Proliferation News and Research

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Johns Hopkins researchers identify new marker for early detection of colorectal cancers

Johns Hopkins researchers have identified a protein involved in cell proliferation and the development of new blood vessels that could serve as a marker for the early detection of colorectal cancers.

7 Jan 2019

Study elucidates how essential amino acid in humans acts as growth signal for cells

A recent study from the Laxman lab elucidates how a small metabolite and amino acid, methionine, acts as a growth signal for cells, by setting into motion a metabolic program for cell proliferation.

7 Jan 2019

A small protein plays key role in how cancer stem cells differentiate

A jagged little protein appears to be key to how cancer stem cells differentiate and enable metastasis, according to researchers at Rice University and the Duke University School of Medicine.

4 Jan 2019

Study explains effects of aging on endothelial health and vascular regenerative capacity

The endothelium plays an important role in cardiovascular regulation, from blood flow to platelet aggregation, immune cell infiltration and demargination.

28 Dec 2018

Molecule discovery could hold the key to novel gene therapies for skin problems

Scientists at the University of Birmingham have discovered a protein that could hold the key to novel gene therapies for skin problems including psoriasis - a common, chronic skin disease that affects over 100 million people worldwide.

20 Dec 2018

Novel ferrocenyl phosphines developed as potent antimalarial drugs

A team of researchers from the Singapore University of Technology and Design and Nanyang Technological University have developed novel ferrocene-based molecules that impair the malaria parasite's metabolic function leading to parasite death.

20 Dec 2018

Self-powered bandage generates electricity, reduces healing time for skin wounds in rats

Skin has a remarkable ability to heal itself. But in some cases, wounds heal very slowly or not at all, putting a person at risk for chronic pain, infection and scarring. Now, researchers have developed a self-powered bandage that generates an electric field over an injury, dramatically reducing the healing time for skin wounds in rats.

19 Dec 2018

Active ingredient in eye drops shows promise for treating aggressive blood cancer

An active ingredient in eye drops that were being developed for the treatment of a form of eye disease has shown promise for treating an aggressive form of blood cancer. Scientists at the Wellcome Sanger Institute, University of Cambridge, University of Nottingham and their collaborators have found that this compound, which targets an essential cancer gene, could kill leukemia cells without harming non-leukemic blood cells.

19 Dec 2018

Study reveals mechanism behind failed remyelination in MS

Researchers have discovered that in adult stem cells, the activation of a specific transcription factor induces pathological quiescence and that this is deactivated in MS.

18 Dec 2018

Neuroscience-protein that creates borders inside the brain

Boundaries between different regions of the brain are essential for the brain to function. Research to-date has shown that molecular machineries located at the cell membrane such as cell adhesion molecules are responsible for regulating the boundary formation.

18 Dec 2018

Weakened metabolism of immune T cells may account for serious complications in elderly

The elderly suffer more serious complications from infections and benefit less from vaccination than the general population.

14 Dec 2018

Face masks may offer protection against staph bacteria for hog farm workers and their household members

Face masks appear to provide important protection against drug-resistant Staphylococcus aureus bacteria for hog farm workers and for household members to whom they might otherwise transmit the bacteria, according to a study led by scientists at Johns Hopkins Bloomberg School of Public Health.

14 Dec 2018

Unraveling the complexity of cancer biology can prompt new avenues for drug development

Unraveling the complexity of cancer biology can lead to the identification of new molecules involved in breast cancer and prompt new avenues for drug development. And proteogenomics, an integrated, multipronged approach, seems to be a way to do it.

13 Dec 2018

Research findings could lead to new targets for cancer-fighting therapeutics

A molecular pathway that's frequently mutated in many different forms of cancer becomes active when cells push parts of their membranes outward into bulging protrusions, Johns Hopkins researchers report in a new study.

11 Dec 2018

Natural flavonoid is effective at treating leishmanisis infections, study shows

Current treatment options for the parasitic disease leishmaniasis are largely ineffective, expensive, and tend to be plagued by resistant parasites and side effects. Now, researchers reporting in PLOS Neglected Tropical Diseases have showed that a natural flavonoid is effective at treating Leishmania amazonensis infections.

11 Dec 2018

Scientists discover cellular mechanism that triggers pneumonia in humans

The situation is relatively common, especially in winter. You come down with the flu, which lasts longer than usual. A few days later, you discover you have pneumonia.

10 Dec 2018

Breast tumors recruit bone marrow cells to boost their growth, study reveals

Tel Aviv University researchers have discovered that breast cancer tumors boost their growth by recruiting stromal cells that originate in bone marrow.

10 Dec 2018

Study evaluates placental mesenchymal stem cell sheets for myocardial repair and regeneration

The placenta offers an abundant source of placenta-derived mesenchymal stem cells (pMSCs), which a new study has shown can readily form cell sheets that could be implanted in children with congenital heart defects and offer benefits for heart repair and regeneration compared to commonly used synthetic material-based scaffolds. Congenital heart disease is the leading cause of birth-defect-related illness and death.

9 Dec 2018

New technology for profiling genetic makeup of myeloma tumor cells developed

Cancer arises when cells lose control. Deciphering the "blueprint" of cancer cells - outlining how cancer cells hijack specific pathways for uncontrolled proliferation - will lead to more efficient ways to fight it.

7 Dec 2018

New EU-funded project provides insight into how the brain develops

The human brain is comprised of billions of different types of cells. These cells are then organized into sophisticated networks, each of which determines a specific function of the brain. But how do the neurons, or nerve cells that form these networks, find the right network? And what happens when they don’t?

6 Dec 2018