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Alecensa (alectinib) approved for treatment of people with advanced ALK-positive NSCLC

The U.S. Food and Drug Administration today approved Alecensa (alectinib) to treat people with advanced (metastatic) ALK-positive non-small cell lung cancer (NSCLC) whose disease has worsened after, or who could not tolerate treatment with, another therapy called Xalkori (crizotinib).

11 Dec 2015

Early promise for pulmonary artery denervation in PAH patients

Pulmonary artery denervation is feasible and may reduce pulmonary arterial pressure in patients with pulmonary arterial hypertension, phase II findings suggest.

11 Dec 2015

Post-progression afatinib exposure boosts NSCLC outcomes

Continued exposure to afatinib plus paclitaxel can benefit non-small-cell lung cancer patients who developed resistance to erlotinib or gefitinib and progressed after initially responding to afatinib monotherapy, suggest phase III trial results.

11 Dec 2015

$Role for carfilzomib in relapsed, refractory multiple myeloma treatment$

Role for carfilzomib in relapsed, refractory multiple myeloma treatment

Carfilzomib significantly improves outcomes in previously treated patients with relapsed or refractory multiple myeloma, shows a head-to-head comparison with bortezomib.

11 Dec 2015

Androgen deprivation therapy elevates Alzheimer’s risk

US researchers find that androgen deprivation therapy increases the risk of Alzheimer’s disease in men with prostate cancer, with the risk rising with greater duration of therapy.

11 Dec 2015

Sangamo presents Phase 2 data from two ongoing clinical trials of SB-728-T for treatment of HIV/AIDS

Sangamo BioSciences, Inc., the leader in therapeutic genome editing, announced the presentation of Phase 2 data from two of the Company's ongoing clinical trials (SB-728-1101 Cohort 3* and SB-728-mR-1401) of SB-728-T, which is being developed for the functional control of HIV/AIDS.

11 Dec 2015

ER stroke cases have some degree of preventability, UCI study shows

Many strokes that required immediate treatment in emergency rooms may have been preventable, according to a University of California, Irvine study.

11 Dec 2015

FDA grants Fast Track status to Cardiorentis' Ularitide for treatment of ADHF

Cardiorentis AG, a privately held biopharmaceutical company, today announced that the U.S. Food and Drug Administration has granted Fast Track status to Ularitide, an investigational therapy for the treatment of acute decompensated heart failure (ADHF).

11 Dec 2015

Findings may lead to new treatment strategy for phobia

A new study published in the latest issue of Biological Psychiatry reports the successful and instant reduction of fear in spider-fearful participants following a 2-minute exposure combined with a single dose of a regular pharmacological treatment.

11 Dec 2015

Adjuvant chemotherapy not beneficial for patients with luminal A subtype of breast cancer

Premenopausal women whose invasive breast cancers were of the luminal A subtype had comparable 10-year disease-free survival rates regardless of whether or not they received adjuvant chemotherapy, according to data from the phase III DBCG77B clinical trial presented at the 2015 San Antonio Breast Cancer Symposium, held Dec. 8-12.

11 Dec 2015

Capecitabine increases disease-free survival for HER2-negative breast cancer patients

Treatment with the chemotherapy agent capecitabine increased disease-free survival for women with HER2-negative breast cancer that was not eliminated by presurgery chemotherapy, according to results from the phase III CREATE-X clinical trial presented at the 2015 San Antonio Breast Cancer Symposium, held Dec. 8-12.

11 Dec 2015

Study reveals why anti-hormone therapy tamoxifen works better in some women than others

The anti-hormone therapy tamoxifen can reduce breast cancer recurrence by about half in women with hormone-sensitive breast cancer. But it works better in some women than others. Researchers are not sure why.

11 Dec 2015

Virologists demonstrate how poxviruses defeat the body's host immune defenses

Smallpox virus, which killed millions of humans through the ages, ranks among the world's most feared bioterrorism agents. Human monkeypox continues to occur sporadically in remote African villages.

