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CRISPR uncovers which gene fusions are critical for growth of cancer cells

In the first large-scale analysis of cancer gene fusions, which result from the merging of two previously separate genes, researchers at the Wellcome Sanger Institute, EMBL-EBI, Open Targets, GSK and their collaborators have used CRISPR to uncover which gene fusions are critical for the growth of cancer cells.

16 May 2019

Researchers elucidate the mechanism underlying dead-zone generation in circadian clocks

Most organisms on Earth have circadian clocks. In mammals, the circadian pacemaker is located in the suprachiasmatic nucleus of the brain.

14 May 2019

New portal ‘EU and My Food’ focuses on food safety measures in the EU

As the EFSA Focal Point in Germany, the German Federal Institute for Risk Assessment is also represented in the campaign with publications on the latest challenges, such as antimicrobial resistance and microplastics in food.

13 May 2019

New drug targeting genetic weakness could become first treatment for childhood brain cancer

A new type of drug that targets a genetic weakness in an untreatable childhood brain cancer could become the first ever treatment designed to target the disease.

9 May 2019

ComPARe project provides comprehensive estimate of preventable cancer burden in Canada

We know that there are many ways in which cancer can be prevented, but how many cancers can we prevent? And what do we have to do to really have an impact on reducing the burden of this disease? A special issue of Preventive Medicine, published by Elsevier, responds to these questions, showcasing results from the Canadian Population Attributable Risk of Cancer project—the most comprehensive, up-to-date estimate of the preventable burden of cancer in Canada.

8 May 2019

New book examines various phases of intervention research in hospice and palliative care

Behavioral Intervention Research in Hospice and Palliative Care: Building an Evidence Base sets forth research considerations and guidelines to build evidence-based interventions to improve end-of-life care.

3 May 2019

Scientists unravel mechanism of action of antitumor drug used to treat glioblastoma

Glioblastoma is an incurable type of brain tumor that is frequently associated with mutations in the epidermal growth factor receptor.

3 May 2019

BUSM receives $4.9 million MLSC grant to accelerate development of new brain imaging techniques

Boston University School of Medicine today announced that it had received a $4.9 million grant from the Massachusetts Life Sciences Center to create a state-of the-art facility to accelerate development of novel brain imaging techniques to track subtle changes in the brain after neurotrauma.

30 Apr 2019

New approach could simplify identification of transport proteins in mycobacteria

A team headed by Dr. Claudia Jessen-Trefzer of the University of Freiburg's Institute for Pharmaceuticals Sciences has for the first time identified a transport protein in mycobacteria which is responsible for the uptake of the nutrient L-arabinofuranose.

30 Apr 2019

Study highlights importance of continued efforts to enhance the reach of diabetes prevention programs

Using data from the 2016 National Health Interview Survey, Johns Hopkins researchers report that few American adults eligible for diabetes prevention programs are being referred to, or participating in, these programs.

26 Apr 2019

Combining biomaterial scaffolds with stem cells for tissue engineering applications

StemJournal, a new open access, peer-reviewed journal published by IOS Press, announces publication of its inaugural article, "Combining Stem Cells and Biomaterial Scaffolds for Constructing Tissues and Cell Delivery," by Stephanie M. Willerth, PhD, and Shelly E. Sakiyama-Elbert, PhD.

25 Apr 2019

Researchers uncover potential clue to halt destruction of nerve cells in people with ALS

A special focus on rogue proteins may hold future promise in stopping the progression of nerve cell destruction in people who have amyotrophic lateral sclerosis or frontotemporal dementia.

24 Apr 2019

New range prediction approach increases accuracy, safety and tolerability of proton therapy

Today (Tuesday, 23 April) marks the beginning of a new era in treatment planning at the University Proton Therapy Dresden of the University Hospital in Dresden (Germany): For the worldwide first time, a new approach increases the accuracy, safety and probably also the tolerability of proton therapy.

24 Apr 2019

Novel system enables researchers to study bacteria within mini-tissues in a dish

Engineering bacteria to intelligently sense and respond to disease states, from infections to cancer, has become a promising focus of synthetic biology.

19 Apr 2019

Diabetic drug shows potential to be repurposed as heart disease treatment for non-diabetic patients

The commonly used diabetes drug metformin could reverse the harmful thickening of heart muscle that leads to cardiovascular disease, according to a study at the University of Dundee.

17 Apr 2019

More openness, transparency in assessment of active substances in plant protection products

No third party may fundamentally publish the work of another without their consent. The BfR is therefore exercising its rights as a scientific institute.

15 Apr 2019

FDA offers funding to create the most advanced living mimicry of a human lung

The University of Colorado Anschutz Medical Campus announced the funding of $3.4 million by the U.S. Food and Drug Administration to create the most advanced living mimicry of a human lung to identify toxicity and cancer-causing potential of emerging tobacco products.

12 Apr 2019

New strategy for editing and repairing genetic mutation associated with microduplications

Scientists at UMass Medical School have developed a strategy for editing and repairing a particular type of genetic mutation associated with microduplications using CRISPR/Cas9 and a seldom-used DNA repair pathway.

11 Apr 2019

Scientists develop technique to clear abnormal tau protein from human neurons

Harnessing a probe used to image the brain in diagnosing Alzheimer's disease and related forms of dementia, scientists at Dana-Farber Cancer Institute and Massachusetts General Hospital have successfully cleared patient-derived brain cells of an abnormal protein associated with dementia and other neurogenerative disorders.

10 Apr 2019

Synthetic antibody rapidly prevents Zika infection in mice and non-human primates

A DNA-encoded monoclonal antibody prevents Zika infection in mice and non-human primates, researchers report April 5 in the journal Molecular Therapy.

8 Apr 2019