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Researchers uncover how small heat shock protein interacts with other proteins

In Alzheimer's disease proteins clump together to long fibrils causing the death of nerve cells. Small heat shock proteins can counteract this effect. Scientists, therefore, hope to deploy them as agents in the treatment of neurodegenerative diseases. Using the example of a small heat shock protein, researchers at the Technical University of Munich and the Helmholtz Zentrum Muenchen have now uncovered how the protein interacts with other proteins.

15 Oct 2015

New approaches to treating amblyopia

Amblyopia, commonly known as "lazy-eye," has been classically treated by patching the strong eye to force the weaker eye to be used. However, the concept of binocular dysfunction, in which the brain suppresses the image from the weaker eye in favor of the stronger eye, has motivated new approaches to amblyopia treatment.

15 Oct 2015

New method uses advanced noninvasive neuroimaging to localize and identify epileptic lesions

Epilepsy affects more than 65 million people worldwide. One-third of these patients have seizures that are not controlled by medications. In addition, one-third have brain lesions, the hallmark of the disease, which cannot be located by conventional imaging methods.

15 Oct 2015

AASM's new guideline provides updated recommendations for treatment of circadian rhythm sleep-wake disorders

A new clinical practice guideline published by the American Academy of Sleep Medicine provides clinicians with updated recommendations for the treatment of intrinsic circadian rhythm sleep-wake disorders (CRSWDs).

15 Oct 2015

Gene therapy preserves vision in canine model of late-stage retinitis pigmentosa

Gene therapy preserved vision in a study involving dogs with naturally occurring, late-stage retinitis pigmentosa, according to research funded by the National Eye Institute (NEI), part of the National Institutes of Health. The findings contribute to the groundwork needed to move gene therapy forward into clinical trials for people with the blinding eye disorder, for which there is currently no cure.

15 Oct 2015

Specific gene signature could help predict survival outcomes among children with intermediate-risk RMS

Among children with intermediate-risk rhabdomyosarcoma (RMS) that is negative for a fusion gene, those who had a high score of a specific gene signature called MG5 had poorer survival outcomes compared with those who had a low score of MG5.

15 Oct 2015

New blood test could help pair cancer patients with suitable therapy for their disease

CANCER RESEARCH UK-funded scientists have developed a blood test that could help pair cancer patients with the most suitable therapy for their disease and then track the tumour's progress to see if the treatment is working, according to research published today (Thursday) in Clinical Cancer Research.

15 Oct 2015

New $6.7 million project aims to help kidney dialysis patients live longer

Helping kidney dialysis patients have healthier treatment sessions and longer lives is the goal of a new $6.7 million project at the University of Michigan.

15 Oct 2015

TxCell reviews its manufacturing strategy to focus on R&D and strategic partnerships - its core, high added value businesses

TxCell SA, a biotechnology company developing innovative, personalized T cell immunotherapies using antigen specific regulatory T-cells (Ag-Tregs) for severe chronic inflammatory and autoimmune diseases, announces today that it is operating a strategic review that should result in the outsourcing of all existing and future clinical and commercial manufacturing operations to contract manufacturing organizations (CMOs).

15 Oct 2015

Different Crohn's disease treatments affect children's gut microbes in distinct ways

Different treatments for Crohn's disease in children affects their gut mi-crobes in distinct ways, which has implications for future development of microbial-targeted therapies for these patients, according to a study led by researchers from the Perelman School of Medicine at the University of Pennsylvania.

15 Oct 2015

LEADERS FREE clinical trial demonstrates superior safety, efficacy for BioFreedom compared with bare-metal stent

Biosensors International Group, Ltd., a developer, manufacturer and marketer of innovative medical devices, announced today that the LEADERS FREE clinical trial demonstrated superior safety and efficacy for BioFreedom compared with a bare-metal stent (BMS).

15 Oct 2015

ADMT announces filing of FDA 510(k) application for Angiodroid The CO2 Injector for Angiography

ADM Tronics Unlimited, Inc. has announced that a Premarket Notification 510(k) application has been filed with the US Food and Drug Administration for Angiodroid The CO2 Injector for Angiography (the "Angiodroid Injector") by Angiodroid America, Inc., a subsidiary of Angiodroid, Srl, in affiliation with Triotech Ventures and ADMT, as previously announced.

