Immune System News and Research

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Designing hybrid antibodies with enhanced mobility and signaling capacity

Antibodies are the body's superheroes, recognizing and eliminating disease-causing substances.

25 Jun 2024

FDA expands orphan drug designation for Roswell Park's brain cancer immunotherapy

The U.S. Food and Drug Administration (FDA) has expanded orphan drug designation for SurVaxM, a brain cancer immunotherapy born in the labs of Roswell Park Comprehensive Cancer Center.

25 Jun 2024

Open-source platform enables high-definition spatial transcriptomics

An open-source platform developed by researchers in Nikolaus Rajewsky's lab at the Max Delbrück Center creates molecular maps from patient tissue samples with subcellular precision, enabling detailed study and potentially enhancing routine clinical pathology. The study was published in "Cell."

25 Jun 2024

Enhancing adoptive T-cell therapy with nanowire innovation

Adoptive T-cell therapy has revolutionized medicine. A patient's T-cells - a type of white blood cell that is part of the body's immune system - are extracted and modified in a lab and then infused back into the body, to seek and destroy infection, or cancer cells.

24 Jun 2024

Brazilian researchers identify possible biomarkers associated with recurrence of vivax malaria

The most common type of malaria in Brazil is caused by the parasite Plasmodium vivax. Although vivax malaria is milder than the variant caused by P. falciparum, the ability of P. vivax to produce dormant forms in the host's liver that can be reactivated months after the end of treatment makes it very hard to control.

24 Jun 2024

Will it soon be possible for doctors to use AI to detect and diagnose cancer?

Researchers developed binary and multiclass machine learning models to distinguish cancer from non-cancerous tissue samples.

24 Jun 2024

JAK1 inhibition and Anti-PD1 therapy enhance outcomes in advanced lung cancer

Adding an anti-inflammatory drug to anti-PD1 checkpoint inhibitor immunotherapy has shown great promise as a new strategy against advanced lung cancer, based on results from a small clinical trial led by investigators at the Abramson Family Cancer Center at the University of Pennsylvania Perelman School of Medicine.

21 Jun 2024

Combination therapy shows great promise as a new strategy against advanced lung cancer

21 Jun 2024

Pennington Biomedical researchers partner on award-winning long COVID study

Dr. John Kirwan, Executive Director of Pennington Biomedical Research Center, is serving as a co-principal investigator on the Pathobiology in RECOVER of Metabolic and Immune Systems, or PROMIS, study.

21 Jun 2024

Cannabis use tied to increased risk of severe COVID-19

As the deadly disease that came to be known as COVID-19 started spreading in late 2019, scientists rushed to answer a critical question: Who is most at risk?

21 Jun 2024

Regular IgG monitoring and replacement therapy reduce severe infections in CLL and NHL patients

Patients with chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphomas (NHLs) who received frequent tests for immunoglobulin G (IgG) were less likely to experience severe infections compared with those who didn't, according to a study published in Blood Advances.

21 Jun 2024

Using deep learning to design synthetic soluble versions of cell membrane proteins

Many drug and antibody discovery pathways focus on intricately folded cell membrane proteins: when molecules of a drug candidate bind to these proteins, like a key going into a lock, they trigger chemical cascades that alter cellular behavior.

21 Jun 2024

Combining JAK inhibitors with checkpoint inhibitors improves cancer immunotherapy response

Because not all cancer patients respond to a leading type of cancer immunotherapy drug, known as an immune checkpoint inhibitor, scientists explored whether adding janus kinase (JAK) inhibitors – drugs that treat chronic inflammation – could help.

20 Jun 2024

JAK inhibitor ruxolitinib enhances immunotherapy in Hodgkin lymphoma patients

Checkpoint inhibitor therapies can be thought of as the molecular "brake release" for the immune system.

20 Jun 2024

Less healthy intestinal flora could increase the risk of serious infection

The composition of the intestinal flora can predict the chances of developing serious infections such as pneumonia.

20 Jun 2024

Unveiling the role of auto-antibodies in COVID-19 severity

Even though COVID-19 manifests as a mild and short-lived disease in most people, some suffer extremely severe symptoms; in the worst cases, these patients die due to complications such as respiratory failure or thromboembolism.

19 Jun 2024

Harnessing post-translational modifications for a tuberculosis booster vaccine

Tuberculosis is still one of the deadliest infectious diseases, causing over one million deaths each year worldwide.

19 Jun 2024

Perinatal depression linked to higher long-term cardiovascular disease risk in women

Women diagnosed with perinatal depression are more likely to develop cardiovascular disease in the following 20 years compared to women who have given birth without experiencing perinatal depression, according to research published in the European Heart Journal today (Wednesday).

19 Jun 2024

Unlocking the role of B cells in neuromyelitis optica spectrum disorder treatment

Autoimmune diseases cannot currently be cured, only treated, and this is also true for neuromyelitis optica spectrum disorder, which affects the central nervous system.

19 Jun 2024

New Swiss research institute to pioneer immune engineering and global child health

“Swiss research institute established to focus on immune engineering and advancing global child and adolescent health.”

19 Jun 2024

Immune System News and Research

Designing hybrid antibodies with enhanced mobility and signaling capacity

FDA expands orphan drug designation for Roswell Park's brain cancer immunotherapy

Open-source platform enables high-definition spatial transcriptomics

Enhancing adoptive T-cell therapy with nanowire innovation

Brazilian researchers identify possible biomarkers associated with recurrence of vivax malaria

Will it soon be possible for doctors to use AI to detect and diagnose cancer?

JAK1 inhibition and Anti-PD1 therapy enhance outcomes in advanced lung cancer

Combination therapy shows great promise as a new strategy against advanced lung cancer

Pennington Biomedical researchers partner on award-winning long COVID study

Cannabis use tied to increased risk of severe COVID-19

Regular IgG monitoring and replacement therapy reduce severe infections in CLL and NHL patients

Using deep learning to design synthetic soluble versions of cell membrane proteins

Combining JAK inhibitors with checkpoint inhibitors improves cancer immunotherapy response

JAK inhibitor ruxolitinib enhances immunotherapy in Hodgkin lymphoma patients

Less healthy intestinal flora could increase the risk of serious infection

Unveiling the role of auto-antibodies in COVID-19 severity

Harnessing post-translational modifications for a tuberculosis booster vaccine

Perinatal depression linked to higher long-term cardiovascular disease risk in women

Unlocking the role of B cells in neuromyelitis optica spectrum disorder treatment

New Swiss research institute to pioneer immune engineering and global child health

Understanding the DNA Damage Response in Innate Immunity eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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