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Alnylam presents positive ongoing phase 2 open-label extension data for Patisiran and Revusiran

Alnylam Pharmaceuticals, Inc. has announced new results from its ongoing Phase 2 open-label extension (OLE) studies with patisiran and revusiran, investigational RNAi therapeutics targeting transthyretin (TTR) for the treatment of TTR-mediated amyloidosis (ATTR amyloidosis).

3 Nov 2015

Hypersexual disorder can be linked to hyperactive stress systems

New research from Karolinska Institutet in Sweden shows that hypersexual disorder - known popularly as sex addiction - can be linked to hyperactive stress systems. In a stress regulation test using the cortisone drug dexamethasone, men with hypersexual disorder showed higher levels of stress hormones than controls, a finding that the researchers hope will contribute to improved therapy for this patient group.

3 Nov 2015

Patients with Down syndrome face additional challenge of early-onset dementia

Individuals with Down syndrome who survive into adulthood face the additional challenge of early-onset dementia, in which toxic amyloid plaques build up in the brain. The condition is strikingly similar to Alzheimer's disease, and as new work led by researchers at the Lewis Katz School of Medicine at Temple University shows, dementia in Down syndrome involves defects in a regulatory enzyme known as γ-secretase activating protein (GSAP), which also happens to malfunction in Alzheimer's disease.

3 Nov 2015

UCLA study finds cost variation across entire care process for low-risk prostate cancer

Now, for the first time, UCLA researchers have described cost across an entire care process for low-risk prostate cancer - from the time a patient checks in for his first appointment to his post-treatment follow-up testing - using time-driven activity-based costing. And they found a wide variation in costs for the various available treatments that remained consistent over a 12-year period, indicating a better method to monitor costs could save valuable healthcare dollars, said study first author Dr. Aaron Laviana, a fifth year urology resident.

3 Nov 2015

Findings suggest potential metabolic pathway against cancer

When cancer cells compete with immune cells for glucose, the cancer wins. As a result, the immune T cells are not healthy and don't have the weapons to kill the cancer.

3 Nov 2015

Researchers take new approach to understanding obstacles to breast cancer care in Appalachia

Researchers at the University of Virginia School of Medicine have taken a new approach to understanding why so many breast cancer patients in Appalachia aren't getting the care they need, and their findings are set to change how people view the obstacles to care that beset the region.

3 Nov 2015

Discovery offers promising alternative to current therapies for AMD and ROP

A research team led by scientists at Beth Israel Deaconess Medical Center and the University of New Mexico School of Medicine has identified a small molecule that treats animal models of aged macular degeneration (AMD) and retinopathy of prematurity (ROP) by preventing the overgrowth of blood vessels that are characteristic of these two retinal diseases.

3 Nov 2015

Researchers identify tumor suppressor genes that drive subset of melanomas

Of the hundreds of genes that can be mutated in a single case of melanoma, only a handful may be true "drivers" of cancer. In research that appeared today in Nature Genetics, a Weizmann Institute of Science team has now revealed one of the drivers of a particularly deadly subset of melanomas - one that is still seeing a rise in new cases. This gene is a newly identified member of a group of genes called tumor suppressor genes.

3 Nov 2015

United Cannabis files utility and PCT patent applications related to unique specifications of cannabinoids

United Cannabis Corporation today announced that it moved its provisional patent application to the next phase by filing a utility patent application related to the unique combinations of pharmaceutically active cannabinoids used to treat disorders of the nervous system, immune system and cancer with the U.S. Patent and Trademark Office.

3 Nov 2015

CPFN, Cure CP raise funds to extend research on cerebral palsy

Will it one day be possible to cure cerebral palsy? Scientists working in a new field of study known as "regenerative medicine" think so. But support is needed to further the research, according to two non-profit organizations founded by parents of children with CP.

2 Nov 2015

Cancer DNA in patient's bloodstream could help deliver personalized treatment for liver cancer

Fragments of cancer DNA circulating in a patient's bloodstream could help doctors deliver more personalized treatment for liver cancer, Japanese researchers report.

2 Nov 2015

Findings provide a step towards personalized cancer therapy

Oxford University researchers have found the Achilles heel of certain cancer cells - mutations in a gene called SETD2. Their findings will be presented to the National Cancer Research Institute conference in Liverpool this Monday (2 Nov 15).

