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Researchers identify definitive genetic defect in angiocentric gliomas

Diagnosis and treatment decisions for a recently recognized type of children's brain tumor should be improved by the discovery of the genetic mechanism that causes it, say researchers who identified the unusual DNA abnormality in angiocentric gliomas.

2 Feb 2016

Radiation could increase responses to innovative immune-based therapeutic approaches to fight cancer

A team of Georgia State University researchers is fighting cancers using a combination of therapies and recently found ways that radiation could maximize responses to novel immune-based therapeutic approaches to fight cancer.

1 Feb 2016

New study lays foundation for future gene replacement therapies to treat ALS patients

Scientists have demonstrated for the first time that it is possible to specifically modify gene expression in diseased upper motor neurons, brain cells that break down in ALS.

1 Feb 2016

Rochester scientists identify stem cells capable of skull formation, craniofacial bone repair in mice

A team of Rochester scientists has, for the first time, identified and isolated a stem cell population capable of skull formation and craniofacial bone repair in mice--achieving an important step toward using stem cells for bone reconstruction of the face and head in the future, according to a new paper in Nature Communications.

1 Feb 2016

Alternative splicing: a new approach to drug development? An interview with Lucy Donaldson

RNA is becoming an interesting drug target as it takes possible intervention back one step to the synthesis of a target protein, instead of trying to block or inhibit a process.

1 Feb 2016

Experts call for new approach to asthma and COPD patient management

Defining a patient's symptoms using the historical diagnostic labels of asthma and chronic obstructive pulmonary disease (COPD) is an outdated approach to understanding an individual's condition, according to experts writing in the European Respiratory Journal today (Feb. 1, 2016).

1 Feb 2016

Proton beam therapy safe for treating childhood brain cancer medulloblastoma

Proton beam therapy--a more precise form of radiotherapy--to treat the childhood brain cancer medulloblastoma appears to be as safe as conventional radiotherapy with similar survival rates, according to new research published in The Lancet Oncology journal today.

1 Feb 2016

SLU clinical psychologist helps patients battle fears, phobias

Some fear is rational, keeping us appropriately cautious in the face of dangerous animals, hot stoves and contagions that could make us ill. But rational caution can turn to irrational panic about imagined terrors that are unlikely to occur or cause much actual damage if they did.

31 Jan 2016

HIV protein alters activity of networked neurons

Nearly half of HIV infected patients suffer from impaired neurocognitive function. The HIV protein transactivator of transcription (Tat) is an important contributor to HIV neuropathogenesis because it is a potent neurotoxin that continues to be produced despite treatment with antiretroviral therapy.

31 Jan 2016

Lipofilling safe for breast reconstruction

For women undergoing breast cancer surgery, a technique called lipofilling—using the patient's own fat cells to optimize the results of breast reconstruction—does not increase the risk of recurrent breast cancer, reports a study in the February issue of Plastic and Reconstructive Surgery, the official medical journal of the American Society of Plastic Surgeons.

31 Jan 2016

Applying ultrasound therapies for recovery of cardiac stem cells

A joint project of researchers from Universidad Politécnica de Madrid (UPM), Julius Wolff Institute and led by Spanish National Center for Cardiovascular Research shows that when cardiac stem cells undergo low-intensity pulsed ultrasound treatment, these cells can perform continuing modifications, tissue remodeling and regeneration of damaged cardiac tissue after a heart attack.

31 Jan 2016

Mild reduction in food intake slows development of autosomal-dominant polycystic kidney disease

A small reduction in food intake—less than required to cause weight loss—dramatically slowed the development of a common genetic disorder called autosomal-dominant polycystic kidney disease (ADPKD) in mice, a new study in American Journal of Physiology—Renal Physiology reports.

30 Jan 2016

FDA-approved blood pressure drug reduces cell damage linked to Alzheimer's disease

In laboratory neuronal cultures, an FDA-approved drug used to treat high blood pressure reduced cell damage often linked to Alzheimer's disease, say researchers at Georgetown University Medical Center and the National Institutes of Health.

