Mouse Model News and Research

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Vaping may impair fertility and pregnancy outcomes

E-cigarette usage may impair fertility and pregnancy outcomes, according to a mouse study published in the Journal of the Endocrine Society.

5 Sep 2019

Zika virus damages the adult human brain and impairs memory in mouse model

Zika virus attracted worldwide attention in recent years due to the devastating consequences of infection for pregnant women and their fetuses, many of which were born with microcephaly and other severe neurological malformations.

5 Sep 2019

Resistance to 'hunger hormone' linked with cognitive impairments and memory loss

Scientists at The University of Texas at Dallas have found evidence suggesting that resistance to the "hunger hormone" ghrelin in the brain is linked to the cognitive impairments and memory loss associated with Alzheimer's disease.

4 Sep 2019

New study helps explain why lung tumors turn aggressive

Lung cancer is the number 1 killer among cancers, especially when it is of the non-small cell type. Among these, adenocarcinomas are the most common and aggressive type. These tumors also show a strong tendency to show dedifferentiation, or loss of the features that characterize a mature lung cell.

28 Aug 2019

Scientists identify PoEMs that promote breast cancer metastasis

When breast cancer cells spread through the body, they do so mainly through the lymph system that normally removes excess fluid and waste products from our tissues.

28 Aug 2019

New cellular processes controlling the formation of lymphatic valves found

Lymphedema, resulting from a damaged lymphatic system, can be a debilitating disease in which excess protein-rich fluid (lymph) collects in soft tissues and causes swelling -- most often in the arms or legs.

28 Aug 2019

Study shows microRNA can protect the heart from reperfusion injury

Heart muscle can continue to die even after restoring blood following a heart attack, and scientists have new evidence that one way to help it live is by boosting levels of a tiny RNA that helped the heart form.

27 Aug 2019

Remodeling unhealthful gut microbiomes with the help of synthetic peptides

You are what you eat - right down to the microbiome living in your gut. Diet can affect which microbes are in the intestinal tract, and research has shown that harmful gut microbiome changes can lead to illnesses such as heart disease, obesity and cancer.

27 Aug 2019

Salk researchers develop new gene-editing tool to target broad range of mutations, cell types

The ability to edit genes in living organisms offers the opportunity to treat a plethora of inherited diseases. However, many types of gene-editing tools are unable to target critical areas of DNA, and creating such a technology has been difficult as living tissue contains diverse types of cells.

26 Aug 2019

New study reveals exosome-mediated communication between mother and baby

During pregnancy, the mother and the baby communicate in a variety of ways. For instance, signals from the fetus are crucially involved in the initiation of labor and delivery.

22 Aug 2019

Enzyme induced by stress associated with liver cancer growth

An enzyme induced by stress to help reduce production of damaging free radicals is also used by liver cancer to regulate two major cell proliferation pathways that enable the cancer to thrive, scientists report.

22 Aug 2019

Meat allergy triggered by tick bites explained

Researchers from University of Virginia School of Medicine have uncovered the mystery behind development of allergic reactions to red meat such as beef in some individuals. Recently there has been a body of research on allergies to meat developing in individuals due to tick bites.

21 Aug 2019

Next generation of hydrogel systems could help repair bone defects in future

Bioengineers and dentists from the UCLA School of Dentistry have developed a new hydrogel that is more porous and effective in promoting tissue repair and regeneration compared to hydrogels that are currently available.

20 Aug 2019

Study: Blocking inflammatory pathway could prevent melanoma brain metastasis

Brain metastases are among the deadliest tumor metastases, with a median survival period of less than one year, and the incidence of brain metastasis is rising.

20 Aug 2019

Loss of cells in the brain found to be associated with stuttering

Researchers believe that stuttering - a potentially lifelong and debilitating speech disorder - stems from problems with the circuits in the brain that control speech, but precisely how and where these problems occur is unknown.

19 Aug 2019

Liver dysfunction provokes cerebral molecular disturbances in two weeks

The liver plays a vital role as a filter in the human body. But what happens when it malfunctions? Researchers from the Universities of Geneva and Lausanne, the Vaud University Hospital Centre, the Centre for Biomedical Imaging, the Federal Polytechnic School of Lausanne and the University Hospitals of Geneva, Switzerland, teamed up to perform a detailed analysis of hepatic encephalopathy, a type of brain damage caused by chronic liver disease.

19 Aug 2019

Stress inhibits eating behavior

Many human beings can’t swallow a thing when faced with significant stress, among other strong emotional states. However, scientists don’t know much about how the brain brings about these emotion-related effects on eating behavior.

19 Aug 2019

Researchers discover how stress can decrease the desire to eat

Eating disorder researchers at The University of Texas Health Science Center at Houston (UTHealth) have discovered a neurocircuit in mice that, when activated, increased their stress levels while decreasing their desire to eat. Findings appear in Nature Communications.

18 Aug 2019

Machine learning reveals links between genetic factors and behavior

Researchers have used machine learning to start making links between seemingly instinctive, random behaviors and genetic factors.

15 Aug 2019

Removing single enzyme improves outcomes in mouse model of sepsis

Sepsis occurs when the body goes overboard in its attempt to fight off an infection. Immune cells rush in, overreact and wreak havoc on tissues and organs, often resulting in organ failure and death.

14 Aug 2019