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Scientists unravel secrets of mechanism that snips our genes

Certain diseases such as cystic fibrosis and muscular dystrophy are linked to genetic mutations that damage the important biological process of rearranging gene sequences in pre-messenger RNA, a procedure called RNA splicing.

27 Sep 2013

Study indicates that RNA translation is dictated by translational hotspots

Protein synthesis in the extensions of nerve cells, called dendrites, underlies long-term memory formation in the brain, among other functions. "Thousands of messenger RNAs reside in dendrites, yet the dynamics of how multiple dendrite messenger RNAs translate into their final proteins remain elusive," says James Eberwine, PhD, professor of Pharmacology, Perelman School of Medicine at the University of Pennsylvania, and co-director of the Penn Genome Frontiers Institute.

27 Sep 2013

Researchers develop brown fat detection method to combat obesity

When it comes to fat, you want the brown type and not so much of the white variety because brown fat burns energy to keep you warm and metabolically active, while white fat stores excess energy around your waist, causing health problems. Researchers at The University of Texas Health Science Center at Houston Medical School are studying brown fat with a goal of fighting obesity.

19 Sep 2013

New optical imaging tool enables scientists to observe tumors and uncover inner workings

Scientists seeking new ways to fight cancer often try to understand the subtle, often invisible, changes to DNA, proteins, cells, and tissue that alter the body's normal biology and cause disease.

18 Sep 2013

New prototype technique improves diagnosis of cancer tissue during operation

Tissue-conserving cancer surgery is a highly skilled procedure which involves time-consuming tissue preparation to detect the margins of cancerous tissue. The goal is to remove as much of the tumour as possible while sparing healthy tissue.

18 Sep 2013

Functional brain mapping and high speed physiology multiphoton system from Olympus

The Olympus FluoView® FVMPE-RS, a dedicated multiphoton microscope system, enables high-precision, ultra-fast scanning and stimulation, allowing researchers to see deep within specimens, take measurements at the highest speeds, and capture images even when working under the most demanding conditions.

From Evident Corporation - Life Sciences 17 Sep 2013

Overexpression of cytoglobin gene inhibits hypoxic injury to neuroblastoma cells

Cytoglobin is a temporary oxygen reservoir, which might provide a minimal, but continuous supply of intracellular oxygen during ischemic and anoxic conditions.

17 Sep 2013

LifeSensors receives U.S. patent for development of novel DUB substrates

LifeSensors, Inc., a biotech company developing cutting-edge technologies for studying the ubiquitin pathway, has been awarded a U.S. patent for the development of novel, fluorescent di- and poly-ubiquitin deubiquitinase substrates (US 8,518,660).

16 Sep 2013

Prairie Technologies acquired by Bruker

Bruker Corporation today announced that it has acquired Prairie Technologies, Inc. (Prairie), a provider of life science fluorescence microscopy products. The acquisition strengthens Bruker’s position in life science markets, adding to the Bruker Nano Surfaces Division’s existing life science atomic force microscopy (Bio-AFM) systems.

From Bruker Nano Surfaces and Metrology 13 Sep 2013

Current criteria for ALK positive lung cancer needs to be redefined

A University of Colorado Cancer Center study published today in the journal Cancer shows that the current criteria used to match lung cancers with the drug crizotinib may miss some patients who could benefit from the drug. The findings suggest that doctors should look closer at borderline or atypical ALK-negative cases, and could widen the population of lung cancer patients offered treatment with crizotinib or other ALK-inhibitor drugs.

12 Sep 2013

BioTek's Cytation3 Cell Imaging Multi-Mode Reader recognized by SelectScience

For the second year in a row, BioTek Instruments was announced as winner of the SelectScience "Scientists' Choice Award for Best Drug Discovery Product". The award was given for BioTek's new Cytation3 Cell Imaging Multi-Mode Reader, and was announced at ELRIG Drug Discovery in Manchester, UK.

