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Neuropathic pain study uncovers pathophysiological mechanism and promising therapeutic target

Neuropathic pain - abnormal hypersensitivity to stimuli - is associated with impaired quality of life and is often poorly managed. Estimates suggest that 3 percent to 17 percent of adults suffer from neuropathic pain, including a quarter of people with diabetes and a third of people with HIV.

5 May 2023

Exploring the World of RNA Chemistry

In this interview conducted at Pittcon 2023 in Philadelphia, Pennsylvania, we spoke to Philip Bevilacqua from Pennsylvania State University about the world of RNA chemistry.

From Pittcon 5 May 2023

Researchers identify a potential safer route to pain relief

Strategies to treat pain without triggering dangerous side effects such as euphoria and addiction have proven elusive.

4 May 2023

Study pinpoints how gut microbes boost the body's response to cancer immunotherapy

Cancer immunotherapy has transformed the treatment of many types of cancer. Yet, for reasons that remain poorly understood, not all patients get the same benefit from these powerful therapies.

4 May 2023

Revving up COVID mRNA vaccines: Algorithm generates 128-fold increase in antibodies

Research paper proposes a new method for predicting highly expressed genes based on codon usage bias and minimum free energy of mRNA secondary structures. The method involves constructing a stochastic grammar that generates sequences with high CAI and low MFE, and testing it on two mRNA vaccines.

3 May 2023

New technology can deliver gene therapy directly to the lung

Scientists at UMass Chan Medical School have developed a technology to deliver gene therapy directly to lung tissue through intranasal administration, a development that could potentially create a new class of treatments for lung disease.

2 May 2023

How does air pollution impact perinatal mental health?

Researchers show strong associations between air pollution and poor perinatal mental health.

2 May 2023

Unraveling Nature's Complexity with Molecular Imaging

In this interview conducted at Pittcon 2023 in Philadelphia, Pennsylvania, we spoke to Ron Heeran, a speaker at the 2023 James L. Waters Symposium.

From Pittcon 1 May 2023

Structure of protein methyltransferase from the monkeypox virus deciphered

Scientists from the Institute of Organic Chemistry and Biochemistry in Prague have deciphered the structure of the protein methyltransferase from the monkeypox virus

30 Apr 2023

Cryogenic electron microscopy helps visualize structural details of gene regulation process

LMU researchers show detailed displacement process of TBP transcription factor from DNA by Mot1 enzyme.

28 Apr 2023

New strategy for identifying small molecules offers a promising path for discovering targeted drugs

Scripps Research scientists have developed a new strategy for identifying small molecules that can change the function of proteins, offering a promising path for discovering targeted drugs.

27 Apr 2023

Vein-on-a-chip model can help understand the mechanisms of blood clot formation

Blood clot researchers could benefit from a new device that mimics a human vein, replacing the need for animals for some studies.

27 Apr 2023

Researchers identify a druggable copper-signaling pathway that drives inflammation

Inflammation is a complex biological process that can eradicate pathogens and promotes repair of damaged tissues.

27 Apr 2023

Research develops unique delivery system to treat osteosarcoma

New research has identified a potential therapeutic target and developed a unique delivery system to treat osteosarcoma, a bone cancer that primarily affects children and adolescents.

27 Apr 2023

Mechanism to protect the liver from destruction in case of obesity revealed

Scientists from the Immanuel Kant Baltic Federal University found out that blocking of receptor gp130 on the surface of liver cells helps to protect this organ from destruction in case of obesity.

27 Apr 2023

Researchers unravel processes that direct the development of astrocyte structure

Researchers at Baylor College of Medicine have unraveled the processes that give astrocytes, the most abundant glial cell in the brain, their special bushy shape, which is fundamental for brain function.

26 Apr 2023

Groundbreaking discovery could pave the way for safer and more effective blood thinners

Safer and more effective blood thinners could be on the way following a groundbreaking discovery by researchers at UBC and the University of Michigan, published today in Nature Communications.

26 Apr 2023

Neutrophils found to play a key role in fibromyalgia pain

Targeting neutrophil activity and interactions with sensory neurons may be a potential approach for treating fibromyalgia pain.

25 Apr 2023

Previously unknown mechanisms may lead to new approaches to fight viral infections

Viruses like influenza A and Ebola invade human cells in a number of steps. In an interdisciplinary approach, research teams from Heidelberg University and Heidelberg University Hospital investigated the final stages of viral penetration using electron tomography and computer simulations.

25 Apr 2023

New approach to CAR T-cell therapy shows promise against small cell lung cancer in preclinical study

A new approach to chimeric antigen receptor T-cell (CAR T) therapy has shown great promise against small cell lung cancer (SCLC) in a preclinical study.

25 Apr 2023

Molecule News and Research

Neuropathic pain study uncovers pathophysiological mechanism and promising therapeutic target

Exploring the World of RNA Chemistry

Researchers identify a potential safer route to pain relief

Study pinpoints how gut microbes boost the body's response to cancer immunotherapy

Revving up COVID mRNA vaccines: Algorithm generates 128-fold increase in antibodies

New technology can deliver gene therapy directly to the lung

How does air pollution impact perinatal mental health?

Unraveling Nature's Complexity with Molecular Imaging

Structure of protein methyltransferase from the monkeypox virus deciphered

Cryogenic electron microscopy helps visualize structural details of gene regulation process

New strategy for identifying small molecules offers a promising path for discovering targeted drugs

Vein-on-a-chip model can help understand the mechanisms of blood clot formation

Researchers identify a druggable copper-signaling pathway that drives inflammation

Research develops unique delivery system to treat osteosarcoma

Mechanism to protect the liver from destruction in case of obesity revealed

Researchers unravel processes that direct the development of astrocyte structure

Groundbreaking discovery could pave the way for safer and more effective blood thinners

Neutrophils found to play a key role in fibromyalgia pain

Previously unknown mechanisms may lead to new approaches to fight viral infections

New approach to CAR T-cell therapy shows promise against small cell lung cancer in preclinical study

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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