Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

Early menopause puts women at greater risk of dementia later in life

Women who enter menopause very early, before age 40, were found to be more likely to develop dementia of any type later in life compared to women who begin menopause at the average menopause-onset age of 50 to 51 years, according to preliminary research to be presented at the American Heart Association's Epidemiology, Prevention, Lifestyle & Cardiometabolic Health Conference 2022.

1 Mar 2022

Research sheds light on the role of lipids in Alzheimer’s disease development

Neurons in the brain coexist with and rely on many other cell types to function properly. Astrocytes, which take their name from their star shape, ensure the survival of neurons by feeding and detoxifying them with the help of a multifunctional protein, APOE.

1 Mar 2022

Mechanisms leading to Parkinson's disease following SARS-CoV-2 infection

In a recent study posted to the bioRxiv* preprint server, researchers demonstrated the impact of an amyloidogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protein fragment named SFYVYSRVK (SK9) on the α-synuclein (aS) monomers and fibrils, a potential risk factor for Parkinson's disease.

28 Feb 2022

Novel molecular pathway shared by two neurodegenerative disorders discovered

Scientists from two independent research teams have discovered how the mislocalization of a protein, known as TDP-43, alters the genetic instructions for UNC13A, providing a possible therapeutic target that could also have implications in treating amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other forms of dementia.

28 Feb 2022

People with better physical fitness are less likely to develop Alzheimer's disease

People who are more physically fit are less likely to develop Alzheimer's disease than people who are less physically fit, according to a preliminary study released today, February 27, 2022, that will be presented at the American Academy of Neurology's 74th Annual Meeting being held in person in Seattle, April 2 to 7, 2022 and virtually, April 24 to 26, 2022.

28 Feb 2022

Researchers untangle the mysteries around type-2 diabetes

For more than 30 years, scientists have been trying to unravel the mystery of how a key biological molecule self assembles into a rogue protein-like substance known as amyloid, which is thought to play a role in the development of type-2 diabetes - a disease that affects 300 million people worldwide.

25 Feb 2022

Study describes how brain pulsation changes during sleep

The University of Oulu Functional Neuroimaging research group has for the first time succeeded in describing how the various types of pulsations in the human brain change when a person sleeps.

24 Feb 2022

Large study funded by $33.1 million grant focuses on risk and resilience in the aging brain

A large study that investigates just what keeps our brains sharp as we age and what contributes to cognitive decline has been launched by researchers from Washington University School of Medicine in St. Louis, Harvard University/Massachusetts General Hospital, the University of Minnesota Medical School and the University of California Los Angeles.

23 Feb 2022

Study links lower acculturation levels with worse cognitive function in older Hispanics

A new study on culture and cognition found that long-term Hispanic immigrants who were less acculturated to the U.S. performed significantly worse on cognitive function tests than their highly acculturated peers.

22 Feb 2022

A blood test proves to be highly accurate in detecting early signs of Alzheimer's disease

A blood test developed at Washington University School of Medicine in St. Louis has proven highly accurate in detecting early signs of Alzheimer's disease in a study involving nearly 500 patients from across three continents, providing further evidence that the test should be considered for routine screening and diagnosis.

22 Feb 2022

Spectrum of autoantibodies linked to autoimmune diseases in patients with different COVID-19 clinical outcomes

A broad evaluation of autoimmune disease-associated autoantibodies that have been observed in COVID-19 patients was performed.

22 Feb 2022

Advanced imaging reveals the loss of brain synapses in patients with mild symptoms of Alzheimer's

Advanced imaging technology developed by Yale researchers has helped them confirm that the destruction of brain synapses underlies the cognitive deficits experienced by patients with Alzheimer's disease, according to a study published Feb. 17 in the journal Alzheimer's & Dementia: The Journal of the Alzheimer's Association.

