Mutation News and Research

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Analyzing the evolution of SARS-CoV-2 RNA polymerase in humans

In a new study, researchers examined the impact of mutations on the structural thermodynamic stability (structural stability) of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) through free energy computation.

11 Jan 2022

A study on COVID vaccinated vs. unvaccinated that required hospitalization

Researchers compared the characteristics of fully vaccinated and boosted and unvaccinated patients requiring hospitalization for COVID-19.

10 Jan 2022

SARS-CoV-2 Delta binds more strongly to furin protease than other existing variants

Researchers conducted a computational analysis of the furin cleavage domain (FCD) of SARS-CoV-2 and its variants, as well as several other viruses.

10 Jan 2022

Isolated antibodies from BNT162b2 vacinee effective against Omicron variant

Researchers screened BNT162b2 COVID-19 vaccine recipients and cloned broadly neutralizing antibodies from an elite vaccinee.

10 Jan 2022

New genetic mechanism that can cause severe male infertility identified

Scientists at Newcastle University have identified a new genetic mechanism that can cause severe forms of male infertility.

10 Jan 2022

SARS-CoV-2 viral mutations shown to have a limited effect on T cell immunity

New research suggests that viral mutations have a minimal effect on T cell immunity, which could explain the protection provided by vaccination against severe COVID-19, despite the significant loss of neutralizing antibodies.

10 Jan 2022

SARS-CoV-2 Omicron variant's infectivity, vaccine breakthrough, and antibody resistance

A recent study uses an artificial intelligence model to investigate Omicron's mutations and its infectivity, vaccine escape capability, and susceptibility to monoclonal antibodies.

10 Jan 2022

SARS-CoV-2 shown to spread through cell-to-cell transmission

A new study investigated SARS-CoV-2 cell-to-cell transmission in the context of cell-free infection and compared it to SARS-CoV.

10 Jan 2022

Strategy for capturing SARS-CoV-2 through functionalized cellulose materials

Researchers from Northeastern University have developed a new, more cost-effective method for immobilizing SARS-CoV-2.

10 Jan 2022

SARS-CoV-2 Delta sublineage AY.4.2 shows no increase in cell entry or antibody evasion

Researchers from Germany, in their recent study published in the journal Cellular & Molecular Immunology, have evaluated the mutations in the S protein of one such SARS-CoV-2 strain, a Delta sublineage AY.4.2, which is currently expanding in the UK, and have found that it neither contains any potential for increased cell entry nor antibody escape.

10 Jan 2022

SARS-CoV-2 Omicron variant uses endosomal entry pathway and grows in upper respiratory tract cells

Researchers demonstrate that the SARS-CoV-2 Omicron variant grows rapidly in human primary nasal epithelial cultures.

9 Jan 2022

Emerging SARS-CoV-2 B.1.619 and B.1.620 variants in South Korea

Researchers investigate the spread and transmission ability of SARS-CoV-2 lineages B.1.619 and B.1.620 in South Korea.

9 Jan 2022

SARS-CoV-2 Omicron a product of offensive evolution with compromised antigenicity

Researchers investigate the relationship between the SARS-CoV-2 Omicron variant and immune system based on self/nonself short constituent sequences.

9 Jan 2022

Dual-receptors help widespread dissemination of SARS-CoV-2

Researchers demonstrate the role of integrins in the establishment of the SARS-CoV-2 infection.

9 Jan 2022

Vaccinated mothers transfer SARS-CoV-2 antibodies to their breastfed infants

Women vaccinated against COVID-19 transfer SARS-CoV-2 antibodies to their breastfed infants, potentially giving their babies passive immunity against the coronavirus, according to University of Massachusetts Amherst research.

7 Jan 2022

Scientists discover antibody that inhibits a broad range of sarbecoviruses

Scientists have discovered an antibody that may lead to more effective treatments against a wide range of sarbecoviruses, the family of viruses that includes the coronavirus SARS-CoV-2 and their variants.

7 Jan 2022

SARS-CoV-2 Omicron variant leads to widespread escape from neutralizing antibody responses

A new study reported the neutralization of Omicron by a large panel of sera collected from convalescent early pandemic, Alpha, Beta, Gamma and Delta infected individuals, as well as among vaccinees receiving three doses of the Oxford/AstraZeneca (AZD1222) or the Pfizer BioNtech (BNT16b2) vaccines.

7 Jan 2022

Study provides deeper insights into familial Alzheimer's disease pathogenesis

Alzheimer's disease (AD) is a progressive neurological disease that causes impairments in memory and cognition. AD is believed to result from the deposition of protein "plaques" consisting of amyloid beta (Aβ) proteins sequentially generated via the enzyme γ-secretase.

7 Jan 2022

Researchers isolate Omicron variant, leveling the path to vaccine development and vaccine efficacy studies

Researchers from India have now successfully grown and isolated the Omicron variant from hamsters in vivo with further culturing in the Vero CCL-81 cells in vitro, in a step forward towards testing the effectiveness of existing SARS-CoV-2 vaccines and generation of new Omicron appropriate vaccines.

7 Jan 2022

Broad cross-neutralization antibodies found to be effective against SARS-CoV-2 Omicron variant

A new study aimed to explore whether there is a way to induce the production of potent neutralizing antibodies capable of neutralizing all SARS-CoV-2 variants - including Omicron.

7 Jan 2022

Mutation News and Research

Analyzing the evolution of SARS-CoV-2 RNA polymerase in humans

A study on COVID vaccinated vs. unvaccinated that required hospitalization

SARS-CoV-2 Delta binds more strongly to furin protease than other existing variants

Isolated antibodies from BNT162b2 vacinee effective against Omicron variant

New genetic mechanism that can cause severe male infertility identified

SARS-CoV-2 viral mutations shown to have a limited effect on T cell immunity

SARS-CoV-2 Omicron variant's infectivity, vaccine breakthrough, and antibody resistance

SARS-CoV-2 shown to spread through cell-to-cell transmission

Strategy for capturing SARS-CoV-2 through functionalized cellulose materials

SARS-CoV-2 Delta sublineage AY.4.2 shows no increase in cell entry or antibody evasion

SARS-CoV-2 Omicron variant uses endosomal entry pathway and grows in upper respiratory tract cells

Emerging SARS-CoV-2 B.1.619 and B.1.620 variants in South Korea

SARS-CoV-2 Omicron a product of offensive evolution with compromised antigenicity

Dual-receptors help widespread dissemination of SARS-CoV-2

Vaccinated mothers transfer SARS-CoV-2 antibodies to their breastfed infants

Scientists discover antibody that inhibits a broad range of sarbecoviruses

SARS-CoV-2 Omicron variant leads to widespread escape from neutralizing antibody responses

Study provides deeper insights into familial Alzheimer's disease pathogenesis

Researchers isolate Omicron variant, leveling the path to vaccine development and vaccine efficacy studies

Broad cross-neutralization antibodies found to be effective against SARS-CoV-2 Omicron variant

Managing vibration in IVF laboratories

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

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