Proliferation News and Research

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Bacteria from seawater provide new leads to treat malignant melanoma

Malignant melanoma can be a particularly dangerous form of cancer, and more therapeutic options are needed. Now, researchers report in ACS Medicinal Chemistry Letters that a bacteria from seawater has inspired promising leads for an entirely new way to treat the disease.

7 Mar 2019

Anti-inflammatory drug shown to promote cardiac reprogramming

Once damaged, the human heart does a poor job of repairing itself, so this is a key priority for treating heart failure. One way of restoring cardiac function is to reprogram non-cardiac body cells such as fibroblasts into heart muscle cells (cardiomyocytes) using a collection of cardiac transcription factors.

6 Mar 2019

Novel cell rejuvenation approach may open new avenues for regenerative medicine

Scientists from the Luxembourg Centre for Systems Biomedicine of the University of Luxembourg and from the German Cancer Research Center have been able to rejuvenate stem cells in the brain of aging mice.

1 Mar 2019

Research identifies super-enhancers as novel target for pancreatic ductal adenocarcinoma

Differential H3K27AC marks were identified at enhancer regions of genes including c-MYC, MED1, OCT-4, NANOG, and SOX2 that can act as super-enhancers (SE), cluster of genes in non-cancerous, cancerous and metastatic PDAC cell lines.

1 Mar 2019

Study elucidates mechanism behind development of steroid diabetes

Steroids are used for treating various diseases such as allergic disorders, but they occasionally cause adverse effects, such as steroid diabetes and other metabolic disturbances. Since steroids act throughout the body, how these adverse effects are caused and by which organ are not well understood.

28 Feb 2019

New research finds how cancer cells acquire resistance to molecular-targeted drugs

Although molecular-targeted drugs have been known to show high efficacy to lung cancer patients, they also have limitations due to acquiring resistance to the drug used.

25 Feb 2019

Researchers discover origin of resistance to lung cancer

For treating cancer, drugs based on molecules known as tyrosine kinase inhibitors are sometimes used. One such tyrosine kinase inhibitor, called osimertinib, has been used to treat EGFR-mutated lung cancer with a certain degree of efficacy.

25 Feb 2019

Mechanism behind how diabetes causes muscle loss revealed

Diabetes mellitus is associated with various health problems including decline in skeletal muscle mass. A research group led by Professor Wataru Ogawa at the Kobe University Graduate School of Medicine revealed that elevation of blood sugar levels leads to muscle atrophy and that two proteins, WWP1 and KLF15, play key roles in this phenomenon.

23 Feb 2019

Study: Cancer stem-like cells are maintained by MTHFD2 mitochondrial metabolic enzyme

An increase in the incidence and mortality rate of cancer has been noted worldwide, especially for lung cancer.

22 Feb 2019

Harnessing the evolutionary games played by cancer cells to advance therapies

Despite rapid advances in targeted therapies for cancer, tumors commonly develop resistance to treatment. When resistance emerges, tumor cells continue to grow unchecked, despite all attempts to slow cancer progression.

19 Feb 2019

Customizing the Cellular Microenvironment to Improve Physiological Relevance

An interview with Marie-Charlotte Manus, discussing a new technology called PRIMO that improves the physiological relevance of cells in culture.

From Alveole 18 Feb 2019

Study discovers new therapy for aggressive blood cancer

Acute myeloid leukemia is the most common form of acute leukemia. It is characterized by an increase of malignant myeloid progenitor cells at the expense of mature blood cells.

13 Feb 2019

Over-abundance of energy to cells could increase cancer risk

It's well-known that obesity, diabetes and chronic inflammation are major risk factors for cancer. But just how cancer evolves in people with these diseases -- and why a healthy diet and exercising regularly can help prevent it -- is poorly understood.

12 Feb 2019

Proliferation News and Research

Bacteria from seawater provide new leads to treat malignant melanoma

Anti-inflammatory drug shown to promote cardiac reprogramming

Novel cell rejuvenation approach may open new avenues for regenerative medicine

Research identifies super-enhancers as novel target for pancreatic ductal adenocarcinoma

Study elucidates mechanism behind development of steroid diabetes

New research finds how cancer cells acquire resistance to molecular-targeted drugs

Researchers discover origin of resistance to lung cancer

Mechanism behind how diabetes causes muscle loss revealed

Study: Cancer stem-like cells are maintained by MTHFD2 mitochondrial metabolic enzyme

Harnessing the evolutionary games played by cancer cells to advance therapies

Customizing the Cellular Microenvironment to Improve Physiological Relevance

Study discovers new therapy for aggressive blood cancer

Over-abundance of energy to cells could increase cancer risk

New PET imaging agent may help measure efficacy or failure of hormone therapy for breast cancer

Inaccurate tests carried out on tuberculosis patients lead to high mortality rate

New discovery can explain resistance of cancer types to fatty acid metabolism inhibition

Cannabinoid receptor type 1 appears to be potential target to treat Down syndrome

Study of spermatogonial stem cells opens path for new strategies to treat male infertility

Protein CDK6 appears to be key factor in influencing development of MPN

Researchers describe first case of patient affected by dysfunctions in SLC28 gene family

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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