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Advanced genomic sequencing tracks deadly blood infection in cancer patients

The Translational Genomics Research Institute, working with international investigators, have discovered the source of a potential deadly blood infection in more than 50 South American cancer patients.

21 Mar 2016

N-KICS tool helps describe intensity of nursing care for children with CMC

Recent medical advances have resulted in increased survival of children with complex medical conditions (CMC), such as cerebral palsy, complex chromosomal anomalies, major congenital heart diseases and respiratory disease.

21 Mar 2016

St. Luke’s surgeon first in world to implant Medtronic’s new, MRI-compatible neurostimulator system

Steven Falowski, MD, Chief of Functional Neurosurgery at St. Luke’s University Health Network in Bethlehem, Pennsylvania today was the first surgeon in the world to implant Medtronic’s brand new, full-body, MRI-compatible paddle electrode leads for the Restore neurostimulator system.

21 Mar 2016

Ovarian serous cancer patients with overexpression of HER4 protein less likely respond to chemotherapy

Moffitt Cancer Center researchers discovered that patients with ovarian serous cancer and an overexpression of the HER4 protein are less likely to respond to chemotherapy and have a lower rate of survival.

21 Mar 2016

Cobimetinib with vemurafenib may have added benefit in melanoma with BRAF V600 mutation

Cobimetinib (trade name: Cotellic) has been approved since November 2015 in combination with vemurafenib for the treatment of adults with advanced, i.e. metastatic or unresectable, melanoma with a BRAF V600 mutation.

21 Mar 2016

Penn study calls on physicians to avoid over-prescribing opioids for surgical patients

Physicians are prescribing more opioid painkillers than ever before to patients undergoing common surgeries, according to new research from the department of Anesthesiology and Critical Care at the Perelman School of Medicine at the University of Pennsylvania.

21 Mar 2016

Simple TB screening and isoniazid can be effective for HIV patients at risk for TB

The number one killer of HIV patients in resource-limited areas, including parts of Africa and India, is tuberculosis (TB), underscoring the need for optimal treatments and effective strategies to address this deadly co-infection. But TB is harder to detect in HIV-infected patients and diagnostic test results take time, so many healthcare providers prescribe multi-drug TB treatments as a precaution.

20 Mar 2016

Manipulation of NAD could lead to potential therapy for acute kidney injury

Approximately one out of five hospitalized adults and one out of three hospitalized children worldwide experience acute kidney injury, the sudden loss of kidney function. Many different factors, including surgery, chemotherapy or shock, can lead to acute kidney injury, but exactly why the kidneys are so vulnerable to these and other stressors has not been well understood.

19 Mar 2016

Neutralizing acidic tumor environment increases efficacy of immune-targeting cancer therapies

Cancer cells have the ability to grow in an acidic tumor environment that is detrimental to other cells, including immune cells. In a Cancer Research cover article published this week, Moffitt Cancer Center reported that neutralizing the acidic tumor environment increases the efficacy of several immune-targeting cancer therapies.

19 Mar 2016

Value of PD-L1 testing in NSCLC debated

Two viewpoint articles published in JAMA Oncology provide opposing opinions on the benefit of testing for programmed death-ligand 1 expression in patients with non-small-cell lung cancer treated with checkpoint inhibitors.

18 Mar 2016

Stem cell therapy restores normal bone structure in mice with age-related osteoporosis

Imagine telling a patient suffering from age-related (type-II) osteoporosis that a single injection of stem cells could restore their normal bone structure. This week, with a publication in STEM CELLS Translational Medicine, a group of researchers from the University of Toronto and The Ottawa Hospital suggest that this scenario may not be too far away.

18 Mar 2016

Study: Conservative care could be a reasonable choice for selected kidney failure patients

A new study found no significant survival advantage among elderly kidney failure patients who chose dialysis over conservative management. The findings, which appear in an upcoming issue of the Clinical Journal of the American Society of Nephrology, indicate that conservative care may be a reasonable choice for selected older patients.

18 Mar 2016

Genomic profiling could help provide targeted therapies for difficult to treat cancer tumors

Research from Rutgers Cancer Institute of New Jersey examining difficult to treat cancer tumors through genomic profiling shows that tumors with alterations in a signaling pathway responsible for cell regulation may respond to targeted therapy regardless of where the tumor originated in the body.

18 Mar 2016

Clinical study finds no added benefit of using four TB drugs to save people with advanced HIV/AIDS

In a report on the so-called REMEMBER (Reducing Early Mortality and Early Morbidity by Empiric Tuberculosis Treatment) study -- a 10-nation, randomized clinical trial of adult outpatients -- investigators concluded that there was no added benefit of using four drugs for TB over just using one drug, isoniazid, to save lives in people with advanced HIV/AIDS.

18 Mar 2016

Neo-Bioscore staging system adds HER2 status for precise prognostic stratification of breast cancer subtypes

A new breast cancer staging system developed by researchers at The University of Texas MD Anderson Cancer Center finds that incorporating tumor biology is a critical prognostic indicator for women who undergo neoadjuvant, or pre-surgical, therapy for breast cancer.

18 Mar 2016

CIRM approves $6.3 million grant to support research on novel stem cell-based therapy for ALS

The Independent Citizens Oversight Committee of the California Institute for Regenerative Medicine approved yesterday a $6.3 million grant to a research team from the University of California, San Diego School of Medicine and University of California, Davis to pursue a novel human embryonic stem cell-based therapy to rescue and restore neurons devastated by amyotrophic lateral sclerosis or ALS.

18 Mar 2016

Therapy News and Research

Advanced genomic sequencing tracks deadly blood infection in cancer patients

N-KICS tool helps describe intensity of nursing care for children with CMC

St. Luke’s surgeon first in world to implant Medtronic’s new, MRI-compatible neurostimulator system

Ovarian serous cancer patients with overexpression of HER4 protein less likely respond to chemotherapy

Cobimetinib with vemurafenib may have added benefit in melanoma with BRAF V600 mutation

Penn study calls on physicians to avoid over-prescribing opioids for surgical patients

Simple TB screening and isoniazid can be effective for HIV patients at risk for TB

Manipulation of NAD could lead to potential therapy for acute kidney injury

Neutralizing acidic tumor environment increases efficacy of immune-targeting cancer therapies

Value of PD-L1 testing in NSCLC debated

Stem cell therapy restores normal bone structure in mice with age-related osteoporosis

Study: Conservative care could be a reasonable choice for selected kidney failure patients

Genomic profiling could help provide targeted therapies for difficult to treat cancer tumors

Clinical study finds no added benefit of using four TB drugs to save people with advanced HIV/AIDS

Neo-Bioscore staging system adds HER2 status for precise prognostic stratification of breast cancer subtypes

CIRM approves $6.3 million grant to support research on novel stem cell-based therapy for ALS

Breckenridge Pharmaceutical announces final FDA approval for Gabapentin Oral Solution

New 3D micro-scaffold technology promotes reprogramming of stem cells into neurons

Vascular events in CML may not be linked to TKI therapy

Real-life data show feasibility of imatinib discontinuation in CML

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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