30 Jan 2016

Proton radiotherapy as effective as standard photon therapy in treating pediatric brain tumor

The use of proton radiotherapy to treat the most common malignant brain tumor in children is as effective as standard photon (x-ray) radiation therapy while causing fewer long-term side effects such as hearing loss and cognitive disorders, according to a study receiving online publication in Lancet Oncology.

30 Jan 2016

EC approves expanded use of Daklinza (daclatasvir) for patients with chronic HCV and HIV co-infection

Bristol-Myers Squibb today announced that the European Commission has approved the expanded use of Daklinza, a first-in-class oral, once-a-day pill used in combination with other treatments as an option for adult patients with chronic hepatitis C virus infection who are co-infected with HIV or who have had a prior liver transplant.

30 Jan 2016

Sirolimus chemoprevention supported in organ transplant recipients

In solid-organ transplant recipients diagnosed with cancer post-transplant, treatment with sirolimus reduces the risk of developing a subsequent skin cancer, US investigators report in JAMA Dermatology.

29 Jan 2016

Multinational study suggests new way to classify gliomas

A comprehensive analysis of the molecular characteristics of gliomas—the most common malignant brain tumor—explains why some patients diagnosed with slow-growing (low-grade) tumors quickly succumb to the disease while others with more aggressive (high-grade) tumors survive for many years.

29 Jan 2016

Allergan's investigational medication rapastinel granted FDA Breakthrough Therapy designation

Allergan plc., a leading global pharmaceutical company today announced that its Phase III ready investigational medication rapastinel (GLYX-13) received Breakthrough Therapy designation from the U.S. Food and Drug Administration for adjunctive treatment of Major Depressive Disorder (MDD).

29 Jan 2016

Eisai's Halaven receives FDA approval for treatment of patients with metastatic liposarcoma

Eisai Inc. announced today that the U.S. Food and Drug Administration approved Halaven (eribulin mesylate) Injection (0.5 mg per mL) for the treatment of patients with unresectable or metastatic liposarcoma who have received a prior anthracycline-containing regimen.

29 Jan 2016

Access for new melanoma treatment remains uncertain for patients despite UK launch

Novartis announced today that Tafinlar (dabrafenib) + Mekinist (trametinib), the first oral combination therapy to be licensed for advanced melanoma, is now available in the UK for the treatment of adult patients with unresectable or metastatic melanoma with a BRAF V600 mutation.

29 Jan 2016

Therapy News and Research

Researchers identify definitive genetic defect in angiocentric gliomas

Radiation could increase responses to innovative immune-based therapeutic approaches to fight cancer

New study lays foundation for future gene replacement therapies to treat ALS patients

Rochester scientists identify stem cells capable of skull formation, craniofacial bone repair in mice

Alternative splicing: a new approach to drug development? An interview with Lucy Donaldson

Experts call for new approach to asthma and COPD patient management

Proton beam therapy safe for treating childhood brain cancer medulloblastoma

SLU clinical psychologist helps patients battle fears, phobias

HIV protein alters activity of networked neurons

Lipofilling safe for breast reconstruction

Applying ultrasound therapies for recovery of cardiac stem cells

Mild reduction in food intake slows development of autosomal-dominant polycystic kidney disease

FDA-approved blood pressure drug reduces cell damage linked to Alzheimer's disease

Proton radiotherapy as effective as standard photon therapy in treating pediatric brain tumor

EC approves expanded use of Daklinza (daclatasvir) for patients with chronic HCV and HIV co-infection

Sirolimus chemoprevention supported in organ transplant recipients

Multinational study suggests new way to classify gliomas

Allergan's investigational medication rapastinel granted FDA Breakthrough Therapy designation

Eisai's Halaven receives FDA approval for treatment of patients with metastatic liposarcoma

Access for new melanoma treatment remains uncertain for patients despite UK launch

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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