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New vaccine candidate with RBD and N protein targets protects against SARS-CoV-2 in preclinical trials

A recent study published in the journal Science Advances, explores the immunization of RBD with the P2 epitope of tetanus toxoid, to enhance its immunogenicity, and also tests the benefit of N protein in the vaccine.

2 Jun 2021

Synthetic microRNA can serve as a novel therapeutic agent for treating human cancer

Oncotarget published "Multi-modal effects of 1B3, a novel synthetic miR-193a-3p mimic, support strong potential for therapeutic intervention in oncology" which reported that the authors comprehensively investigated miRNA-193a-3p's mode of action in a panel of human cancer cell lines, with a variety of genetic backgrounds, using 1B3, a synthetic microRNA mimic

2 Jun 2021

Depleting SIRPα-deficient in macrophages activate tumor antigen-specific cytotoxic T cells

In a study that will be published in Nature Communications on May 28, 2021, a research team led by Dr. Yuan Liu from Georgia State University reports that intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells to eliminate various syngeneic cancers under radiotherapy.

2 Jun 2021

Study reveals deep impact of superficial skin inking

Announcing a new article publication for BIO Integration journal. In this article the authors Craig S. Carlson and Michiel Postema, from University of the Witwatersrand, Johannesburg, South Africa and Tampere University, Tampere, Finland discuss deep impact of superficial skin inking: acoustic analysis of underlying tissue.

2 Jun 2021

Nanoscale coordination polymers show promise for efficient dopamine delivery in Parkinson's treatment

Parkinson's disease (PD) is a common neurodegenerative disorder caused by the death of dopaminergic neurons in a part of the brain (known as substantia nigra pars compacta), which leads to a deficit of dopamine (DA), one of the main neurotransmitters active in the central nervous system.

1 Jun 2021

The LUCA device shows high accuracy in thyroid cancer screening

Thyroid nodules are a common pathology having a prevalence of 19-76% when screened with ultrasound, with higher frequencies in women.

1 Jun 2021

ALG-097111 potently inhibits SARS-CoV-2 replication in Syrian Hamster model in vivo

A team of researchers from the US and Belgium applied a structure-based approach with early monitoring of cathepsin L inhibition along with SARS-CoV-2 3CLpro inhibition. They identified a potent and selective SARS-CoV-2 3CLpro inhibitor, ALG-097111, which has proven activity against SARS-CoV-2 in SARS-CoV-2 hamster models in vivo. This study is published in the journal, Biochemical and Biophysical Research Communications.

1 Jun 2021

AMSBIO's custom lentivectors for labeling organoids

AMSBIO have supplied custom lentivectors to Francesco Pampaloni and his team at the Buchmann Institute for Molecular Life Sciences in Frankfurt, Germany allowing them to visualize cell nuclei and F-actin cytoskeleton in their organoids.

From AMS Biotechnology 1 Jun 2021

Researchers repurpose pre-existing anti-SARS-CoV antibody to develop potent neutralizing antibody against SARS-CoV-2

A team of scientists from the United States has recently engineered a pre-existing anti-severe acute respiratory syndrome coronavirus (SARS-CoV) neutralizing antibody to increase its binding affinity for the spike receptor-binding domain (RBD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The engineered antibody demonstrates high potency in neutralizing SARS-CoV-2 and preventing infection in animals.

31 May 2021

Harnessing DNA’s properties to craft “‘topologically tunable” DNA-based materials

While DNA is often idealized as the "molecule of life", it is also a highly sophisticated polymer that can be used for next-generation materials. Beyond the fact that it can store information, further fascinating aspects of DNA are its geometric and topological properties, such as knotting and super-coiling.

31 May 2021

Kinase inhibitors could provide an effective way to treat high-risk leukaemia

Australian scientists have found what could prove to be a new and effective way to treat a particularly aggressive blood cancer in children.

29 May 2021

New system can measure propofol concentration in patient's blood during surgery

Anesthesia may be an exact science, but it's not yet fully personalized. Anesthesiologists use a variety of methods to calculate the right dose for a given patient: clinical studies, medical databases and laboratory measurements, for example. However, every individual responds to anesthetics in a different way, and there's no way of knowing what that response will be until the anesthetic is administered.

