patients' lives, compared with standard therapy alone, an international clinical trial led by a University of Pittsburgh Cancer Institute professor revealed.

4 Jun 2016

Researchers prove existence of olfactory receptor in pigment-producing skin cells

Researchers at Ruhr-Universität Bochum were the first ones to prove the existence of an olfactory receptor in pigment-producing cells in human skin, the so-called melanocytes. The team headed by Prof Dr Dr Dr habil. Hanns Hatt demonstrated that the violet-like scent Beta-Ionone can activate the receptor.

4 Jun 2016

Neutral atherosclerosis trial highlights effectiveness of optimal medical therapy

Salsalate has no greater effect than placebo on the progression of coronary artery plaque, show the findings of the randomised TINSAL-CVD trial.

3 Jun 2016

UZH scientists identify new class of protein compounds to treat HER2-positive breast cancer

In Switzerland alone, more than 5,700 women are diagnosed with breast cancer each year, and almost 1,400 of those affected die of the disease. In many very invasive forms of breast cancer, the cells have too much of the receptor HER2 on their surface.

3 Jun 2016

Lower quantities of CD74 protein in placentas of preeclamptic women can impact fetal development

Preeclampsia is one of the most common complications to occur during pregnancy, yet its causes are still unknown. A new study involving patients, cell cultures and animal experiments has now shown that those affected by the disease have lower quantities of the placenta's immune protein CD74, and that certain inflammatory factors are higher. These factors disrupt the formation of the placenta and leave the fetus undernourished.

3 Jun 2016

Clinical study finds two topical skin creams as effective noninvasive treatments for low-risk superficial BCC

Basal cell carcinoma is one of the most common cancers and its incidence is increasing worldwide, putting a significant burden on health services. Topical treatments are available for superficial basal cell carcinoma (BCC) but there has a lack of long-term follow-up data to guide treatment decisions.

3 Jun 2016

Mayo study finds mechanism by which Pten safeguards against tumor formation

Pten (short for phosphatase and tensin homolog) is a tumor suppressor that is defective in about 20-25 percent of all patients with cancers. Mayo Clinic researchers now have discovered that Pten safeguards against tumor formation by keeping chromosome numbers intact when a cell splits into two daughter cells.

3 Jun 2016

Scientists use new technique to repair fibrotic liver cells within the organ

Advances in stem cell research have made it possible to convert patients' skin cells into heart cells, kidney cells, liver cells and more in the lab dish, giving researchers hope that one day such cells could replace organ transplantation for patients with organ failure.

3 Jun 2016

Stimulating STING pathway to provoke life-extending immune response shows promise in AML

A protein known as STING plays a crucial role in the immune system's ability to "sense" cancer by recognizing and responding to DNA from tumor cells. Injection of compounds that activate the STING pathway directly into solid tumors in mice has been shown in prior studies to result in very potent anti-tumor immune responses.

3 Jun 2016

Therapy News and Research

Metformin along with chemotherapy/radiation improves outcomes in head and neck cancer patients

Radiation therapy with bevacizumab/pembrolizumab improves outcomes in glioma patients

Targeted therapy rucaparib shows promise in treating pancreatic cancer patients with BRCA mutation

Autoimmune diseases among lung cancer patients may make them unsuitable for immunotherapy

Novel treatment combination helps combat hard-to-treat pediatric neuroblastoma

Combination therapy equally good at treating small cell lung cancer

Maintenance lenalidomide treatment improves overall survival in multiple myeloma patients

Novel drug atezolizumab harnesses immune system to shrink tumors in advanced bladder cancer

Experimental drug Rova-T shows safety, efficacy in treating advanced SCLC patients

New research reveals advances that could change gynecologic cancer standard-of-care treatments

Nivolumab drug shows better response rate in metastatic bladder cancer patients

Mastectomy followed by standard therapy improves survival in stage IV breast cancer patients

Researchers prove existence of olfactory receptor in pigment-producing skin cells

Neutral atherosclerosis trial highlights effectiveness of optimal medical therapy

UZH scientists identify new class of protein compounds to treat HER2-positive breast cancer

Lower quantities of CD74 protein in placentas of preeclamptic women can impact fetal development

Clinical study finds two topical skin creams as effective noninvasive treatments for low-risk superficial BCC

Mayo study finds mechanism by which Pten safeguards against tumor formation

Scientists use new technique to repair fibrotic liver cells within the organ

Stimulating STING pathway to provoke life-extending immune response shows promise in AML

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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