Pharmaceuticals News and Research

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Preventative HIV vaccines induce robust, comparable immune responses in humans and monkeys

More than three decades after the identification of the human immunodeficiency virus, scientists are still working to develop a preventative vaccine that could finally put an end to the epidemic for which there are nearly two million new infections each year.

9 Jul 2018

Machine-learning model automates design of new molecules to accelerate drug development

Designing new molecules for pharmaceuticals is primarily a manual, time-consuming process that's prone to error. But MIT researchers have now taken a step toward fully automating the design process, which could drastically speed things up -- and produce better results.

9 Jul 2018

Podcast: KHN’s ‘What the Health?’ Whither work requirements?

A federal District Court judge in Washington, D.C., has — for now — blocked Kentucky's proposal to add a work requirement for much of its adult Medicaid population.

6 Jul 2018

Research opens clever new way to attack cancer stem cells

Researchers are the University of Michigan Rogel Cancer are unraveling a crucial thread that explains why cancer so often becomes resistant to treatment.

3 Jul 2018

PMDA approves use of LYNPARZA in patients with BRCA-mutated breast cancer

AstraZeneca and Merck, known as MSD outside the United States and Canada, today announced that Japan's Pharmaceuticals and Medical Devices Agency has approved LYNPARZA tablets for use in patients with unresectable or recurrent BRCA-mutated, human epidermal growth factor receptor 2 -negative breast cancer who have received prior chemotherapy.

2 Jul 2018

New Rekovelle analysis shows AMH is robust predictor of ovarian response to fertility treatment

Ferring Pharmaceuticals announced today a new analysis of data from the Phase 3 ESTHER-1 trial showing that natural variations in anti-Müllerian hormone levels during and between a woman's menstrual cycle have no clinically relevant impact on ovarian response when using AMH to dose Rekovelle for ovarian stimulation.

2 Jul 2018

Ocular Therapeutix resubmits NDA for DEXTENZA

Ocular Therapeutix™, Inc., a biopharmaceutical company focused on the formulation, development, and commercialization of innovative therapies for diseases and conditions of the eye, has announced the resubmission of the Company's New Drug Application to the U.S. Food and Drug Administration for its lead product candidate DEXTENZA™ 0.4mg, for the treatment of ocular pain following ophthalmic surgery.

30 Jun 2018

Atlantic Health System starts enrolling patients in four pancreatic cancer clinical trials

Atlantic Health System is now enrolling patients in four pancreatic cancer clinical trials. Angela Alistar, MD, a nationally known expert on pancreatic cancer, is serving as national Principal Investigator on the first trial and as local PI on three other trials.

30 Jun 2018

New approach paves way for electrochemical synthesis of opium alkaloids

Researchers at Johannes Gutenberg University Mainz have mastered a nearly 50-year-old challenge of electrosynthetic chemistry, namely the electrochemical synthesis of thebaine.

30 Jun 2018

Top policy expert’s ties to giant drugmaker often go unstated

When Dr. Mark McClellan sat for an in-depth 30-minute question-and-answer session at an April health policy forum, the audience was filled with top researchers, advocates and Capitol Hill staffers eager to hear what insight the former head of the Food and Drug Administration would dispense.

29 Jun 2018

Survey: Psoriasis patients may face a long journey to achieve goal of clear skin

Novartis announced today the publication of global Clear about Psoriasis survey data in the Journal of the European Academy of Dermatology and Venereology. The publication highlights that despite clear or almost clear skin being more achievable than ever before, patients may face a long journey to attain this reality.

From Novartis 29 Jun 2018

New heat stable version of Carbetocin to prevent hemorrhage after birth

The World Health Organization (WHO) has said that a new heat stable version of a drug Carbetocin can save lives of new mothers could “revolutionize” therapy. The results of the study looking at the effectiveness of the new version of the drug were published in the latest issue of the New England Journal of Medicine.

28 Jun 2018

FDA approves cannabis based drug for severe form of epilepsy

The U.S. Food and Drug Administration (FDA) on the 25th of June 2018 approved Epidiolex oral solution that is essentially cannabidiol or the active component of marijuana or cannabis. As of now the drug is approved for use in two rare forms of epilepsy - Lennox-Gastaut syndrome and Dravet syndrome. The approval comes for individuals over two years of age.

28 Jun 2018

AntiCancer's oral drug overcomes gemcitabine resistance in mouse models of human pancreatic cancer

Pancreatic cancer is lethal in about 95% of cases mostly due to failure of first-line therapy gemcitabine. AntiCancer Inc.'s oral methioninase (AC 00619), which is in late pre-clinical development as an anti-cancer as well as an anti-aging drug, has now been shown to overcome gemcitabine resistance in mouse models of human pancreatic cancer, including AntiCancer's patient-derived orthotopic xenograft mouse models.

25 Jun 2018

Study suggests proteinuria lowering as important target in managing pediatric CKD

In a study of children with chronic kidney disease, blood pressure medications reduced protein excretion in the urine, which was linked with a lower risk of disease progression.

22 Jun 2018

Chemists find new way to make enzymes do a non-natural reaction

Princeton chemists have found a way to make a naturally occurring enzyme take on a new, artificial role, which has significant implications for modern chemistry, including pharmaceutical production.

22 Jun 2018

Aquinnah Pharmaceuticals wins NINDS grant to advance novel therapies for ALS

Aquinnah Pharmaceuticals, leaders in stress granule biology, an exciting new target for the development of neurodegenerative therapeutics, announced today that it has been awarded $3.4 million from the National Institute of Neurological Disorders and Stroke in a competing grant to advance novel therapeutic drug candidates towards the clinic for treating patients with amyotrophic lateral sclerosis, also known as Lou Gehrig's disease.

21 Jun 2018

Pharmaceuticals News and Research

Preventative HIV vaccines induce robust, comparable immune responses in humans and monkeys

Machine-learning model automates design of new molecules to accelerate drug development

Podcast: KHN’s ‘What the Health?’ Whither work requirements?

Research opens clever new way to attack cancer stem cells

PMDA approves use of LYNPARZA in patients with BRCA-mutated breast cancer

New Rekovelle analysis shows AMH is robust predictor of ovarian response to fertility treatment

Ocular Therapeutix resubmits NDA for DEXTENZA

Atlantic Health System starts enrolling patients in four pancreatic cancer clinical trials

New approach paves way for electrochemical synthesis of opium alkaloids

Top policy expert’s ties to giant drugmaker often go unstated

Survey: Psoriasis patients may face a long journey to achieve goal of clear skin

New heat stable version of Carbetocin to prevent hemorrhage after birth

FDA approves cannabis based drug for severe form of epilepsy

AntiCancer's oral drug overcomes gemcitabine resistance in mouse models of human pancreatic cancer

Study suggests proteinuria lowering as important target in managing pediatric CKD

Chemists find new way to make enzymes do a non-natural reaction

Aquinnah Pharmaceuticals wins NINDS grant to advance novel therapies for ALS

Researchers employ nucleotide-based gene silencing to mitigate common ataxia

Malnutrition could have major health implications on patients' surgical outcomes, shows research

Researchers use droplet-sized 'miniecosystems' to test therapeutic potential of molecules

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