11 Dec 2015

Providing novice surgeons with regular feedback can help prevent blood clots among hospitalized patients

A study of general surgery residents at The Johns Hopkins Hospital suggests that in the efforts to prevent dangerous blood clots among hospitalized patients, regular, one-on-one feedback and written report cards work a lot better than the usual group lectures that newly minted surgeons receive as part of their training.

11 Dec 2015

Study may help guide patients and physicians to determine appropriate treatment option for early breast cancer

In a review of guideline-concordant treatment modalities for women with early stage breast cancer, mastectomy and reconstruction had the highest rate of complications and complication-related costs, regardless of age. It was also the most expensive treatment option in a younger patient population, according to a new study from The University of Texas MD Anderson Cancer Center.

11 Dec 2015

Postponing chemotherapy may increase risk of death for triple-negative breast cancer patients

Postponing the start of adjuvant chemotherapy for more than 90 days following surgery may significantly increase risk of death for breast cancer patients, particularly those with triple-negative breast cancer (TNBC), according to a new study from The University of Texas MD Anderson Cancer Center.

11 Dec 2015

Videregen-led TETRA consortium awarded EUR 6.8 million for pivotal Phase II trial of replacement trachea

The pan-European TETRA consortium, led by Videregen Limited, has been awarded EUR 6.8 million under the Horizon 2020 programme for a pivotal Phase II clinical trial of the company's tissue engineered replacement trachea.

10 Dec 2015

Circuit awarded contract to pursue optogenetic therapies for peripheral nervous system indications

Circuit Therapeutics today announced that it has been awarded a 2.7 million dollar contract from the Defense Advanced Research Projects Agency to pursue optogenetic therapies for peripheral nervous system indications. The award, part of DARPA's Electrical Prescriptions (ElectRX) program, will enable Circuit to pursue research and development projects related to its treatment for neuropathic pain.

10 Dec 2015

Human heart can fully recover after massive damage

The scientists report the case of a newborn that had suffered a massive heart attack in the first hours of life. It was caused by a blockage in a vital coronary vessel. "The baby's heart was severely damaged. Astonishingly, the baby recovered very quickly," said Bernhard Haubner, a cardiologist and researcher, and his colleague, Johanna Schneider, in an article just published in the journal "Circulation Research".

10 Dec 2015

WHO launches new comprehensive analysis of global health trends

The World Health Organization (WHO) today launched a new comprehensive analysis of global health trends since 2000 and an assessment of the challenges for the next 15 years.

10 Dec 2015

Therapy News and Research

Alecensa (alectinib) approved for treatment of people with advanced ALK-positive NSCLC

Early promise for pulmonary artery denervation in PAH patients

Post-progression afatinib exposure boosts NSCLC outcomes

Role for carfilzomib in relapsed, refractory multiple myeloma treatment

Androgen deprivation therapy elevates Alzheimer’s risk

Sangamo presents Phase 2 data from two ongoing clinical trials of SB-728-T for treatment of HIV/AIDS

ER stroke cases have some degree of preventability, UCI study shows

FDA grants Fast Track status to Cardiorentis' Ularitide for treatment of ADHF

Findings may lead to new treatment strategy for phobia

Adjuvant chemotherapy not beneficial for patients with luminal A subtype of breast cancer

Capecitabine increases disease-free survival for HER2-negative breast cancer patients

Study reveals why anti-hormone therapy tamoxifen works better in some women than others

Virologists demonstrate how poxviruses defeat the body's host immune defenses

Providing novice surgeons with regular feedback can help prevent blood clots among hospitalized patients

Study may help guide patients and physicians to determine appropriate treatment option for early breast cancer

Postponing chemotherapy may increase risk of death for triple-negative breast cancer patients

Videregen-led TETRA consortium awarded EUR 6.8 million for pivotal Phase II trial of replacement trachea

Circuit awarded contract to pursue optogenetic therapies for peripheral nervous system indications

Human heart can fully recover after massive damage

WHO launches new comprehensive analysis of global health trends

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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