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Global trials could save lives by changing treatment procedure for cancer in the future

Researchers from Edith Cowan University (ECU) are leading ground-breaking global trials which could save lives by changing how we treat cancer in the near future.

9 Jun 2023

Two studies spotlight intestinal T cells that could be targeted to prevent resistance to ICB cancer therapy

Two new studies in Science and Science Immunology spotlight a group of intestinal T cells with α4β7 integrin receptors that could be targeted to prevent resistance to immune checkpoint blockade (ICB) cancer immunotherapy.

8 Jun 2023

Cryo-EM reveals key atomic structures of the ends of actin filament

Actin filaments - protein structures critical to living movement from single cells to animals - have long been known to have polarity associated with their physical characteristics, with growing "barbed" and shrinking "pointed" ends.

8 Jun 2023

Insilico Medicine nominates pan-TEAD inhibitor as a potential solution for drug resistance in solid tumor patients

Insilico Medicine, a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM6331, a potential best-in-class pan-TEAD inhibitor, as a preclinical candidate compound (PCC) generated by Chemistry42, its proprietary generative chemistry-driven molecule design engine, targeting the Hippo pathway for the treatment of advanced solid tumors.

8 Jun 2023

Do COVID-19 drugs in aquatic matrices negatively impact microalgae and cyanobacteria communities?

Researchers evaluated the presence of coronavirus disease 2019 (COVID-19) drugs in river water.

8 Jun 2023

Single virus binds to a single receptor, study reveals

In Europe, the pandemic triggered in 2020 by the SARS-CoV-2 coronavirus is now largely under control. But why this virus is able to spread so efficiently remains unclear. A team of researchers led by Dr. Simone Backes, Dr. Gerti Beliu and Prof. Dr. Markus Sauer of the Julius Maximilians University of Würzburg (JMU) has now shown in a publication in "Angewandte Chemie" that some previous assumptions need to be reconsidered.

8 Jun 2023

New process can help to design drugs with fewer or no side effects

Have you ever wondered how drugs reach their targets and achieve their function within our bodies? If a drug molecule or a ligand is a message, an inbox is typically a receptor in the cell membrane.

7 Jun 2023

Study identifies a promising target for development of vaccine against spotted fever

A protein found in cells of the hard tick Amblyomma sculptum, the main vector of the bacterium that causes Brazilian spotted fever (also known as Rocky Mountain spotted fever), is essential to the tick's survival while feeding, making it a promising target for development of a vaccine, according to an article published in the journal Parasites & Vectors.

7 Jun 2023

UVA scientists discover a key determinant of multiple sclerosis risk

University of Virginia School of Medicine scientists have discovered a key determinant of our risk for multiple sclerosis (MS), advancing efforts to prevent and better treat the disease.

7 Jun 2023

Study reveals intricate pathway that dictates the cell’s ability to be resilient and plastic

Researchers have long thought that once a cell starts down its path of differentiation, growing into a skin cell or a liver cell or a neuron, that path could not be changed.

7 Jun 2023

New folate-targeting magnetic microrobot system shows great potential in cancer treatment

The limited ability of microrobots to assist drugs in entering cells hinders their therapeutic efficacy. To address this, the cancer-targeting molecule folic acid (FA) was introduced to microrobots to promote drug uptake by cancer cells via receptor-ligand-mediated endocytosis.

6 Jun 2023

World's fastest camera can detect fluorescence from single molecules

Researchers at Kyoto University, Okinawa Institute of Science and Technology Graduate University (OIST), and Photron Limited in Japan have developed the world's fastest camera capable of detecting fluorescence from single molecules.

6 Jun 2023

Drinking beetroot juice every day linked to reduced risk of repeat procedures and heart attacks in angina patients with stents

Drinking beetroot juice every day for six months after having a stent fitted reduced the chance of angina patients having a heart attack or needing a repeat procedure, according to new research presented at the British Cardiovascular Society conference.

6 Jun 2023

Therapeutic nanocarriers engineered from adult skin cells show promise for treating lung injury

Therapeutic nanocarriers engineered from adult skin cells can curb inflammation and tissue injury in damaged mouse lungs, new research shows, hinting at the promise of a treatment for lungs severely injured by infection or trauma.

6 Jun 2023

Efficient machine learning pipeline predicts the location of nanoscale interactions

Identifying whether and how a nanoparticle and protein will bind with one another is an important step toward being able to design antibiotics and antivirals on demand, and a computer model developed at the University of Michigan can do it.

6 Jun 2023

Microparticle-delivered therapy likely to be the first step toward stopping autoimmune diseases

According to the federal government's National Institute of Neurological Disorders and Stroke, nearly 3 million people worldwide - with almost a third in the United States - are living with multiple sclerosis (MS), a disabling neurological disease in which the body's immune system mistakenly attacks nerves feeding information to the central nervous system (the brain and spinal cord). Although rarely fatal, MS can lead to long-term disabilities, and impair movement, muscle control, vision and cognition.

6 Jun 2023

The universal role of Nsp1: Common mechanisms of translational shutdown by coronaviruses

Researchers investigate Nsp1 from SARS-CoV-2, MERS-CoV, and Bat-Hp-CoV using biophysical, structural, and biochemical assays.

5 Jun 2023

A SARS-CoV-2 spike-targeting bispecific T-cell engager strategy for controlling SARS-CoV-2 infection

Researchers described a novel strategy for controlling severe acute respiratory syndrome coronavirus 2.

5 Jun 2023

Innovative probe could deepen the understanding of key cellular messenger and lead to new drug discoveries

A ground-breaking study by Loughborough University and the University of Oxford has led to the development of a small molecule probe that could deepen our understanding of a crucial cellular messenger and lead to the development of new therapeutic drugs.

5 Jun 2023

Multiple sclerosis: Immune cell invasion enabled by blood-brain barrier breakdown

Blood-brain barrier breakdown in multiple sclerosis leads to immune cell infiltration into the central nervous system. Antigen presentation at the barrier promotes CD8+ T cell entry, triggering focal breakdown and hindering their invasion.

4 Jun 2023

Molecule News and Research

Global trials could save lives by changing treatment procedure for cancer in the future

Two studies spotlight intestinal T cells that could be targeted to prevent resistance to ICB cancer therapy

Cryo-EM reveals key atomic structures of the ends of actin filament

Insilico Medicine nominates pan-TEAD inhibitor as a potential solution for drug resistance in solid tumor patients

Do COVID-19 drugs in aquatic matrices negatively impact microalgae and cyanobacteria communities?

Single virus binds to a single receptor, study reveals

New process can help to design drugs with fewer or no side effects

Study identifies a promising target for development of vaccine against spotted fever

UVA scientists discover a key determinant of multiple sclerosis risk

Study reveals intricate pathway that dictates the cell’s ability to be resilient and plastic

New folate-targeting magnetic microrobot system shows great potential in cancer treatment

World's fastest camera can detect fluorescence from single molecules

Drinking beetroot juice every day linked to reduced risk of repeat procedures and heart attacks in angina patients with stents

Therapeutic nanocarriers engineered from adult skin cells show promise for treating lung injury

Efficient machine learning pipeline predicts the location of nanoscale interactions

Microparticle-delivered therapy likely to be the first step toward stopping autoimmune diseases

The universal role of Nsp1: Common mechanisms of translational shutdown by coronaviruses

A SARS-CoV-2 spike-targeting bispecific T-cell engager strategy for controlling SARS-CoV-2 infection

Innovative probe could deepen the understanding of key cellular messenger and lead to new drug discoveries

Multiple sclerosis: Immune cell invasion enabled by blood-brain barrier breakdown

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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