12 Sep 2013

Scientists reveal how organic mercury can interfere with vision

More than one billion people worldwide rely on fish as an important source of animal protein, states the United Nations Food and Agriculture Organization. And while fish provide slightly over 7 per cent of animal protein in North America, in Asia they represent about 23 per cent of consumption.

12 Sep 2013

Researchers develop new imaging technique to study function of entire nervous systems

A major aim of today's neuroscience is to understand how an organism's nervous system processes sensory input and generates behavior. To achieve this goal, scientists must obtain detailed maps of how the nerve cells are wired up in the brain, as well as information on how these networks interact in real time.

10 Sep 2013

UCSF scientists identify new way to manipulate immune system from autoimmune diseases

Scientists from UC San Francisco have identified a new way to manipulate the immune system that may keep it from attacking the body-s own molecules in autoimmune diseases such as type 1 diabetes, rheumatoid arthritis and multiple sclerosis.

10 Sep 2013

Assay aids ALK fusion detection in lung adenonocarcinoma

A fully automated immunochemistry assay is highly sensitive and specific for detecting anaplastic lymphoma kinase fusion in primary lung adenocarcinomas, Chinese researchers report.

6 Sep 2013

Scientists develop robotic systems for image-guided removal of hard-to-reach brain tumors

NIBIB-funded scientists and engineers are teaming up with neurosurgeons to develop technologies that enable less invasive, image-guided removal of hard-to-reach brain tumors.

6 Sep 2013

Researchers develop method for purifying cardiac muscle cells using molecular beacons

Pure cardiac muscle cells, ready to transplant into a patient affected by heart disease. That's a goal for many cardiology researchers working with stem cells. Having a pure population of cardiac muscle cells is essential for avoiding tumor formation after transplantation, but has been technically challenging.

6 Sep 2013

Research findings raise hope for new heart therapies

Many people who survive a heart attack find themselves back in the hospital with a failing heart just years later. And the outcome often is unfavorable, owing to limited treatment options. But scientists at Temple University School of Medicine's Cardiovascular Research Center recently found hope in an unlikely source - stem cells in cortical, or compact, bone.

5 Sep 2013

Study identifies new tool to accurately analyze mtDNA deletions associated with diseases, aging

A study published today in Aging Cell identifies a new tool to accurately analyze extremely rare mitochondrial DNA deletions associated with a range of diseases and disorders as well as aging. This approach, which relies on Droplet Digital PCR (ddPCR-) technology, will help researchers explore mtDNA deletions as potential disease biomarkers.

4 Sep 2013

Researchers identify novel mechanism that particular superbug uses to fend off antibiotic

Investigators working to stem the spread of antibiotic-resistant bacteria have taken a major step in their efforts to develop new treatments.

29 Aug 2013

Fluorescence News and Research

Scientists unravel secrets of mechanism that snips our genes

Study indicates that RNA translation is dictated by translational hotspots

Researchers develop brown fat detection method to combat obesity

New optical imaging tool enables scientists to observe tumors and uncover inner workings

New prototype technique improves diagnosis of cancer tissue during operation

Functional brain mapping and high speed physiology multiphoton system from Olympus

Overexpression of cytoglobin gene inhibits hypoxic injury to neuroblastoma cells

LifeSensors receives U.S. patent for development of novel DUB substrates

Prairie Technologies acquired by Bruker

Current criteria for ALK positive lung cancer needs to be redefined

BioTek's Cytation3 Cell Imaging Multi-Mode Reader recognized by SelectScience

Scientists reveal how organic mercury can interfere with vision

Researchers develop new imaging technique to study function of entire nervous systems

UCSF scientists identify new way to manipulate immune system from autoimmune diseases

Assay aids ALK fusion detection in lung adenonocarcinoma

Scientists develop robotic systems for image-guided removal of hard-to-reach brain tumors

Researchers develop method for purifying cardiac muscle cells using molecular beacons

Research findings raise hope for new heart therapies

Study identifies new tool to accurately analyze mtDNA deletions associated with diseases, aging

Researchers identify novel mechanism that particular superbug uses to fend off antibiotic

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