Central Nervous System News and Research

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Promising drug candidate for chronic intractable itch

If you have an itch, you have to scratch it. But that’s a problem for people with a condition called “chronic intractable itch,” where that itchy sensation never goes away—a difficult-to-treat condition closely associated with dialysis and renal failure.

28 Sep 2015

Cryoport purchases IP rights to Cryoportal operating platform from Klatu

Cryoport, Inc. today announced the purchase of certain intellectual property and intellectual property rights to the Cryoportal operating platform from KLATU Networks, LLC.

24 Sep 2015

Researchers find novel connection between choroid plexus and complex regional pain syndrome

Aalto University neuroscientists, in collaboration with researchers at Helsinki University Hospital and Harvard Medical School, have found a novel connection between the size of the choroid plexus in the brain and complex regional pain syndrome (CRPS).

22 Sep 2015

Disrupting specific signaling pathway in the brain can cause overeating of high fat foods

Defective signaling in the brain can cause overeating of high fat foods in mice, leading to obesity, according to one of the first research articles published in the new open access journal Heliyon.

22 Sep 2015

Bionomics’ BNC210 Phase 1 trial for anxiety and depression meets primary endpoint

Bionomics Limited, a biopharmaceutical company focused on the discovery and development of innovative therapeutics for the treatment of diseases of the central nervous system (CNS) and cancer, today reported positive data from the completed Phase 1 multiple ascending dose, placebo controlled clinical trial of BNC210, an orally administered negative allosteric modulator of the alpha-7 nicotinic acetylcholine receptor (alpha-7 receptor) being developed for the treatment of anxiety and depression.

16 Sep 2015

Fetuses with enlarged ventricles are not ideal candidates for fetal spina bifida surgery

Fetuses with enlarged ventricles--the fluid-filled cavities inside the brain--may be less likely than other fetuses to benefit from surgery in the womb to treat spina bifida, according to a study co-authored by researchers at UCSF Benioff Children's Hospital San Francisco.

16 Sep 2015

Cautiously-designed combination therapies may attenuate side effects associated with Alzheimer's drugs

BACE1 is the major drug target for Alzheimer's disease, but we know surprisingly little about its normal function in the CNS.

15 Sep 2015

Endothelin system offers potential therapeutic target for ALS

Amyotrophic lateral sclerosis (ALS) is a disorder in which cells of the nervous system die, leading to muscle weakness that impacts breathing, movement and other physical functions.

4 Sep 2015

Repeated exposure to anesthesia early in life causes long-term behavioral changes

Repeated exposure to anesthesia early in life causes alterations in emotional behavior that may persist long-term, according to a study from the Icahn School of Medicine at Mount Sinai in collaboration with the Yerkes National Primate Research Center, and published in the Online First edition of Anesthesiology, the official medical journal of the American Society of Anesthesiologists.

4 Sep 2015

Cipla enters into definitive agreements to acquire two US-based companies

Cipla, a global pharmaceutical company which uses technology and innovation to meet the everyday needs of all patients, today announced that its UK arm, Cipla EU has entered into definitive agreements to acquire two US-based companies, InvaGen Pharmaceuticals Inc., and Exelan Pharmaceuticals Inc.

4 Sep 2015

Quest Diagnostics receives FDA 510(k) clearance for Simplexa HSV 1 & 2 Direct molecular test

Quest Diagnostics, the world’s leading provider of diagnostic information services, today announced that its Focus Diagnostics products business has received FDA 510(k) clearance to add the genital swab claim to its Simplexa HSV 1 & 2 Direct molecular test on the Integrated Cycler.

From Quest Diagnostics 4 Sep 2015

Children's Hospital Los Angeles receives $2 million to spur research on brain, spinal cord tumors

A life-changing event for a Los Angeles family has resulted in their funding an endowment to support The Kort Family Foundation Brain and Spinal Cord Tumor Research Program in the Division of Neurosurgery at Children's Hospital Los Angeles.

3 Sep 2015

Finding better treatment for adolescent idiopathic scoliosis

In an effort to find a better treatment for spinal curvature in children and young people, the EU's "StimulAIS" project is focused on electrostimulation of muscles. Fraunhofer scientists worked with partners from industry and research to develop a prototype implant that would do the job.

