Proliferation News and Research

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Surprising discovery about BH4 may rekindle interest in once-promising pathway

In 2013, renowned Boston Children's Hospital pain researcher Clifford Woolf, MB, BCh, PhD, and chemist Kai Johnsson, PhD, his fellow co-founder at Quartet Medicine, believed they held the key to non-narcotic pain relief.

19 Nov 2018

Reducing cellular proliferation could help deplete HIV reservoir and lead to a functional cure

A majority of the HIV-infected cells that persist in HIV-infected individuals even during suppressive antiretroviral therapy originated from cellular proliferation, not viral replication, according to new research published in Nature Communications.

17 Nov 2018

New method to extend cell division and immortalization of avian-derived cells

The number of critically endangered animals has been increasing in recent years. According to data from the International Union for the Conservation of Nature, 1375 avian species are categorized as being endangered animals, and around 12% of the endangered species are avian.

16 Nov 2018

CRISPR-based tool shown to enhance cell-based immunotherapy

Researchers have developed a CRISPR-based tool called SLICE that can boost the effectiveness of immune cell therapies.

15 Nov 2018

Researchers evaluate efficacy of salivary biomarkers for early detection of oral cancer

Over 90% of malign tumors in the head and neck are originated from carcinomas of squamous cells that appear in superficial areas of the oral cavity. Their detection with salivary biomarkers can contribute to their early treatment, before they transform into tumors.

14 Nov 2018

Two genomic tests help identify most effective treatment for breast cancer patients

New results from a long-running trial to identify which new drugs or combinations of drugs are most effective in which types of breast cancer, show that two genomic tests are bringing the era of truly personalized medicine ever nearer.

14 Nov 2018

Study defines biomarker in response to treatment of castration-resistant prostate cancer

The most aggressive type of prostate cancer, castration-resistant prostate cancer, can be treated with two different therapies: taxanes or hormone treatment. Until this day there are no comparative studies between the two and the decision on which treatment to use is done empirically and based on the patient's preferences.

14 Nov 2018

Growth and spread of deadly eye tumor suppressed in cells, animals

By comparing genetic sequences in the eye tumors of children whose cancers spread with tumors that didn't spread, Johns Hopkins Medicine researchers report new evidence that a domino effect in cells is responsible for the cancer spreading.

12 Nov 2018

All infectious diseases likely to be seasonal

A new study has suggested that all infectious diseases are driven by seasonal elements, based on an analysis of 69 infectious diseases.

9 Nov 2018

Dietary restriction could help prevent age-related decline in integrity of human gut

Flies eating a Spartan diet are protected from leaky gut and the systemic inflammation associated with it as they age. Conversely, flies on a rich Atkins-like diet are more prone to developing intestinal permeability, a condition linked to a variety of human conditions including inflammatory bowel disease.

5 Nov 2018

MCG selected as designated laboratory for NCI-MATCH trial

The Georgia Esoteric and Molecular Laboratory at the Medical College of Georgia at Augusta University has been selected as a designated laboratory for the National Cancer Institute's Molecular Analysis for Therapy Choice, or MATCH trial, which is assessing the effectiveness of targeting cancer-causing gene changes rather than cancer type.

1 Nov 2018

UCLA researchers investigate how a protein factor contributes to cancer cell migration

UCLA researchers have discovered a new protein factor that contributes to a fibroblast cell's ability to migrate to a wound and participate in its healing process. The study's results could help scientists prevent cancer cells from using the same mechanisms to move throughout the body and spread.

1 Nov 2018

Study: Single protein regulates network of genes essential for sperm development

A single protein regulates a battery of key genes inside developing sperm, according to a new study out of Case Western Reserve University School of Medicine.

31 Oct 2018

Individual heart cells respond differently to high blood pressure

A team of cardiologists have found that single cells within the heart are affected by high blood pressure in different ways. Some adapt, whilst others fail.

30 Oct 2018

Insights into tumor initiation pave way for new skin cancer treatments

Researchers from VIB and KU Leuven uncovered a key vulnerability of melanoma. While studying the role of the melanoma-specific long non-coding RNA SAMMSON in tumor initiation, the researchers found that it boosts protein synthesis in different cellular compartments. Normal cells are alerted by modification in protein synthesis and react to this threat, but only if this process is altered in one compartment at the time.

29 Oct 2018

Novel bioreactor allows ultrasonic monitoring of human cartilage grown in 3D

A team of Spanish scientists has designed a bioreactor that allows to grow, in four weeks, human cartilage tissues in scaffolds generated by 3D printing.

29 Oct 2018

Researchers identify new potential target to inhibit progression of liver disease

Naglaa Shoukry, Ph. D., and her team have made a significant breakthrough in their research aiming to limit the progression of liver disease.

26 Oct 2018

Validation of non-invasive stent monitoring techniques

Researchers from the Research Institute Germans Trias i Pujol, the Biomedical Research Networking Center on Cardiovascular Diseases, the University of Barcelona and the the Universitat Politècnica de Catalunya have created a new field probe to detect in a non-invasive and non-ionizing way the presence of metallic stents as well as their potential structural failures through microwave spectrometry.

25 Oct 2018

Skin cells show minimal damage, maximum pigmentation when exposed to sunlight every 48 hours

Skin cells show the least amount of DNA damage and produce the most amount of melanin when exposed to sunlight in 48 hour windows, according to new study.

25 Oct 2018

Incyte announces Phase 2 FIGHT-202 trial data in patients with cholangiocarcinoma

Incyte Corporation announces updated data from its ongoing Phase 2 FIGHT-202 trial evaluating pemigatinib (INCB54828), its selective fibroblast growth factor receptor (FGFR) inhibitor, in patients with advanced/metastatic or surgically unresectable cholangiocarcinoma (bile duct cancer) who failed at least one previous treatment.

22 Oct 2018

Proliferation News and Research

Surprising discovery about BH4 may rekindle interest in once-promising pathway

Reducing cellular proliferation could help deplete HIV reservoir and lead to a functional cure

New method to extend cell division and immortalization of avian-derived cells

CRISPR-based tool shown to enhance cell-based immunotherapy

Researchers evaluate efficacy of salivary biomarkers for early detection of oral cancer

Two genomic tests help identify most effective treatment for breast cancer patients

Study defines biomarker in response to treatment of castration-resistant prostate cancer

Growth and spread of deadly eye tumor suppressed in cells, animals

All infectious diseases likely to be seasonal

Dietary restriction could help prevent age-related decline in integrity of human gut

MCG selected as designated laboratory for NCI-MATCH trial

UCLA researchers investigate how a protein factor contributes to cancer cell migration

Study: Single protein regulates network of genes essential for sperm development

Individual heart cells respond differently to high blood pressure

Insights into tumor initiation pave way for new skin cancer treatments

Novel bioreactor allows ultrasonic monitoring of human cartilage grown in 3D

Researchers identify new potential target to inhibit progression of liver disease

Validation of non-invasive stent monitoring techniques

Skin cells show minimal damage, maximum pigmentation when exposed to sunlight every 48 hours

Incyte announces Phase 2 FIGHT-202 trial data in patients with cholangiocarcinoma

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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