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Study reveals molecular mechanisms underlying expansive arterial remodeling

Expansive arterial remodeling comprises a genetically programmed biological response designed to restore homeostatic levels of arterial wall stress after an increase in vessel flow load occurs.

25 Aug 2018

New biosensor tracks oxygen levels in real time in 'organ-on-a-chip' systems

A new biosensor allows researchers to track oxygen levels in real time in "organ-on-a-chip" systems, making it possible to ensure that such systems more closely mimic the function of real organs.

21 Aug 2018

RNA and DNA sequencing platform matches broader swath of drugs to late-stage cancer patients

A comprehensive RNA and DNA sequencing platform benefits late-stage and drug-resistant multiple myeloma patients by determining which drugs would work best for them, according to results from a clinical trial published in JCO Precision Oncology in August.

9 Aug 2018

Scientists create predictive model for neuroblastoma that incorporates early developmental signals

Neuroblastoma, a rare childhood cancer of the sympathetic nervous system, is particularly deadly because it is difficult to detect and thus generally advanced before treatment begins.

9 Jul 2018

AI could improve clinical diagnosis and treatment of prostate cancer

Researchers in Sweden have shown how data-driven AI could contribute to a better understanding of how prostate cancer develops, and even improve clinical diagnosis and treatment of the disease.

26 Jun 2018

Studying The Effects of Microgravity on Muscle Mass

Studying the effects of gravity on muscle cells can give us an insight into muscle wastage diseases, and potentially guide the development of new therapies. Professor Louis Yuge discusses his research and the cellular changes that occur in response to microgravity.

25 Jun 2018

Researchers discover medulloblastoma subtype that responds to less aggressive therapy

The youngest patients with the brain tumor medulloblastoma are among the most challenging because their rapidly developing brains limit treatment options.

17 May 2018

New findings point to potential therapeutic avenues for leukemia

Scientists have known for decades that the Hox family of transcription factors are key regulators in the formation of blood cells and the development of leukemia.

9 May 2018

Study shows new approach to improve survival rates for patients with stage IV Wilms tumors

A new study showing significantly improved survival rates for patients with stage IV Wilms tumors with lung metastases was recently published in the Journal of Clinical Oncology.

26 Apr 2018

Bio-Techne expands automation capabilities of popular RNAscope ISH technology

Bio-Techne has expanded the automation capabilities of its popular Advanced Cell Diagnostics -branded RNAscope in situ hybridization technology with the launch of several new and updated assays.

From Bio-Techne 18 Apr 2018

Study shows potential of web-based intervention to achieve weight loss in patients with NAFLD

Patients with non-alcoholic fatty liver disease who participated in a web-based lifestyle modification intervention achieved similar levels of weight loss and more rapid normalization of their liver enzymes than patients who participated in an intensive, group-based program.

13 Apr 2018

Researchers propose alternative treatment to target lymphoma signaling at its root

Non-Hodgkin lymphomas are cancers that affect white blood cells of the immune system called B-lymphocytes or B cells. Like cells in all cancers, the B cells begin to grow out of control, creating tumors in the lymph nodes, spleen or other tissues. In 2010 alone, it was estimated that non-Hodgkin lymphomas caused 210,000 deaths worldwide.

22 Mar 2018

Artificial sweetener sucralose worsens gut inflammation in mice with Crohn's disease

In a study that has implications for humans with inflammatory diseases, researchers from Case Western Reserve University School of Medicine and colleagues have found that, given over a six-week period, the artificial sweetener sucralose, known by the brand name Splenda, worsens gut inflammation in mice with Crohn's-like disease, but had no substantive effect on those without the condition.

15 Mar 2018

Researchers achieve 80% reduction in liver metastasis by restricting growth of blood vessels

The International Journal of Cancer has just published the results of an experimental therapy tested on mice. The research, led by the Signaling Lab research group of the UPV/EHU's Faculty of Medicine and Pharmacy and the Department of Pharmacology, Pharmacy and Pharmaceutical Technology of the University of Santiago de Compostela, achieved an 80% reduction in liver metastasis brought about by colon cancer.

14 Mar 2018

Gastrointestinal hormone offers possible new treatment for NAFLD and NASH patients

Through a randomized, double-blind, placebo-controlled phase II clinical trial, researchers at University of California San Diego School of Medicine report that small doses of NGM282, a non-tumorigenic variant of an endocrine gastrointestinal hormone, can significantly and rapidly decrease liver fat content in patients with non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH).

9 Mar 2018

New staining method helps analyze 3D tissue samples using Nano-CT system

To date, examining patient tissue samples has meant cutting them into thin slices for histological analysis. This might now be set to change - thanks to a new staining method devised by an interdisciplinary team from the Technical University of Munich.

23 Feb 2018

Scientists gain better understanding of how the intestine repairs itself after injury

Researchers at Baylor College of Medicine, Johns Hopkins University School of Medicine and the University of California, San Francisco have gained new insights into how the small intestine, one of the fastest renewing tissues in the human body, repairs itself after injury caused by intestinal rotavirus infection.

30 Jan 2018

Researchers reveal pathological mechanisms in congenital myotonic dystrophy

Myotonic dystrophy (DM) is the most common form of genetic muscular dystrophy that begins in adulthood. DM is characterized by progressive muscle wasting and weakness. People with this disorder often have prolonged muscle contractions (myotonic) and are not able to relax certain muscles after use.

12 Dec 2017

Researchers explore new method of destroying tumor cells

Researchers from Lomonosov MSU Faculty of Biology have studied the stages of entosis, a process of cell death when one cell invades the other and gets digested inside of it. Entosis could become a new method of destroying cancer cells.

27 Nov 2017

Study finds specific tumor environment that stimulates cancer cells to metastasize

A new study, conducted by a team of researchers from the University of California, San Diego, has identified how the environment surrounding a tumor can stimulate metastatic behavior in the individual cancer cells. Researchers found that the tumor cells activate a particular set of genes and begin to form blood vessel-like structures when they are confined in a densely packed environment.

22 Nov 2017