2 Nov 2015

Patients offered animal-assisted therapy at UCLA Health

At UCLA Health, patients are offered a special kind of therapy that does not involve needles, medicine or high-tech machines.

31 Oct 2015

New method helps study chaotic genomes of cancer cells more precisely than ever before

Scientists of the Luxembourg Centre for Systems Biomedicine of the University of Luxembourg have developed a method for analysing the genome of cancer cells more precisely than ever before.

31 Oct 2015

Unique funding opportunity seeks countermeasures to protect healthy tissue from radiation exposure

Small U.S.-based companies developing countermeasures to protect healthy tissue from the effects of radiation exposures may be eligible for a unique funding opportunity offered through the National Space Biomedical Research Institute. NSBRI's Industry Forum is soliciting applications for its Space Medical and Related Technologies Commercialization Assistance Program (SMARTCAP).

31 Oct 2015

Resistance to CD19 CAR T-cell therapy can be caused by CD19 splicing alterations

Resistance to CD19 CAR T-cell therapy, a type of immunotherapy that yields long-lasting remissions in many patients with B-cell leukemia, can be caused by CD19 splicing alterations, leading to loss of certain parts of the CD19 protein that are recognized by the CAR T cells.

31 Oct 2015

People with psychosis and addiction disorder may respond better to disorder-specific treatment

People with psychosis often develop an addiction disorder: almost one in two patients with schizophrenia are affected once during their lifetime. Patients with a dual diagnosis mostly have a poorer prognosis, and their disorder often becomes chronic.

31 Oct 2015

UCSD researchers develop new computational strategy to find tumor-shrinking molecules

Patients with glioblastoma, a type of malignant brain tumor, usually survive fewer than 15 months following diagnosis. Since there are no effective treatments for the deadly disease, University of California, San Diego researchers developed a new computational strategy to search for molecules that could be developed into glioblastoma drugs. In mouse models of human glioblastoma, one molecule they found shrank the average tumor size by half.

31 Oct 2015

Blocking calcium-signaling pathway could inhibit Ebola virus and other sources of deadly infections

The Ebola virus acts fast. The course of infection, from exposure to recovery, or death, can take as little as two weeks. That may not leave enough time for the immune system to mount an effective response.

31 Oct 2015

Miriam Hospital enrolling local participants for Parachute implant clinical trial to treat heart failure

The Miriam Hospital is actively recruiting local participants for a U.S. clinical trial of the Parachute device for treating heart failure. The study is focused on determining if the new minimally invasive catheter-based device can slow the progression of heart failure, reduce repeat hospitalizations and death, and significantly improve quality of life for patients who experience enlargement of the left ventricle after a heart attack.

31 Oct 2015

Therapy News and Research

Alnylam presents positive ongoing phase 2 open-label extension data for Patisiran and Revusiran

Hypersexual disorder can be linked to hyperactive stress systems

Patients with Down syndrome face additional challenge of early-onset dementia

UCLA study finds cost variation across entire care process for low-risk prostate cancer

Findings suggest potential metabolic pathway against cancer

Researchers take new approach to understanding obstacles to breast cancer care in Appalachia

Discovery offers promising alternative to current therapies for AMD and ROP

Researchers identify tumor suppressor genes that drive subset of melanomas

United Cannabis files utility and PCT patent applications related to unique specifications of cannabinoids

CPFN, Cure CP raise funds to extend research on cerebral palsy

Cancer DNA in patient's bloodstream could help deliver personalized treatment for liver cancer

Findings provide a step towards personalized cancer therapy

Patients offered animal-assisted therapy at UCLA Health

New method helps study chaotic genomes of cancer cells more precisely than ever before

Unique funding opportunity seeks countermeasures to protect healthy tissue from radiation exposure

Resistance to CD19 CAR T-cell therapy can be caused by CD19 splicing alterations

People with psychosis and addiction disorder may respond better to disorder-specific treatment

UCSD researchers develop new computational strategy to find tumor-shrinking molecules

Blocking calcium-signaling pathway could inhibit Ebola virus and other sources of deadly infections

Miriam Hospital enrolling local participants for Parachute implant clinical trial to treat heart failure

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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