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Immunotherapy with experimental monoclonal antibody could reduce neuroblastoma tumors

Neuroblastoma tumors shrank, some dramatically, in 80 percent of newly diagnosed, young, high-risk patients enrolled in a Phase II clinical trial that included an experimental monoclonal antibody. The immunotherapy agent was produced on the St. Jude Children's Research Hospital campus where the study is still underway.

3 Jun 2016

Analysing blood metabolites may help monitor effects of novel drugs

Testing for metabolic changes in the blood could indicate whether a cancer drug is working as designed, a new study reports.

3 Jun 2016

CNIO researchers avoid genetic manipulation to create lab mice with extra-long telomeres

The Telomeres and Telomerase Group at the Spanish National Cancer Research Centre, in collaboration with the Centre's Transgenic Mice Core Unit, has succeeded in creating mice in the laboratory with hyper-long telomeres and with reduced molecular ageing, avoiding the use of what to date has been the standard method: genetic manipulation.

3 Jun 2016

Retroviral replicating vector can extend lives of brain cancer patients

Doctors at UCLA, Cleveland Clinic, University of California San Diego School of Medicine and additional institutions have achieved a milestone in the development of a treatment for people with recurrent glioblastoma, the most common and aggressive form of brain cancer, by successfully demonstrating a modified virus that can extend the lives of patients with the disease.

2 Jun 2016

Some women with ovarian cancer do not receive beneficial surgical treatment, study finds

Nearly 20 percent of women with ovarian cancer do not undergo surgery, despite it being a standard part of treatment recommendations, according to new research from the Perelman School of Medicine at the University of Pennsylvania.

2 Jun 2016

Woman with higher BMI can face more challenges to being physically active

For women, barriers to physical activity can vary by weight, according to new study by Dartmouth researchers.

2 Jun 2016

Study uncovers racial, working class discrimination in private mental health care market

A new study suggests that psychotherapists discriminate against prospective patients who are black or working class.

2 Jun 2016

Advanced imaging kit Netspot gets FDA approval to detect rare neuroendocrine tumors

The U.S. Food and Drug Administration today approved Netspot, the first kit for the preparation of gallium Ga 68 dotatate injection, a radioactive diagnostic agent for positron emission tomography (PET) imaging.

2 Jun 2016

Nivolumab and ipilimumab combination could lead to effective treatment options for SCLC patients

Small cell lung cancer (SCLC) represents approximately 14 percent of all types of lung cancer. Many patients with SCLC respond to initial chemotherapy; however, they eventually relapse and develop progressive disease that has no effective treatment options.

2 Jun 2016

TxCell, LIED collaborate to develop CAR-Treg-based cellular immunotherapy for bullous pemphigoid

TxCell SA, a biotechnology company developing innovative, personalized cellular immunotherapies using regulatory T cells to treat severe chronic inflammatory and autoimmune diseases, today announces the signature of a strategic R&D collaboration agreement with the Lübeck Institute of Experimental Dermatology, a leading institution in the field of translational research on skin blistering diseases, part of the University of Lübeck in Germany.

2 Jun 2016

New NPS MedicineWise program aims to help health professionals improve diabetes management

A new educational program aims to help health professionals keep up to date with the latest evidence on second and third line medicines for lowering blood glucose.

2 Jun 2016

Scientists reveal how ER+ breast cancer uses cholesterol-based molecule to evade anti-hormone treatments

New research funded by Breast Cancer Now has identified how the most common breast cancers could be using a cholesterol-based molecule to evade standard anti-hormone treatments, causing patients’ disease to return.

2 Jun 2016

GET.ON online training course can effectively reduce depression risk

Inspired by promising tests of web-based health intervention measures, the researchers aimed to find out whether the risk of developing depression could be reduced by a six-week online training course called GET.ON. GET.ON is based on established therapy methods involving systematic problem solving and behavioural activation.