15 Oct 2015

Long-term lithium exposure does not increase renal dysfunction risk

Stable lithium maintenance therapy does not increase the risk of renal dysfunction in patients with bipolar affective disorder, findings from a population-based study suggest.

14 Oct 2015

enGene, Janssen Biotech sign agreement to develop and commercialize new IBD therapies

enGene, Inc. a gene therapy company focused on development of therapeutics using its proprietary "Gene Pill" and enema gene delivery platform, today announced that it has entered into a definitive agreement with Janssen Biotech, Inc., one of the Janssen Pharmaceutical Companies of Johnson & Johnson, to develop and commercialize new therapies for inflammatory bowel disease (IBD).

14 Oct 2015

New hope for patients with Duchenne muscular dystrophy

New hope for Duchenne muscular dystrophy (DMD) patients. A mouse genetic study in PLoS Medicine reports that targeting the P2RX7 gene, a purinoreceptor, may halt the progression of DMD.

14 Oct 2015

Thyroid hormone treatment improves cardiac health in female rats with high blood pressure

Thyroid hormones administered to female rats with high blood pressure led to encouraging cardiac improvements, according to a study in the American Journal of Physiology led by NYIT College of Osteopathic Medicine researcher Martin Gerdes.

14 Oct 2015

Sense oligonucleotide antidote reverses actions of antisense antithrombotic drug, prevents bleeding

Researchers from Isis Pharmaceuticals (Carlsbad, CA) and Prysis Biotechnologies (Pudong, Shanghai, China) have demonstrated proof-of-concept for using a sense oligonucleotide to undo the effects of an antisense drug, an antithrombotic agent in this novel study.

14 Oct 2015

Insulin dose not independent risk factor for cardiovascular death

A NIH-sponsored double-blinded, randomized clinical trial entitled Action to Control Cardiovascular Risk in Diabetes (ACCORD study) came to a halt seven years ago after patients receiving more intensive diabetes therapy were found to have a higher mortality rate, compared to the standard therapy.

14 Oct 2015

UI Cancer Center and GSU to help reduce cancer-related health disparities in Chicago's south suburbs

The greatest burden of cancer in the Chicago region has moved from the city to the suburbs. The University of Illinois Cancer Center and Governors State University have received a joint four-year, $1.5 million grant from the National Cancer Institute to help both institutions conduct community-based research to reduce cancer-related health disparities in Chicago's south suburbs.

14 Oct 2015

New breakthrough may provide key to understanding how to treat Muscular Dystrophy

New research published today in the journal eLife has demonstrated a new method for observing the behaviour of the protein Dystrophin in a living animal cell, in real-time. This breakthrough may provide a key to understanding how to treat the genetic disease, Muscular Dystrophy.

14 Oct 2015

Therapy News and Research

Researchers uncover how small heat shock protein interacts with other proteins

New approaches to treating amblyopia

New method uses advanced noninvasive neuroimaging to localize and identify epileptic lesions

AASM's new guideline provides updated recommendations for treatment of circadian rhythm sleep-wake disorders

Gene therapy preserves vision in canine model of late-stage retinitis pigmentosa

Specific gene signature could help predict survival outcomes among children with intermediate-risk RMS

New blood test could help pair cancer patients with suitable therapy for their disease

New $6.7 million project aims to help kidney dialysis patients live longer

TxCell reviews its manufacturing strategy to focus on R&D and strategic partnerships - its core, high added value businesses

Different Crohn's disease treatments affect children's gut microbes in distinct ways

LEADERS FREE clinical trial demonstrates superior safety, efficacy for BioFreedom compared with bare-metal stent

ADMT announces filing of FDA 510(k) application for Angiodroid The CO2 Injector for Angiography

Long-term lithium exposure does not increase renal dysfunction risk

enGene, Janssen Biotech sign agreement to develop and commercialize new IBD therapies

New hope for patients with Duchenne muscular dystrophy

Thyroid hormone treatment improves cardiac health in female rats with high blood pressure

Sense oligonucleotide antidote reverses actions of antisense antithrombotic drug, prevents bleeding

Insulin dose not independent risk factor for cardiovascular death

UI Cancer Center and GSU to help reduce cancer-related health disparities in Chicago's south suburbs

New breakthrough may provide key to understanding how to treat Muscular Dystrophy

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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