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Obesity alters tumor environment promoting invasive breast cancer growth

Obesity may change how early-stage breast cancer becomes invasive, according to a study by University of Oklahoma researchers published in The American Journal of Pathology.

28 May 2026

Scientists identify new therapeutic target for deadly prostate cancer

Researchers at Columbia University Irving Medical Center have identified a gene that drives the development of neuroendocrine prostate cancer (NEPC), an aggressive form of the disease.

28 May 2026

Scientists develop safer CRISPR technique using gentler DNA nicking approach

Researchers at Cornell University have developed a safer and more precise way to study how genes function in living tissues by refining a recently developed CRISPR-based genetic technique in fruit flies, enabling researchers to better study how genes contribute to development and disease.

27 May 2026

Ghrelin rises in depression despite obesity’s usual appetite-hormone suppression

Researchers found that both acylated and deacylated ghrelin were elevated in unmedicated adults with major depressive disorder and obesity compared with non-depressed adults with obesity. The cross-sectional findings suggest ghrelin-system dysregulation may be linked to depression in obesity, but larger longitudinal studies are needed to test whether ghrelin is a reliable biomarker.

27 May 2026

Surface acids found crucial for bacterial shape and growth

Researchers have discovered how acids on the surface of bacteria give these microscopic organisms their characteristic "rod" shape-by keeping an enzyme at bay that would otherwise turn the cylindrical cells into shape-shifting blobs.

26 May 2026

Estrogen decline alters brain cell matrix in older females

A largely overlooked space between cells in women's brains may hold the key to understanding memory loss tied to estrogen decline after menopause, reports a new preclinical Northwestern Medicine study.

26 May 2026

Silica nanoparticles dampen early allergy signals in mouse mast cells

This in vitro study found that negatively charged SiO2 nanoparticles suppressed antigen-induced degranulation and activation-marker changes in IgE-sensitized mouse bone marrow-derived mast cells. By contrast, mTiO2 nanoparticles showed cytotoxic and pro-inflammatory effects, including enhanced DNP-induced IL-6 release, suggesting nanoparticle composition can shape early allergic immune responses.

24 May 2026

Scientists visualize a key cell protein regulating inflammatory disease pathways

University of Cincinnati structural biologists are the first in the world to visualize a key cell protein as part of newly published research from the College of Medicine.

22 May 2026

Bioinformatics accelerates discovery of marine-derived bioactive therapeutic peptides

Marine organisms have evolved a remarkable arsenal of host-defense peptides under conditions of extreme variability and constant pathogen exposure. Generally defined as short chains of 2 to 20 amino acid residues, these molecules have become a focal point for biomedicine, food science, and materials science.

22 May 2026

Targeting lipid enzymes triggers starvation states in aggressive tumor cells

While many American adults are trying to reduce cholesterol levels, certain cancerous tumors have a relentless appetite for the metabolite.

22 May 2026

NIH researchers discover how weight-loss drugs alter brain cells

A team of researchers at the National Institutes of Health (NIH) have unveiled new details about the events GLP-1 receptor agonists trigger within neurons, which have been largely unexplored until now.

22 May 2026

What medicine-exposed rats reveal about the next urban zoonotic threat

Researchers found that more than half of urban rats sampled from low-income communities in Salvador, Brazil, carried active pharmaceutical ingredients in their brain tissue. These pollutants were associated with altered zoonotic infection patterns, including lower Leptospira infection probability in rats carrying azithromycin and higher Capillaria infection probability in rats carrying citalopram.

22 May 2026

New study reveals nitric oxide’s widespread impact on genetics

Genes undergo extensive editing through a process called alternative splicing, which greatly increases the size of the functional genome, the working portion of our DNA that helps make each person unique. Put simply, a single gene can be edited in different ways to produce multiple sets of instructions.

22 May 2026

Researchers discover how overpopulation reduces fertility

Scientists have reported it for decades: Overpopulation can impair reproduction.

21 May 2026

Bioluminescent fungi reveal pathways for advanced biotechnology and medical applications

Like fireflies and many deep-sea creatures, certain fungi can naturally emit light through bioluminescence pathways in which specialized enzymes convert chemical energy into visible light.

21 May 2026

Restoring ADAR2 enzyme reduces metastatic spread in osteosarcoma

Osteosarcoma is the most common primary bone cancer in children, adolescents, and young adults. Although chemotherapy and surgery have improved survival for localized disease, outcomes remain poor when tumors spread to the lungs or return after treatment.

20 May 2026

MIDAS platform accelerates protein engineering through rapid PCR-based screening

Proteins are critical to life – and to industry. There are countless proteins that could be engineered to treat and even cure serious diseases and cellular dysfunctions.

19 May 2026

DNA-guided CRISPR system targets RNA and expands Cas12 beyond gene editing

Researchers developed ΨDNA, a DNA-based CRISPR guide that allows Cas12 enzymes to target RNA with high specificity while retaining compatibility with DNA-editing workflows. The platform detected HCV RNA in clinical samples and enabled programmable RNA knockdown, multiplex targeting, and RNA modification in human cells.

18 May 2026

New mechanism to enhance precision in cancer drug development

Researchers at The University of Texas Medical Branch (UTMB) have identified how a key enzyme called ATR protects DNA from breaking when cells copy damaged genetic material, a discovery that could affect how certain cancer drugs are developed.

15 May 2026

Researchers develop pH and redox-sensitive systems to reduce immunotherapy toxicity

Although cancer immunotherapy has transformed treatment by harnessing the immune system to eliminate tumors, only a small subset of patients benefit. Many solid tumors remain "cold," characterized by poor immune cell infiltration and resistance to immune checkpoint blockade (ICB).

15 May 2026

Enzyme News and Research

Obesity alters tumor environment promoting invasive breast cancer growth

Scientists identify new therapeutic target for deadly prostate cancer

Scientists develop safer CRISPR technique using gentler DNA nicking approach

Ghrelin rises in depression despite obesity’s usual appetite-hormone suppression

Surface acids found crucial for bacterial shape and growth

Estrogen decline alters brain cell matrix in older females

Silica nanoparticles dampen early allergy signals in mouse mast cells

Scientists visualize a key cell protein regulating inflammatory disease pathways

Bioinformatics accelerates discovery of marine-derived bioactive therapeutic peptides

Targeting lipid enzymes triggers starvation states in aggressive tumor cells

NIH researchers discover how weight-loss drugs alter brain cells

What medicine-exposed rats reveal about the next urban zoonotic threat

New study reveals nitric oxide’s widespread impact on genetics

Researchers discover how overpopulation reduces fertility

Bioluminescent fungi reveal pathways for advanced biotechnology and medical applications

Restoring ADAR2 enzyme reduces metastatic spread in osteosarcoma

MIDAS platform accelerates protein engineering through rapid PCR-based screening

DNA-guided CRISPR system targets RNA and expands Cas12 beyond gene editing

New mechanism to enhance precision in cancer drug development

Researchers develop pH and redox-sensitive systems to reduce immunotherapy toxicity

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