17 Feb 2022

New insights into why women develop Alzheimer's symptoms earlier and exhibit faster memory decline

A joint study by Nanyang Technological University, Singapore and National University of Singapore (NUS) scientists has examined why, in mice, female brains are more predisposed to Alzheimer's disease and other neurodegenerative diseases.

16 Feb 2022

New cell model for Alzheimer's disease could be useful in early diagnosis and testing of new therapies

Researchers at the University of Eastern Finland have developed and characterized a new cell model for Alzheimer's disease that has wide utility for research and could prove useful in early diagnosis and testing of new therapies.

16 Feb 2022

Inside the tactical tug of war over the controversial Alzheimer’s drug

The drug industry, patient advocates, and congressional Republicans have all attacked federal officials' decision to decline routine Medicare coverage for a controversial Alzheimer's drug.

16 Feb 2022

Regulating inflammation in Alzheimer's disease using a nanocleaner

In this new article publication from Acta Pharmaceutica Sinica B, authors Ting Lei, Zhihang Yang, Xue Xia, Yuxiu Chen, Xiaotong Yang, Rou Xie, Fan Tong, Xiaolin Wang, Huile Gao from Sichuan University, Chengdu, China and Macau University of Science and Technology, Macau, China discuss how nanocleaners can specifically penetrate the blood‒brain barrier at lesions to clean toxic proteins and regulate inflammation in Alzheimer's disease.

14 Feb 2022

UCI biologists discover how a protective mutation may reduce Alzheimer's risk

While the word "mutation" may conjure up alarming notions, a mutation in brain immune cells serves a positive role in protecting people against Alzheimer's disease.

14 Feb 2022

Hyperactive microglia can have a protective effect in the course of neurodegenerative diseases

Findings by researchers from Germany support the view that hyperactive immune cells in the brain can have a protective effect in the course of neurodegenerative diseases.

14 Feb 2022

Progression of Alzheimer's disease is linked to oxidative brain damage, research confirms

Increased oxidative damage is linked to neurodegenerative disorders such as Alzheimer's disease (AD). Even though the pathophysiology of AD has been widely investigated, the likely relationship between mitochondrial dysfunction and the disease remains largely unknown.

14 Feb 2022

New insights into perspectives of older adults and caregivers on healthcare navigation, decision making

As part of an initiative funded by The John A. Hartford Foundation, FAIR Health conducted a nationwide study comprising two surveys geared toward older patients (adults 65 and older) and family caregivers/care partners.

12 Feb 2022

Alzheimer's Disease News and Research

Further Reading

Early menopause puts women at greater risk of dementia later in life

Research sheds light on the role of lipids in Alzheimer’s disease development

Mechanisms leading to Parkinson's disease following SARS-CoV-2 infection

Novel molecular pathway shared by two neurodegenerative disorders discovered

People with better physical fitness are less likely to develop Alzheimer's disease

Researchers untangle the mysteries around type-2 diabetes

Study describes how brain pulsation changes during sleep

Large study funded by $33.1 million grant focuses on risk and resilience in the aging brain

Study links lower acculturation levels with worse cognitive function in older Hispanics

A blood test proves to be highly accurate in detecting early signs of Alzheimer's disease

Spectrum of autoantibodies linked to autoimmune diseases in patients with different COVID-19 clinical outcomes

Advanced imaging reveals the loss of brain synapses in patients with mild symptoms of Alzheimer's

New insights into why women develop Alzheimer's symptoms earlier and exhibit faster memory decline

New cell model for Alzheimer's disease could be useful in early diagnosis and testing of new therapies

Inside the tactical tug of war over the controversial Alzheimer’s drug

Regulating inflammation in Alzheimer's disease using a nanocleaner

UCI biologists discover how a protective mutation may reduce Alzheimer's risk

Hyperactive microglia can have a protective effect in the course of neurodegenerative diseases

Progression of Alzheimer's disease is linked to oxidative brain damage, research confirms

New insights into perspectives of older adults and caregivers on healthcare navigation, decision making

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