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Novel 'tooth-on-a-chip' could open door to personalized dental care

A so-called "tooth-on-a-chip" could one day enable more personalized dentistry, giving dentists the ability to identify dental filling materials that work better and last longer based on a patient's own teeth and oral microbiome.

19 Dec 2019

New combination therapy can lead to durable responses in patients with multiple myeloma

An experimental, off-the-shelf immunotherapy that combines a targeted antibody and chemotherapy can lead to potentially durable responses in multiple myeloma patients whose disease has relapsed or is resistant to other standard therapies.

17 Dec 2019

Newly identified antibody has potential to stop, reverse pulmonary arterial hypertension

Scientists at the University of Sheffield, working in collaboration with drug and vaccine developer Kymab Ltd, Cambridge, have identified a novel antibody that has the potential to become a new treatment for pulmonary arterial hypertension (PAH).

15 Nov 2019

Retinal hyperspectral imaging shows promise for early Alzheimer's disease detection

Alzheimer's disease is the leading cause of dementia in the U.S., with approximately 5.4 million currently affected and an estimated 16 million by 2050.

11 Nov 2019

Study identifies a kinase as potential target to treat heart failure

An unexplored kinase in heart muscle cells may be a good target to treat heart failure, a disease that is only incrementally delayed by existing therapies.

31 Oct 2019

New TB vaccine: mid-phase trials confirm safety, long-term prevention

A new study published on October 29, 2019, in the New England Journal of Medicine, reports a new vaccine which could change the face of tuberculosis prevention. The disease kills 1.5 million people worldwide each year.

30 Oct 2019

Novel approach brings researchers one step closer to universal flu vaccine

The scourge of the influenza virus devastates health and claims many lives worldwide each year. It is especially daunting because vaccines are only protective when they are well matched to the strains circulating in the population.

18 Oct 2019

Tadataka and Leslie Yamada's $10 million gift will fuel new U-M Center for Global Health Equity

For decades, University of Michigan teams have tackled some of the world's toughest health challenges through research, education and global partnership.

17 Oct 2019

Novel therapeutic approach improves survival in patients newly diagnosed with advanced ovarian cancer

An international study demonstrates that administering niraparib after conventional chemotherapy treatment in patients newly diagnosed with advanced ovarian cancer, improves their progression-free survival, and reduces their risk of relapse or death from this disease.

28 Sep 2019

Cancer Research Institute declares 2019 recipients of top scientific and philanthropic awards

The Cancer Research Institute (CRI), a nonprofit organization dedicated to advancing the discovery and development of powerful immunotherapies for all forms of cancer, has announced the 2019 recipients of its highest scientific and philanthropic awards.

27 Sep 2019

Metabolic imbalance in cancer patients associated with resistance to immune checkpoint blocker

A metabolic imbalance in some cancer patients following treatment with a checkpoint inhibitor drug, nivolumab, is associated with resistance to the immunotherapy agent and shorter survival, report scientists from Dana-Farber Cancer Institute, in collaborative work with the Broad Institute of MIT and Harvard.

25 Sep 2019

Researchers reveal skin cream’s true molecular structure

Anyone who has gone through the stress and discomfort of raw, irritated skin knows the relief that comes with slathering on a creamy lotion.

27 Aug 2019

A brush with a notorious cat, my rabies education and the big bill that followed

I was just petting an orange tabby cat in my Falls Church, Va., neighborhood, a cat I’d never met before. He was very cute. And he was purring and butting his head against my hand. Until he wasn't.

20 Aug 2019

New 3D-cardiac tissue platform can predict how heart responds to drugs

Researchers from TARA Biosystems, Inc. and GlaxoSmithKline today published data demonstrating that TARA's engineered heart-on-a-chip system replicated drug responses found in adult humans.

7 Aug 2019

Study investigates whether patients with ADPKD should be screened for brain aneurysms

Autosomal dominant polycystic kidney disease is characterized by progressive development of kidney cysts, as well as abnormalities outside the kidneys, including brain aneurysms or weaknesses in blood vessels in the brain that balloon and fill with blood and may later rupture.

31 Jul 2019

Family members' drugs may be risk factor for overdose in individuals without prescriptions

According to the Centers for Disease Control and Prevention, opioid overdoses were responsible for more than 42,000 deaths in 2016.

17 Jul 2019

FDA approves new treatment for children with lupus

The U.S. Food and Drug Administration today approved Benlysta (belimumab) intravenous infusion for treatment of children with systemic lupus erythematosus – often referred to as simply "lupus" – a serious chronic disease that causes inflammation and damage to various body tissues and organs.

27 Apr 2019

C-Path's PRO Consortium announces FDA qualification of new asthma clinical outcome assessment tools

Critical Path Institute's Patient-Reported Outcome Consortium announces U.S. Food and Drug Administration qualification of two new clinical outcome assessment tools: the Asthma Daytime Symptom Diary and the Asthma Nighttime Symptom Diary.

10 Apr 2019

Depression symptoms associated with death among patients with HIV infection

In a new study to investigate the relationship among depressive disorders or symptoms, HIV status and mortality, researchers report that symptoms of depression are moderately associated with death among Veterans with HIV but not among those without HIV infection.

2 Apr 2019

Researchers describe mathematical model as key to developing effective drugs for brain disorders

A collaboration between researchers from the UAB Institute of Neurosciences and the pharmaceutical company GlaxoSmithKline, published in March in Trends in Pharmacological Sciences, describes a mathematical model to quantify the activity of biased G-protein-coupled receptors.

28 Mar 2019