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‘Sushi-like’ nanodiscs provide structural snapshots of misfolding proteins

When proteins misfold, accumulate and clump around insulin-producing cells in the pancreas, they kill cells. Now, researchers, including University of Michigan biophysicists, have obtained a structural snapshot of these proteins when they are most toxic, detailing them down to the atomic level.

15 Dec 2017

New discovery could speed up production of cells for studying diseases

Scientists have made a key discovery that could speed up the production of cells in the lab for studying diseases such as multiple sclerosis and Parkinson's disease.

28 Nov 2017

Newcastle scientists develop new technique that revolutionizes cell culture

A technique which revolutionizes cell culture by allowing the continuous production and collection of cells, has been developed by scientists at Newcastle University.

28 Nov 2017

Diabetes patients’ immune system can regulate insulin production

Inflammation processes are responsible for the failure of insulin production in diabetes patients. The patients' own immune systems can contribute to treatment of this disease: researchers at the University of Basel and University Hospital Basel have found a feedback mechanism that could help maintain insulin production in overweight sufferers, as they report in the journal Immunity.

21 Nov 2017

Common ingredient in laundry detergents may help build bioartificial pancreas to cure type 1 diabetes

Two oxygen-producing compounds – including one that boosts performance in some laundry detergents – might one day play a key role in helping scientists successfully build a bioartificial pancreas in the lab to cure type 1 diabetes.

16 Nov 2017

Scientists uncover mechanism that prevents tumor growth in melanoma

Natural Killer (NK) cells, lymphocytes of the innate immune system with strong cytotoxic activity, play a major role in the immune response against tumors.

8 Nov 2017

Popular Alzheimer's drug shows promise in clinical trials for treating patients with sickle cell disease

A popular drug commonly used to treat Alzheimer's disease has shown promise in laboratory and clinical trials for treating patients with sickle cell disease (SCD).

7 Nov 2017

New research disproves using anti-malaria drug for diabetes treatment

A drug used to treat malaria does not, after all, create new insulin-producing cells, according to a new paper from researchers at the University of California, Davis. The work, published in Cell Metabolism Nov. 2, refutes a study published in Cell in January.

3 Nov 2017

Targeting blood-clotting protein may help treat multiple sclerosis and other diseases

Picture a bare wire, without its regular plastic coating. It's exposed to the elements and risks being degraded. And, without insulation, it may not conduct electricity as well as a coated wire. Now, imagine this wire is inside your brain.

2 Nov 2017

Study demonstrates beneficial effects of calorie-restricted diet in mice

Caloric restriction diets have been associated with various health benefits, but their effects on the skin have not been previously demonstrated. Research conducted at the University of São Paulo (USP) in Brazil shows that controlling calories helps mice live longer, although it reduces the reserves of fat in adipose tissue needed to keep the body warm.

30 Oct 2017

Longevity Biotech receives award to evaluate novel drug candidate for MS in preclinical models

Longevity Biotech, Inc. has received an award from the National Multiple Sclerosis Society through Fast Forward, the Society's commercial research funding program, to evaluate LBT-3627 in preclinical models as a potential disease-modifying therapeutic agent.

28 Oct 2017

Powering up fat cells could help acute myeloid leukemia patients

Killing cancer cells indirectly by powering up fat cells in the bone marrow could help acute myeloid leukemia patients, according to a new study from McMaster University.

16 Oct 2017

UAB researchers detail underlying mechanism leading to age-associated osteoporosis

A major health problem in older people is age-associated osteoporosis -- the thinning of bone and the loss of bone density that increases the risk of fractures. Often this is accompanied by an increase in fat cells in the bone marrow.

22 Sep 2017

Research sheds light on how to improve production of key diabetes cells

Beta cells release insulin in your blood, but when you suffer from Type 1 diabetes, you hardly have any of them left in your body. This is because the immune system attacks the beta cells.

21 Sep 2017

MIT engineers design more effective synthetic mRNA delivery system

By delivering strands of genetic material known as messenger RNA into cells, researchers can induce the cells to produce any protein encoded by the mRNA. This technique holds great potential for administering vaccines or treating diseases such as cancer, but achieving efficient delivery of mRNA has proven challenging.

21 Sep 2017

Oxytocin promotes avoidance of unfamiliar situations after negative social interactions

Before you shop for the "cuddle" hormone oxytocin to relieve stress and enhance your social life, read this: a new study from the University of California, Davis, suggests that sometimes, blocking the action of oxytocin in the brain may be a better option.

20 Sep 2017

University Of Minnesota scientists describe breakthrough in research related to FSHD

A new study published in the journal Nature Communications describes a breakthrough in research related to facioscapulohumeral muscular dystrophy (FSHD). The debilitating genetic disease - which has no approved treatment - affects an estimated 38,000 Americans and causes degeneration and wasting of the skeletal muscles.

15 Sep 2017

Researchers overcome major stumbling blocks in developing HIV vaccine

An international team of researchers has demonstrated a way of overcoming one of the major stumbling blocks that has prevented the development of a vaccine against HIV: the ability to generate immune cells that stay in circulation long enough to respond to and stop virus infection.

13 Sep 2017

Researchers investigate link between thyroid hormone and red blood cell production

For more than a century, physicians have anecdotally noted that patients with an underactive thyroid - often caused by iodine deficiency - tended to also have anemia. But the link between thyroid hormone and red blood cell production has remained elusive.

6 Sep 2017

Targeting bone marrow protein could be effective way to improve stem cell transplants

Bone marrow contains hematopoetic stem cells, the precursors to every blood cell type. These cells spring into action following bone marrow transplants, bone marrow injury and during systemic infection, creating new blood cells, including immune cells, in a process known as hematopoiesis.

28 Aug 2017