Preclinical News and Research

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HIV drug stops disease progression in 25% of patients with fourth-line metastatic colorectal cancer

New clinical research shows that lamivudine, a reverse transcriptase inhibitor widely used in HIV therapy, stopped disease progression in 25% of patients with fourth-line metastatic colorectal cancer.

5 Apr 2022

Exercise prior to tumor bearing may help reduce the effects of wasting syndrome

A new study has identified yet another benefit of keeping up your exercise routine. In experiments performed with mice, researchers found that exercising prior to developing cancer was associated with slower tumor growth and helped reduce the effects of a cancer complication known as wasting syndrome, or cachexia.

4 Apr 2022

Multi-mineral supplement could help reduce downstream consequences of fatty liver disease

Results from a preclinical study add new evidence that a multi-mineral dietary supplement known as Aquamin could be a simple and effective way to reduce the long-term health consequences of non-alcoholic fatty liver disease.

3 Apr 2022

GE-led team uses ultrasound to prevent or reverse Type-2 diabetes in preclinical models

Are we moving closer to the day when diabetes is no longer monitored and managed with blood sugar tests, insulin injections and drug treatments? A GE Research-led team, which includes The Feinstein Institutes for Medical Research, UCLA Samueli School of Engineering, Yale School of Medicine, and Albany Medical College, has demonstrated the ability to prevent or reverse the onset of diabetes in studies of three different preclinical model systems.

31 Mar 2022

Messenger ribonucleic acid boosters shown to be effective against Omicron infections in mice

Researchers evaluated the protection conferred by booster doses of the preclinical version of the Moderna mRNA-1273 vaccine and a SARS-CoV-2 Omicron variant-matched vaccine against Omicron infections in mice.

31 Mar 2022

Nanotherapies may benefit preterm babies with bronchopulmonary dysplasia

Very premature babies need extra oxygen and mechanical intervention to breathe, but this damages their lungs, causing a chronic lung disease called bronchopulmonary dysplasia (BPD).

30 Mar 2022

Discovering a new possible treatment for COVID-19

In this interview, we speak to Dr. Ahmed G. Ibrahim about his latest research that has discovered a new possible treatment for COVID-19.

30 Mar 2022

Divalent SARS-CoV-2 fusion vaccine found to be effective in mice

Researchers bioengineered a divalent fusion vaccine by combining the immunogenic region of the nucleocapsid protein and the receptor-binding domain of the spike protein of SARS-CoV-2.

30 Mar 2022

Preclinical investigation of intranasal adjuvanted COVID-19 vaccine

A new study reported systemic and mucosal immunity against SARS-CoV-2 via intranasal delivery of a vaccine containing recombinant SARS-CoV-2 antigens, nucleocapsid, and spike subunit.

30 Mar 2022

Good hydration may be linked with reduced risk of heart failure

Staying well-hydrated may be associated with a reduced risk for developing heart failure, according to researchers at the National Institutes of Health.

29 Mar 2022

The different actions of CBD in SARS-CoV-2 infection

An article has described the role of cannabidiol as a potential inhibitor of hyperinflammation in SARS-CoV-2 infection.

29 Mar 2022

Newcastle disease virus-based trivalent vaccine found to be effective across SARS-CoV-2 variants in mice

In a new study, researchers tested the bi-, tri-, and tetravalent formulations of Newcastle disease virus (NDV)-based low-cost vaccine in mice.

29 Mar 2022

Magneto-activated natural killer cells for treating solid tumors

Cancer immunotherapy - a type of treatment that enlists our own immune cells to attack tumors - has revolutionized the way that many types of cancer are treated. One type of immunotherapy under investigation uses natural killer cells, a type of immune cell that can seek and destroy harmful cells.

28 Mar 2022

INRS professor developing a glycoconjugate vaccine for melioidosis

The threat from Melioidosis is real. The bacterium that causes this infectious multisymptom illness is resistant to antibiotics, making diagnosis and treatment more complex and resulting in a mortality rate of up to 50%.

24 Mar 2022

Study identified multiple siRNAs spanning the SARS-CoV-2 genome with potent antiviral activity

A recent study demonstrated that RNA interference could prophylactically protect against SARS-CoV-2.

24 Mar 2022

Scientists develop first drug to treat uncontrolled secretion of mucins in the airways

A multicenter research team co-led by The University of Texas MD Anderson Cancer Center developed the first drug to treat the uncontrolled secretion of mucins in the airways, which causes potentially life-threatening symptoms in millions of Americans with asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF), as well as lung disease resulting from cancer and cancer treatment.

23 Mar 2022

FDA approves new treatment for patients with metastatic melanoma based on Johns Hopkins research

The U.S. Food and Drug Administration has approved a novel therapy for patients with metastatic or inoperable melanoma, an aggressive type of skin cancer.

23 Mar 2022

CD63-expressing extracellular vesicles neutralize SARS-CoV-2 variants of concern

Researchers evaluate antiviral effects of CD63 tetraspanin extracellular vesicles against SARS-CoV-2 and HIV-1.

22 Mar 2022

Study: Ketogenic diet helps kill pancreatic cancer cells when combined with a triple-drug therapy

The findings of a new study suggest that a ketogenic diet - which is low in carbohydrates and protein, but high in fat - helps to kill pancreatic cancer cells when combined with a triple-drug therapy developed by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope.

22 Mar 2022

Oral drug that reverses immune aging effectively prevents death in COVID-19 mouse model

The immune system deteriorates with age, making COVID-19 particularly deadly in older people - but to date, no clinically available medication addresses this key risk factor.

21 Mar 2022

Preclinical News and Research

HIV drug stops disease progression in 25% of patients with fourth-line metastatic colorectal cancer

Exercise prior to tumor bearing may help reduce the effects of wasting syndrome

Multi-mineral supplement could help reduce downstream consequences of fatty liver disease

GE-led team uses ultrasound to prevent or reverse Type-2 diabetes in preclinical models

Messenger ribonucleic acid boosters shown to be effective against Omicron infections in mice

Nanotherapies may benefit preterm babies with bronchopulmonary dysplasia

Discovering a new possible treatment for COVID-19

Divalent SARS-CoV-2 fusion vaccine found to be effective in mice

Preclinical investigation of intranasal adjuvanted COVID-19 vaccine

Good hydration may be linked with reduced risk of heart failure

The different actions of CBD in SARS-CoV-2 infection

Newcastle disease virus-based trivalent vaccine found to be effective across SARS-CoV-2 variants in mice

Magneto-activated natural killer cells for treating solid tumors

INRS professor developing a glycoconjugate vaccine for melioidosis

Study identified multiple siRNAs spanning the SARS-CoV-2 genome with potent antiviral activity

Scientists develop first drug to treat uncontrolled secretion of mucins in the airways

FDA approves new treatment for patients with metastatic melanoma based on Johns Hopkins research

CD63-expressing extracellular vesicles neutralize SARS-CoV-2 variants of concern

Study: Ketogenic diet helps kill pancreatic cancer cells when combined with a triple-drug therapy

Oral drug that reverses immune aging effectively prevents death in COVID-19 mouse model

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