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MGH study reveals effects of combined radiation and chemotherapy on the brain tissue of glioblastoma patients

A study from Massachusetts General Hospital Cancer Center researchers - the first to examine the effects of combined radiation and chemotherapy on the healthy brain tissue of glioblastoma patients - reveals not only specific structural changes within patients' brains but also that the effect of cancer therapy on the normal brain appears to be progressive and continues even after radiation therapy has ceased.

18 Aug 2015

CML survey reveals patient TKI adherence, disease anxiety

Survey results suggest that chronic myeloid leukaemia patients using tyrosine kinase inhibitor therapy have good adherence to treatment but might benefit from counselling regarding their illness.

17 Aug 2015

HCT not precluded by prior second-generation TKI therapy in chronic, advanced phase CML

Allogeneic haematopoietic stem cell transplantation can be considered for chronic- and accelerated-phase chronic myeloid leukaemia patients with prior exposure to second-generation tyrosine kinase inhibitors, say Polish researchers.

17 Aug 2015

TKI outcomes ‘unfavourable’ in young CML patients

Adolescent and young adult patients with chronic myeloid leukaemia may have an unfavourable outcome on tyrosine kinase inhibitor therapy compared with their older counterparts, suggests a study of Japanese patients.

17 Aug 2015

New OTEMTO phase three results show potential improvement to quality of life for COPD patients

Boehringer Ingelheim announced the publication of new data from the Phase IIIb OTEMTO® 1&2 trials (NCT01964352/NCT02006732), which show Spiolto® Respimat® (tiotropium/olodaterol) provides consistent, clinically meaningful improvements in quality of life versus placebo in patients with COPD

17 Aug 2015

NanoViricides speeds up HerpeCide drug development program

NanoViricides, Inc., a nanomedicine company developing anti-viral drugs, reports that it is accelerating its HerpeCide drug development program.

17 Aug 2015

FDA accepts Chiasma's NDA filing for octreotide capsules for treatment of adult patients with acromegaly

Chiasma, Inc., a U.S. late-stage biopharmaceutical company, today announced that the U.S. Food and Drug Administration has accepted for filing the Company's New Drug Application (NDA) for the marketing and sale of octreotide capsules, an oral drug proposed for the maintenance therapy of adult patients with acromegaly.

17 Aug 2015

Unituxin (dinutuximab) granted EC Marketing Authorisation for treatment of childhood neuroblastoma

United Therapeutics Corporation announced today that the European Commission (EC) has granted Marketing Authorisation for Unituxin (dinutuximab) for the treatment of high-risk neuroblastoma in patients aged 12 months to 17 years, who have previously received induction chemotherapy and achieved at least a partial response, followed by myeloablative therapy and autologous stem cell transplantation (ASCT).

17 Aug 2015

Scientists partner to create liver-on-chip device that mimics human physiology

Safety evaluation is a critical part of drug and cosmetic development. In recent years there is a growing understanding that animal experiments fail to predict the human response, necessitating the development of alternative models to predict drug toxicity.

17 Aug 2015

UT Arlington, UNTHSC researchers develop user-friendly system alerts for people with sleep apnea

Masks worn by those with sleep apnea can leak at night and be so uncomfortable that they often drive users away from treatment. But a new system being developed by researchers at UNT Health Science Center and The University of Texas at Arlington could make it easier for the estimated 18 million people with sleep apnea to get a good night's rest.

14 Aug 2015

Women's Medicine Collaborative awarded NIH grant to study link between placenta and sleep abnormalities

The National Institutes of Health has awarded $2.7 million to the Women's Medicine Collaborative to study the placenta and its function to determine whether changes in the placenta are linked to sleep abnormalities.

14 Aug 2015

HCT not precluded by prior second-generation TKI therapy in chronic, advanced phase CML

14 Aug 2015

CML survey reveals patient TKI adherence, disease anxiety

Survey results suggest that chronic myeloid leukaemia patients using tyrosine kinase inhibitor therapy have good adherence to treatment but might benefit from counselling regarding their illness.

