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Drug-incorporated nanoparticle platforms allow for selective targeting of cancer cells

Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells. It is a leading cause of death and the burden is expected to grow worldwide due to the growth and aging of the population, mainly in less developed countries, in which about 82% of the world's population resides. By 2030, the global burden is expected to grow to 21.7 million new cancer cases and 13 million cancer deaths simply due to the growth and aging of the population. Current cancer therapy approaches are based in surgery, radiotherapy and chemotherapy, being the chemotherapy the one that shows the greater efficiency for cancer treatment, mainly in more advanced stages. A major problem with this conventional chemotherapy is its toxicity and it also destroys healthy tissues resulting in systemic toxicity besides beneficial characteristics of killing cancer cells. Anticancer drugs also destroy healthy tissues resulting in systemic toxicity.

8 Mar 2016

Boosting the body's natural defences to stop RSV infection

Babies at risk of a serious lung infection could be helped by a therapy based on the body's natural immune defences.

8 Mar 2016

Researchers discover how E. coli bacteria adhere to urinary tract

Almost every second woman suffers from a bladder infection at some point in her life. Also men are affected by cystitis, though less frequently. In eighty percent of the cases, it is caused by the intestinal bacterium E. coli.

8 Mar 2016

Patients with moderate-to-severe plaque psoriasis achieve significant improvement with ixekizumab

Eli Lilly and Company announced today that patients with moderate-to-severe plaque psoriasis who did not respond to treatment with etanercept achieved significant improvement in their psoriasis plaques when treated with ixekizumab in a Phase 3 clinical trial. Detailed results of the UNCOVER-2 study were presented during the American Academy of Dermatology Annual Meeting taking place March 4-8 in Washington, D.C.

8 Mar 2016

ACGT awards new research grants to take researchers to next level in cancer treatment

Alliance for Cancer Gene Therapy, the nation's only nonprofit dedicated exclusively to cell and gene therapies for cancer, is delighted to announce the recipients of its 2016 ACGT Young Investigator Grants.

8 Mar 2016

New study finds dramatic increase in young athletes undergoing Tommy John surgery

A new study found a dramatic increase in the number of adolescents undergoing "Tommy John" surgery to repair a pitching-related elbow injury in recent years, outstripping growth among major league pitchers.

8 Mar 2016

Xencor begins XmAb5871 Phase 2 trials in patients with IgG4-RD and Systemic Lupus Erythematosus

Xencor, Inc., a clinical-stage biopharmaceutical company developing engineered monoclonal antibodies for the treatment of autoimmune diseases, asthma and allergic diseases and cancer, today announced dosing the first patient in a Phase 2 trial of XmAb5871 in patients with IgG4-Related Disease (IgG4-RD).

8 Mar 2016

Specialized tests can help dermatologists provide individualized care for melanoma patients

Melanoma rates in the United States have doubled over the past two decades.1 Fortunately for patients, this increase in melanoma incidence has been accompanied by the development of more effective tools for diagnosis and treatment, including genetic and molecular testing.

7 Mar 2016

Preseason prevention programs beneficial to young baseball players

Preseason prevention programs are beneficial to young baseball pitchers, according to research presented today at the American Orthopaedic Society for Sports Medicine's Specialty Day.

7 Mar 2016

Systemic sclerosis: an interview with Dr Kristin Highland

Systemic sclerosis, also known as scleroderma, is a rare disease characterized by the thickening and scarring of connective tissue of multiple organs in the body

7 Mar 2016

New FDA approval expands use of AstraZeneca's Faslodex for women with HR+, HER2- metastatic breast cancer

AstraZeneca today announced that the US Food and Drug Administration has approved a new indication in the US, expanding the use of Faslodex (fulvestrant) to include use in combination with Ibrance (palbociclib).

7 Mar 2016

CTRC study provides new insight into how Angelina Jolie gene functions in normal breast tissue

Scientists from the Cancer Therapy & Research Center in San Antonio today (March 4) published work that provides deeper insight into how the Angelina Jolie gene, BRCA1, functions in normal breast tissue and how its loss results in breast cancer.

7 Mar 2016

Study shows link between obesity and treatment outcomes in breast cancer patients

A study published in the international journal, Cancer Biology and Therapy, describes research into the correlation between generalized obesity and treatment outcomes in breast cancer patients younger than 45 years old.

