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What is the role of adenoviruses in human health?

With advances in molecular biology informing recent developments in vaccinology, gene therapy, and other fields of medicine, human adenoviruses (HAdVs) have been of primary importance in medical research. A recent review looks at the promises of HAdVs, their potential dangers, and future challenges.

9 Nov 2022

Supreme Court to hear nursing home case that could affect millions

When Susie Talevski sued the agency that managed her elderly father's care before he died, she hoped to get justice for her family.

7 Nov 2022

Researchers use brain organoids to show how SARS-CoV-2 virus infects cortical neurons

Using human brain organoids, an international team of researchers, led by scientists at University of California San Diego School of Medicine and Sanford Consortium, has shown how the SARS-CoV-2 virus that causes COVID-19 infects cortical neurons and specifically destroys their synapses -; the connections between brain cells that allow them to communicate with each other.

3 Nov 2022

Study determines the diagnostic utility of liver stiffness measurement

Even after chronic hepatitis C has been cured, portal hypertension remains the major factor driving the development of complications in advanced liver disease. In cooperation with researchers from Spain, a research team led by Georg Semmler and Mattias Mandorfer from the Division of Gastroenterology and Hepatology at MedUni Vienna's Department of Medicine III showed that the non-invasive tests explored in their earlier studies accurately estimate the probability of sequelae.

3 Nov 2022

What is the role of cyclophilin-A in alleviating SARS-CoV-2 infections?

A new study aimed to analyze the molecular interactions between the hCypA protein and the SARS-CoV-2 variants to determine the impact of variants on the blocking and binding potential of the hCypA–S protein complex with the ACE2 receptor.

2 Nov 2022

Immune checkpoint therapy may be beneficial in certain cases of severe COVID-19

An article published in Science Advances suggests that a type of cancer treatment known as immune checkpoint blockade may be beneficial in certain cases of severe COVID-19.

27 Oct 2022

Third dose of COVID-19 mRNA vaccine offers cirrhosis patients strong protection against the virus

Cirrhosis of the liver is associated with decreased responsiveness to many vaccines, including those that protect against COVID-19.

27 Oct 2022

Did COVID-19 mitigation measures in the United Kingdom impact the transmission of other infectious diseases?

Researchers explored the impact of the coronavirus disease 2019 (COVID-19) pandemic-associated non-pharmaceutical prevention measures on the transmission of 22 infectious diseases in England.

25 Oct 2022

Large genome-wide association study on nonalcoholic fatty liver disease

Scientists at deCODE genetics in Iceland have discovered rare, protective loss-of-function variants that point to potential drug targets for nonalcoholic fatty liver disease (NAFLD).

24 Oct 2022

Three-dose regimen of HEPLISAV-B vaccine fully protects people living with HIV, data shows

The AIDS Clinical Trials Group (ACTG), the world's largest HIV research network whose focus has expanded to include evaluating outpatient treatment for COVID-19, today presented a session demonstrating that a three-dose regimen of the HEPLISAV-B vaccine fully protected people living with HIV at IDWeek 2022, taking place in Washington D.C. from October 19-22, 2022.

20 Oct 2022

Scientists map structure of the hepatitis C virus E1E2 glycoprotein complex

A team led by scientists at Scripps Research and the University of Amsterdam has achieved an important goal in virology: mapping, at high resolution, critical proteins that stud the surface of the Hepatitis C virus (HCV) and enable it to enter host cells.

20 Oct 2022

Three-dose course of the hepatitis B vaccine fully protects adults living with HIV

A three-dose course of the hepatitis B vaccine HEPLISAV-B fully protected adults living with HIV who had never been vaccinated against or infected with the hepatitis B virus (HBV), according to study findings presented today at the IDWeek conference in Washington, D.C.

20 Oct 2022

Scientists develop a pseudovirus system to deep mutational scan the full SARS-CoV-2 spike

A pseudovirus system based on deep mutational scanning determines how SARS-CoV-2 mutations can affect its ability to escape neutralization.

18 Oct 2022

Recent innovations in infectious disease diagnostics

A recent Clinical Biochemistry editorial reports the latest innovations in the field of infectious disease diagnostics.

17 Oct 2022

Researchers explore single-cell sequencing technologies to understand molecular mechanisms of autoimmune diseases

A new review discussed the applications of single-cell ribonucleic acid sequencing (scRNA-seq) in understanding autoimmune disorders.

17 Oct 2022

Inhalation therapeutics against COVID-19

A recent study published in the Pulmonary Pharmacology & Therapeutics journal described different inhalation therapeutic agents for treating respiratory viral infections like coronavirus disease 2019 (COVID-19).

17 Oct 2022

A rare case of Hashimoto encephalopathy after COVID vaccination

In a recent ‘Letter to the Editor’ published in the English edition of the journal Neurologandiacute, researchers reported the rare occurrence of Hashimoto encephalopathy in a recipient of the (COVID-19) vaccine Spikevax. Spikevax, research name mRNA-1273, is a COVID-19 vaccine based on the messenger ribonucleic acid (mRNA) technology.

16 Oct 2022