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Researchers identify potential ovarian cancer stem cells

Massachusetts General Hospital (MGH) researchers have identified potential ovarian cancer stem cells, which may be behind the difficulty of treating these tumors with standard chemotherapy.

21 Jul 2006

Doctors may be over-diagnosing melanoma in sun-damaged skin

A Mayo Clinic physician and colleagues have defined the normal number of melanocytes that are present in Caucasians' sun-exposed skin.

18 Jul 2006

New role discovered for breast cancer susceptibility gene BRCA1

A recently discovered facet of the breast cancer susceptibility gene BRCA1 reveals a mechanism linking mutation of BRCA1 to formation of large blood vessels needed to support cancer progression.

18 Jul 2006

An accurate model of p53 tumor suppressor protein bound to DNA for anti-cancer activity

More than half of human cancers involve mutations in the p53 tumor-suppressor gene, suggesting the critical role played by the normal p53 protein in defending against cancer.

18 Jul 2006

FDA approval for Gemzar for ovarian cancer

Eli Lilly and Company announced that the United States Food and Drug Administration (FDA) has approved Gemzar (gemcitabine HCl) for use in the treatment of women living with recurrent ovarian cancer.

18 Jul 2006

Herceptin-linked nanoparticles for targeted cancer therapy

Albumin nanoparticles have recently proven their mettle as anticancer agents with the 2005 approval of Abraxane to treat metastatic breast cancer.

17 Jul 2006

Self-illuminating quantum dots for in vivo imaging

Quantum dots have already proven themselves as powerful imaging probes that can enable researchers to track disease-related molecules inside cells and even within the body.

17 Jul 2006

Researchers find cause of frontotemporal dementia

Frontotemporal Dementia (FTD) is the second major form of dementia.

17 Jul 2006

Mechanics of atherosclerosis

Atherosclerotic narrowing and hardening of coronary arteries typically appear first at vessel branches, and a study in the October issue of Cellular Signalling reports that the type of mechanical stretching found at those branches activates a cellular protein known to damage cells.

12 Jul 2006

Female smokers have higher risk of lung cancer than male smokers but lower death rates

Women who smoke appear to be more susceptible to lung cancer than men who smoke, though women smokers have a lower rate of lung cancer-related death, according to a study in the July 12 issue of Journal of the American Medical Association.

12 Jul 2006

3D model reveals secrets of metastasis

A cancer cell breaks away from a primary tumor and settles in a new location, where it once again divides.

12 Jul 2006

Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells

Various types of carbon-based nanomaterials, such as buckyballs and nanotubes, have shown promise as drug delivery tools and imaging agents, but reports of toxicity associated with some of these materials have raised questions about their ultimate utility in clinical oncology.

10 Jul 2006

Nanoscale metal-organic frameworks as potential multimodal contrast enhancing agents

By combining the properties of inorganic and organic molecules in one material, researchers at the Carolina Center of Cancer Nanotechnology Excellence (CCNE) have developed a new class of nanomaterials that can be used to create multifunctional nanoparticles.

10 Jul 2006

Imaging pancreatic cancer with a peptide-nanoparticle conjugate targeted to normal pancreas

Most attempts to develop imaging agents that can better distinguish tumors from healthy tissue focus on finding molecules that are more abundant on malignant cells than on normal cells and using those as cellular targets.

10 Jul 2006

Combination of anastrozole and a synthetic hormone called goserelin may slow male breast cancer growth

Medical oncologists across the nation want to know whether a certain drug combination can slow the progression of male breast cancer, a rare disease that often goes undiagnosed until it's in an advanced stage.

10 Jul 2006

Parameters associated with patient outcomes in lymph node positive prostate cancer

Dr. Hofer and colleagues report in the June issue of Urology that lymphovascular invasion (LVI) and the nuclear grade of the primary prostate tumor are independent predictors of PSA recurrence in men with lymph node positive CaP.

3 Jul 2006

New polymer-lipid hybrid nanoparticle

A novel combination of lipids, a negatively charged polymer, and the anticancer drug doxorubicin has yielded a new nanoparticle that can kill breast cancer cells that are normally resistant to this drug.

3 Jul 2006

Thermosensitive pluronic micelles stabilized by shell cross-linking with gold nanoparticles

Many types of nanoparticles can cross the cell membrane and deliver their therapeutic payload into tumor cells.

3 Jul 2006

Buckyballs deliver multiple drugs simultaneously to tumors

Combining a monoclonal antibody known to target melanoma tumors with multiple C60 buckyballs, researchers at Rice University and the University of Texas M. D. Anderson Cancer Center have developed a new way to deliver multiple drugs simultaneously to tumors.

3 Jul 2006

Multiple cancer biomarkers detected simultaneously

Polymerase chain reaction (PCR) technology revolutionized diagnostic medicine and basic research through its ability to amplify and detect minute amounts of specific DNA sequences.

3 Jul 2006

Tumor News and Research

Researchers identify potential ovarian cancer stem cells

Doctors may be over-diagnosing melanoma in sun-damaged skin

New role discovered for breast cancer susceptibility gene BRCA1

An accurate model of p53 tumor suppressor protein bound to DNA for anti-cancer activity

FDA approval for Gemzar for ovarian cancer

Herceptin-linked nanoparticles for targeted cancer therapy

Self-illuminating quantum dots for in vivo imaging

Researchers find cause of frontotemporal dementia

Mechanics of atherosclerosis

Female smokers have higher risk of lung cancer than male smokers but lower death rates

3D model reveals secrets of metastasis

Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells

Nanoscale metal-organic frameworks as potential multimodal contrast enhancing agents

Imaging pancreatic cancer with a peptide-nanoparticle conjugate targeted to normal pancreas

Combination of anastrozole and a synthetic hormone called goserelin may slow male breast cancer growth

Parameters associated with patient outcomes in lymph node positive prostate cancer

New polymer-lipid hybrid nanoparticle

Thermosensitive pluronic micelles stabilized by shell cross-linking with gold nanoparticles

Buckyballs deliver multiple drugs simultaneously to tumors

Multiple cancer biomarkers detected simultaneously

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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