3 Sep 2015

Bionomics submission of BNC101 IND for cancer treatment passes FDA review

31 Aug 2015

Study shows lack of folic acid enrichment in Europe causes foaetal abnormalities

A new international study shows that 5,000 foetuses in Europe annually are affected by spina bifida and other severe defects on the central nervous system. Seventy per cent of these pregnancies are terminated, while increased mortality and serious diseases affect the children who are born. At least half of the cases can be avoided by adding folic acid to staple foods as is already being done in seventy non-European countries.

29 Aug 2015

Scientists reveal how a common gene mutation in ALS and FTD disrupts normal cell function

Researchers have determined how the most common gene mutation in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) disrupts normal cell function, providing insight likely to advance efforts to develop targeted therapies for these brain diseases.

27 Aug 2015

Researchers find that humans carry more antibiotic-resistant staphylococci than farm animals

Antibiotic-resistant bacteria are a concern for the health and well-being of both humans and farm animals. One of the most common and costly diseases faced by the dairy industry is bovine mastitis, a potentially fatal bacterial inflammation of the mammary gland (IMI). Widespread use of antibiotics to treat the disease is often blamed for generating antibiotic-resistant bacteria.

25 Aug 2015

Researchers awarded $6.4 million grant to identify causes of neurodevelopmental disorders in children with CHDs

As advances in medicine are giving rise to growing numbers of children who are surviving severe heart defects, a phenomenon is emerging that is catching parents and healthcare providers off-guard. Over half of these children also have a seemingly unrelated disability: neurodevelopmental disorders. Some have severe cognitive and motor deficits that arise early.

25 Aug 2015

Valeant enters into definitive agreement to acquire Sprout Pharmaceuticals

Valeant Pharmaceuticals International, Inc. and Sprout Pharmaceuticals, Inc. today announced that they have entered into a definitive agreement under which a wholly-owned subsidiary of Valeant will acquire Sprout, on a debt-free basis, for approximately $1 billion in cash, plus a share of future profits based upon the achievement of certain milestones.

20 Aug 2015

Transplanting mesenchymal stromal cells derived from amniotic membranes can benefit eye diseases

A team of researchers in South Korea has successfully transplanted mesenchymal stromal cells (MSCs) derived from human amniotic membranes of the placenta (AMSCs) into laboratory mice modeled with oxygen-induced retinopathy (a murine model used to mimic eye disease).

20 Aug 2015

Central Nervous System News and Research

Promising drug candidate for chronic intractable itch

Cryoport purchases IP rights to Cryoportal operating platform from Klatu

Researchers find novel connection between choroid plexus and complex regional pain syndrome

Disrupting specific signaling pathway in the brain can cause overeating of high fat foods

Bionomics’ BNC210 Phase 1 trial for anxiety and depression meets primary endpoint

Fetuses with enlarged ventricles are not ideal candidates for fetal spina bifida surgery

Cautiously-designed combination therapies may attenuate side effects associated with Alzheimer's drugs

Endothelin system offers potential therapeutic target for ALS

Repeated exposure to anesthesia early in life causes long-term behavioral changes

Cipla enters into definitive agreements to acquire two US-based companies

Quest Diagnostics receives FDA 510(k) clearance for Simplexa HSV 1 & 2 Direct molecular test

Children's Hospital Los Angeles receives $2 million to spur research on brain, spinal cord tumors

Finding better treatment for adolescent idiopathic scoliosis

Bionomics submission of BNC101 IND for cancer treatment passes FDA review

Study shows lack of folic acid enrichment in Europe causes foaetal abnormalities

Scientists reveal how a common gene mutation in ALS and FTD disrupts normal cell function

Researchers find that humans carry more antibiotic-resistant staphylococci than farm animals

Researchers awarded $6.4 million grant to identify causes of neurodevelopmental disorders in children with CHDs

Valeant enters into definitive agreement to acquire Sprout Pharmaceuticals

Transplanting mesenchymal stromal cells derived from amniotic membranes can benefit eye diseases

Event guide: The 7th CNS Drug Delivery Summit eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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