Cell Death News and Research

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Scientists elucidate why exercise slows progression of Parkinson's disease

While vigorous exercise on a treadmill has been shown to slow the progression of Parkinson's disease in patients, the molecular reasons behind it have remained a mystery.

22 Dec 2017

Study findings could lead to less expensive and more effective cancer treatments

The latest generation of cancer treatments spring from the discovery that the human immune system is able to beat the disease. Like Dorothy in "The Wizard of Oz," what research teams around the world have spent decades searching for was right in their own backyard all along.

20 Dec 2017

Stem cells remain healthy following low-dose X-ray exposure, say biophysicists

Biophysicists have shown that following low-dose exposure to X-rays (at 80 milligrays), stem cells remain healthy, proliferate, and do not accumulate DNA damage to be passed on to their progeny. The paper was published in the journal Aging.

20 Dec 2017

Two studies show how cells adapt to stressors by reprogramming internal signaling networks

In a pair of publications, researchers have shown how cells adapt to stressors--like water loss--by reprogramming their internal signaling networks.

20 Dec 2017

UCLA researchers reveal reversibility of Friedreich's ataxia in mouse models

In children and adults with Friedreich's ataxia, an inherited disease that causes damage to the nervous system, a loss of coordination typically progresses to muscle weakness and can involve vision, diabetes, and other problems over the course of several years.

20 Dec 2017

New scalp device delivering electric fields improves survival in patients with glioblastoma

A device attached to a patient's scalp that delivers a continuous dose of low-intensity electric fields improves survival and slows the growth of a deadly brain tumor, according to a new clinical trial led by a Northwestern Medicine scientist and published Dec. 19 in the journal JAMA.

19 Dec 2017

Study finds combination therapy as effective strategy to treat ovarian cancers

Researchers at The Wistar Institute have found that combining PARP inhibitors, recently approved for the treatment of BRCA-mutant ovarian cancer, with another small molecule inhibitor was effective to treat ovarian cancers without BRCA1 and BRCA2 gene mutations.

19 Dec 2017

Researchers use genomics to advance understanding of Parkinson´s disease

It is widely known that genomics has already begun to influence medicine and that bioinformatics holds the key for developing new medical approaches, but how does medical genomics really work?

19 Dec 2017

Nano-encapsulation of bilirubin could enhance survival rates of pancreatic islet cells

By encapsulating bilirubin within tiny nanoparticles, researchers from North Carolina State University and the Ohio State University have improved the survival rates of pancreatic islet cells in vitro in a low-oxygen environment.

18 Dec 2017

Spatial deconvolution of marker expression in whole heart subjected to ischemia-reperfusion

When a coronary artery is obstructed by atheroma, blood flow is depressed or even arrested. This causes hypoxia of cardiac cells associated with the deprivation of nutrients. In clinic, the first objective is to restore blood flow. However, this is associated with a burst in oxidation of cellular proteins and lipids. This oxidation enhances cell death and participates to the so-called reperfusion injury.

From Logos Biosystems 18 Dec 2017

Researchers take step toward using man-made nanoscale compounds to fight cancer

Researchers in Sweden have succeeded in taking the next step toward using man-made nanoscale compounds in the fight against cancer.

13 Dec 2017

Caris Life Sciences reveals identification of new mechanism of action to treat NHL

Caris Life Sciences, a leading innovator in molecular science focused on fulfilling the promise of precision medicine, today announced a data presentation, at the 59th American Society of Hematology Annual Meeting & Exposition in Atlanta, demonstrating the identification of a new mechanism of action to treat non-Hodgkin lymphoma (NHL).

13 Dec 2017

Newly discovered molecular chaperones may soon be part of therapies for Huntington's disease

Huntington's disease is a neurodegenerative disease. It is always fatal. The disease is caused by a defect in the Huntingtin gene. To this day, no therapy will put a stop to the insidious disintegration of brain cells.

12 Dec 2017

Study: Combination targeted therapy has high response rates in AML patients

Initial findings from a multi-national open-label phase Ib study of inhibitory drug therapy for relapsed or refractory acute myeloid leukemia (AML) have demonstrated a complete response in up to 50 percent patients say researchers at The University of Texas MD Anderson Cancer Center.

11 Dec 2017

Death receptors in the blood can help measure risk of cardiovascular diseases, type 2 diabetes

Researchers at Lund University in Sweden have found that the presence of death receptors in the blood can be used to directly measure the risk of developing cardiovascular diseases and type 2 diabetes.

11 Dec 2017

Simple molecular test may help predict presence of high-grade pancreatic cancers

A report in The Journal of Molecular Diagnostics, describes a new simple molecular test to detect chromosomal abnormalities -- biomarkers known as telomere fusions--in pancreatic tumor specimens and pancreatic cyst fluids.

8 Dec 2017

MIT researchers discover new way to make bacteria vulnerable to existing antibiotics

MIT researchers have discovered a way to make bacteria more vulnerable to a class of antibiotics known as quinolones, which include ciprofloxacin and are often used to treat infections such as Escherichia coli and Staphylococcus aureus.

8 Dec 2017

Brazilian researchers identify genes linked to melanoma progression

When researchers at the University of São Paulo in Brazil treated human melanoma cell lines with a synthetic compound similar to curcumin, one of the pigments that give turmeric its orange color, they identified genes with altered expression in potentially invasive tumors and malignant cells resistant to chemotherapy.

6 Dec 2017

New small-molecule drug restores brain function, memory in mouse model of Alzheimer's disease

An international team of researchers has shown that a new small-molecule drug can restore brain function and memory in a mouse model of Alzheimer's disease.

5 Dec 2017

Lithium chloride prevents neurological damage tied to fetal alcohol syndrome, mice study shows

A single dose of lithium chloride, a drug used to treat bipolar disease and aggression, blocks the sleep disturbances, memory loss, and learning problems tied to fetal alcohol syndrome, new experiments in mice show.

5 Dec 2017

Cell Death News and Research

Scientists elucidate why exercise slows progression of Parkinson's disease

Study findings could lead to less expensive and more effective cancer treatments

Stem cells remain healthy following low-dose X-ray exposure, say biophysicists

Two studies show how cells adapt to stressors by reprogramming internal signaling networks

UCLA researchers reveal reversibility of Friedreich's ataxia in mouse models

New scalp device delivering electric fields improves survival in patients with glioblastoma

Study finds combination therapy as effective strategy to treat ovarian cancers

Researchers use genomics to advance understanding of Parkinson´s disease

Nano-encapsulation of bilirubin could enhance survival rates of pancreatic islet cells

Spatial deconvolution of marker expression in whole heart subjected to ischemia-reperfusion

Researchers take step toward using man-made nanoscale compounds to fight cancer

Caris Life Sciences reveals identification of new mechanism of action to treat NHL

Newly discovered molecular chaperones may soon be part of therapies for Huntington's disease

Study: Combination targeted therapy has high response rates in AML patients

Death receptors in the blood can help measure risk of cardiovascular diseases, type 2 diabetes

Simple molecular test may help predict presence of high-grade pancreatic cancers

MIT researchers discover new way to make bacteria vulnerable to existing antibiotics

Brazilian researchers identify genes linked to melanoma progression

New small-molecule drug restores brain function, memory in mouse model of Alzheimer's disease

Lithium chloride prevents neurological damage tied to fetal alcohol syndrome, mice study shows

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