14 Aug 2015

TKI outcomes ‘unfavourable’ in young CML patients

14 Aug 2015

New system accurately and reliably captures patient experience with cancer drug side effects

In cancer clinical trials, symptom side effects patients experience, like nausea, are typically reported by doctors, and not directly by patients. Previous research has shown that doctors under-report these symptoms.

14 Aug 2015

Dietitians skilled in integrative medical nutrition therapy could benefit patients

Integrative medicine is a quickly expanding field of health care that emphasizes nutrition as a key component. Dietitians and nutritionists have an opportunity to meet workforce demands by practicing dietetics and integrative medicine (DIM). A new JACN article, The Next Generation of Dietitians: Implementing Dietetics Education and Practice in Integrative Medicine describes a DIM education program and practicum. The review article appears in the Journal of the American College of Nutrition (JACN), official publication of the American College of Nutrition.

14 Aug 2015

Arterial shunt in hybrid palliation better for hypoplastic left heart syndrome treatment

Children born with the major congenital heart defect hypoplastic left heart syndrome (HLHS) often must undergo a series of corrective surgeries beginning at birth. While most have the standard three-stage Norwood procedure, a hybrid strategy has been introduced to offset some disadvantages associated with the Norwood surgeries. In a report in The Journal of Thoracic and Cardiovascular Surgery, investigators compare whether outcomes can be improved if an arterial shunt is used as a source of pulmonary blood flow rather than the more conventional venous shunt as part of the hybrid strategy of HLHS surgical reconstruction.

14 Aug 2015

Improved method for building proteins into antibodies

Some proteins exist so fleetingly in the bloodstream that they can't be given effectively as therapies. However, building them into larger proteins, such as antibodies, can make them persist long enough to be useful. Now a team led by scientists at The Scripps Research Institute (TSRI) has devised an improved method for accomplishing this protein-engineering feat.

14 Aug 2015

Ontario nearing ambitious UN targets for ending AIDS epidemics

A new study suggests Ontario is nearing ambitious United Nations targets for ending the AIDS epidemics: By 2020, 90 per cent of all people living with HIV should know their HIV status, 90 per cent of all people diagnosed with HIV are receiving sustained antiretroviral drug therapy and 90 per cent of people on ART have a very low or undetectable levels of the virus.

14 Aug 2015

PHIV children may lack immunity against measles, mumps, and rubella despite vaccination

Between one-third and one-half of individuals in the United States who were infected with HIV around the time of birth may not have sufficient immunity to ward off measles, mumps, and rubella--even though they may have been vaccinated against these diseases.

14 Aug 2015

Therapy News and Research

MGH study reveals effects of combined radiation and chemotherapy on the brain tissue of glioblastoma patients

CML survey reveals patient TKI adherence, disease anxiety

HCT not precluded by prior second-generation TKI therapy in chronic, advanced phase CML

TKI outcomes ‘unfavourable’ in young CML patients

New OTEMTO phase three results show potential improvement to quality of life for COPD patients

NanoViricides speeds up HerpeCide drug development program

FDA accepts Chiasma's NDA filing for octreotide capsules for treatment of adult patients with acromegaly

Unituxin (dinutuximab) granted EC Marketing Authorisation for treatment of childhood neuroblastoma

Scientists partner to create liver-on-chip device that mimics human physiology

UT Arlington, UNTHSC researchers develop user-friendly system alerts for people with sleep apnea

Women's Medicine Collaborative awarded NIH grant to study link between placenta and sleep abnormalities

HCT not precluded by prior second-generation TKI therapy in chronic, advanced phase CML

CML survey reveals patient TKI adherence, disease anxiety

TKI outcomes ‘unfavourable’ in young CML patients

New system accurately and reliably captures patient experience with cancer drug side effects

Dietitians skilled in integrative medical nutrition therapy could benefit patients

Arterial shunt in hybrid palliation better for hypoplastic left heart syndrome treatment

Improved method for building proteins into antibodies

Ontario nearing ambitious UN targets for ending AIDS epidemics

PHIV children may lack immunity against measles, mumps, and rubella despite vaccination

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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