2 Jun 2016

Enzyme protein neutrophil elastase may be key contributor to development of muscular dystrophy

Scientists at the University of Liverpool have discovered that muscle cells affected by muscular dystrophy contain high levels of an enzyme that impairs muscle repair. This finding provides a new target for potential drug treatments for the disease, which currently has no cure.

2 Jun 2016

Nonprofits partner to raise awareness of scleroderma

If you've ever silently questioned someone wearing mittens on a warm spring day, the answer may be scleroderma. Or wondered why a woman, who otherwise appeared middle-aged, wore a face as wrinkle-free as her teenage daughter. The answer may be scleroderma.

2 Jun 2016

Excess phosphates in foods may lead to abnormally high blood pressure

Excess consumption of phosphate over-activates nerves that raise blood pressure, leading to abnormally high blood pressure, a new study in the American Journal of Physiology—Regulatory, Integrative and Comparative Physiology reports.

2 Jun 2016

Multiple cell and gene therapies can enhance cardiac function in mice modeled with MI

Researchers at the University of Utah compared the therapeutic potential of umbilical cord-derived sub-epithelial cells (UC-SECs), bone marrow-derived mesenchymal stem cells (BM-MSCs) and induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) -- all derived from human tissue -- along with genes (S100a1 and SDF-1a) and growth factor (VEGF165) to evaluate how injected biologics might enhance cardiac function in mice modeled with myocardial infarction (MI; commonly referred to as heart attack).

2 Jun 2016

$CD34+ cell therapy improves angina frequency in no option patients with class III/IV angina refractory$

CD34+ cell therapy improves angina frequency in no option patients with class III/IV angina refractory

A two-year, multi-center clinical study with 167 patients with class III-IV refractory angina randomized to low and high dose CD34+ cells or placebo has revealed that patients who received either a high or low dose of CD34 -- a member of a family of proteins that have an impact on vascular-associated tissue -- cells had a significant reduction in angina frequency over patients who received placebo.

2 Jun 2016

Interventions for breast cancer patients show benefits based on women’s stress levels

Is a couples' support group or an enhanced couples' group therapy intervention with skill instruction more effective for helping women diagnosed with early stage breast cancer? According to research from an investigator at Rutgers Cancer Institute of New Jersey and colleagues from other facilities across the country, neither intervention is more dominant, but each has its own benefits depending on the stress level of the patient.

2 Jun 2016

Just one stroke risk factor signals anticoagulation need in AF

The risk of stroke or systemic embolism is significantly increased in atrial fibrillation patients with just one risk factor apart from gender, say researchers.

2 Jun 2016

Therapy News and Research

Immunotherapy with experimental monoclonal antibody could reduce neuroblastoma tumors

Analysing blood metabolites may help monitor effects of novel drugs

CNIO researchers avoid genetic manipulation to create lab mice with extra-long telomeres

Retroviral replicating vector can extend lives of brain cancer patients

Some women with ovarian cancer do not receive beneficial surgical treatment, study finds

Woman with higher BMI can face more challenges to being physically active

Study uncovers racial, working class discrimination in private mental health care market

Advanced imaging kit Netspot gets FDA approval to detect rare neuroendocrine tumors

Nivolumab and ipilimumab combination could lead to effective treatment options for SCLC patients

TxCell, LIED collaborate to develop CAR-Treg-based cellular immunotherapy for bullous pemphigoid

New NPS MedicineWise program aims to help health professionals improve diabetes management

Scientists reveal how ER+ breast cancer uses cholesterol-based molecule to evade anti-hormone treatments

GET.ON online training course can effectively reduce depression risk

Enzyme protein neutrophil elastase may be key contributor to development of muscular dystrophy

Nonprofits partner to raise awareness of scleroderma

Excess phosphates in foods may lead to abnormally high blood pressure

Multiple cell and gene therapies can enhance cardiac function in mice modeled with MI

CD34+ cell therapy improves angina frequency in no option patients with class III/IV angina refractory

Interventions for breast cancer patients show benefits based on women’s stress levels

Just one stroke risk factor signals anticoagulation need in AF

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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