29 May 2021

Study shows that breast cancer can be prevented with better contraception choices

Hormonal contraceptives, e.g. the pill, the patch, and the vaginal ring, contain synthetic hormones that prevent pregnancy by either stopping ovulation, changing the cervical mucus to stop sperm from passing through the cervix and finding an egg, or changing the womb's lining to prevent a fertilized egg from being implanted in it.

29 May 2021

Corning launches HepGo Assay-ready 3D liver spheroid kit

Corning Incorporated today announced the launch of its HepGo™ Assay-ready 3D liver spheroid kit, the first plug-and-play solution to include 96 pre-plated primary human hepatocyte (PHH) spheroids in a single-spheroid microplate (one uniform spheroid per well) and HepGo Hepatocyte companion cell culture media.

28 May 2021

Could the marine compound plitidepsin promote recovery from moderate COVID-19?

A new paper by an international team of researchers describes experimental evidence of the antiviral efficacy of a marine compound called plitidepsin against SARS-CoV-2. The findings show that plitidepsin inhibits SARS-CoV at low concentrations, as observed by a thousand-fold reduction in genomic RNA and viral titers in cells exposed to the virus in culture when treated.

27 May 2021

Nanobody inhalation found to be effective against COVID-19 in hamsters

In a recent paper, researchers describe an aerosolized nanobody formulation that was found to effectively block SARS-CoV-2 in Syrian hamsters.

27 May 2021

EU project to investigate impact and consequences of micro and nanoplastics on human health

PLASTICHEAL project will develop new methodologies and will provide reliable scientific evidence for regulators to set the knowledge basis for adequate risk assessment. The results will draw a variety of experimental human models and measuring potential health effects under short and long-term conditions.

27 May 2021

Astodrimer sodium exhibits potent virucidal and antiviral activity against SARS-CoV-2 in vitro

Researchers from the US and Australia recently conducted some studies to assess the in vitro antiviral and virucidal (irreversible) activity of astodrimer sodium against SARS-CoV-2.

26 May 2021

New technology makes it easier to diagnose neurodegenerative diseases

A new combination of optical coherence tomography (OCT), adaptive optics and deep neural networks should enable better diagnosis and monitoring for neuron-damaging eye and brain diseases like glaucoma.

25 May 2021

Repurposed gout medication (probenecid) shows potent inhibition of SARS-CoV-2 replication

New research by a team of scientists in the USA describes the potential utility of a drug called probenecid, commonly used to treat gout, to treat this devastating viral illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the causative virus of COVID-19.

25 May 2021

in vivo News and Research

New vaccine candidate with RBD and N protein targets protects against SARS-CoV-2 in preclinical trials

Synthetic microRNA can serve as a novel therapeutic agent for treating human cancer

Depleting SIRPα-deficient in macrophages activate tumor antigen-specific cytotoxic T cells

Study reveals deep impact of superficial skin inking

Nanoscale coordination polymers show promise for efficient dopamine delivery in Parkinson's treatment

The LUCA device shows high accuracy in thyroid cancer screening

ALG-097111 potently inhibits SARS-CoV-2 replication in Syrian Hamster model in vivo

AMSBIO's custom lentivectors for labeling organoids

Researchers repurpose pre-existing anti-SARS-CoV antibody to develop potent neutralizing antibody against SARS-CoV-2

Harnessing DNA’s properties to craft “‘topologically tunable” DNA-based materials

Kinase inhibitors could provide an effective way to treat high-risk leukaemia

New system can measure propofol concentration in patient's blood during surgery

Study shows that breast cancer can be prevented with better contraception choices

Corning launches HepGo Assay-ready 3D liver spheroid kit

Could the marine compound plitidepsin promote recovery from moderate COVID-19?

Nanobody inhalation found to be effective against COVID-19 in hamsters

EU project to investigate impact and consequences of micro and nanoplastics on human health

Astodrimer sodium exhibits potent virucidal and antiviral activity against SARS-CoV-2 in vitro

New technology makes it easier to diagnose neurodegenerative diseases

Repurposed gout medication (probenecid) shows potent inhibition of SARS-CoV-2 replication

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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