7 Mar 2016

Complex biomarker tests for molecularly targeted therapies lack evidentiary standards

Potentially useful biomarker tests for molecularly targeted therapies are not being adopted appropriately into clinical practice because of a lack of common evidentiary standards necessary for regulatory, reimbursement, and treatment decisions.

7 Mar 2016

Inherited gene after black plague may help treat HIV patients co-infected with hepatitis C

The Black Death swept Europe in the 14th century eliminating up to half of the population but it left genetic clues that now may aid a University of Cincinnati researcher in treating HIV patients co-infected with hepatitis C using an anti-retroviral drug therapy.

7 Mar 2016

Johns Hopkins Greenberg Bladder Cancer Institute awards grants for 10 bladder cancer research projects

A study of obesity and related metabolic changes on bladder cancer incidence and deaths, and a plan to use stem cells to grow novel urinary tubes are among 10 research projects awarded funding by the Johns Hopkins Greenberg Bladder Cancer Institute.

7 Mar 2016

Omalizumab treatment significantly decreases colds in inner-city children with allergic asthma

Treatment with omalizumab significantly decreases the number of colds in inner-city children with allergic asthma, researchers reported at a press conference today at the American Academy of Allergy, Asthma and Immunology 2016 Annual Meeting in Los Angeles. Omalizumab, sold under the brand name Xolair, is an injectable antibody that can be used to treat asthma cases not controlled by inhaled corticosteroids.

7 Mar 2016

Expression of BIRC3 protein associated with poor survival, recurrent disease in GBM patients

Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with low survival rates, with newly diagnosed patients surviving a median of 14 months and recurrent patients surviving a median of only 3 to 9 months. New therapeutic targets and biomarkers for prognosis are urgently needed.

7 Mar 2016

RUVICA (ibrutinib) capsules approved for treatment-naïve CLL patients

The U.S. Food and Drug Administration has approved IMBRUVICA (ibrutinib) capsules for treatment-naïve patients with chronic lymphocytic leukemia (CLL).

4 Mar 2016

IOM report elucidates state of ovarian cancer incidence, treatment and research

Ovarian cancer, one of the deadliest malignancies, is actually a constellation of different cancers that may originate in other organs and should not be treated as a single disease, concludes a new congressionally mandated report on the state of ovarian cancer incidence, treatment and research. The report, published by the Institute of Medicine of the National Academies of Sciences, Engineering, and Medicine, also highlights persistent serious disparities in delivery of care across different groups of women in the U.S., and suggests promising areas for further research.

4 Mar 2016

Therapy News and Research

Drug-incorporated nanoparticle platforms allow for selective targeting of cancer cells

Boosting the body's natural defences to stop RSV infection

Researchers discover how E. coli bacteria adhere to urinary tract

Patients with moderate-to-severe plaque psoriasis achieve significant improvement with ixekizumab

ACGT awards new research grants to take researchers to next level in cancer treatment

New study finds dramatic increase in young athletes undergoing Tommy John surgery

Xencor begins XmAb5871 Phase 2 trials in patients with IgG4-RD and Systemic Lupus Erythematosus

Specialized tests can help dermatologists provide individualized care for melanoma patients

Preseason prevention programs beneficial to young baseball players

Systemic sclerosis: an interview with Dr Kristin Highland

New FDA approval expands use of AstraZeneca's Faslodex for women with HR+, HER2- metastatic breast cancer

CTRC study provides new insight into how Angelina Jolie gene functions in normal breast tissue

Study shows link between obesity and treatment outcomes in breast cancer patients

Complex biomarker tests for molecularly targeted therapies lack evidentiary standards

Inherited gene after black plague may help treat HIV patients co-infected with hepatitis C

Johns Hopkins Greenberg Bladder Cancer Institute awards grants for 10 bladder cancer research projects

Omalizumab treatment significantly decreases colds in inner-city children with allergic asthma

Expression of BIRC3 protein associated with poor survival, recurrent disease in GBM patients

RUVICA (ibrutinib) capsules approved for treatment-naïve CLL patients

IOM report elucidates state of ovarian cancer incidence, treatment and research

Industry Focus eBook - Cell biology (5th edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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