Preclinical News and Research

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Study uncovers new clues about the cellular processes that can lead to androgen deficiency

A laboratory study at the Miller School of Medicine's Desai Sethi Urology Institute has uncovered new clues about the cellular processes that can lead to deficiencies of androgens (male hormones) such as testosterone.

4 Mar 2022

Study identifies unique features of MIS-C and how the syndrome gets started in children

A new study by physicians at Columbia University Vagelos College of Physicians and Surgeons has identified unique features of MIS-C, a rare but potentially deadly complication of COVID in children, that suggest how the syndrome gets started.

4 Mar 2022

High-fat diet combined with liquid fructose intake accelerates fat accumulation in the liver

A high-fat diet is not enough to cause short-term fatty liver disease. However, if this diet is combined with the intake of beverages sweetened with liquid fructose, the accumulation of fats in the liver accelerates and hypertriglyceridemia —a cardiovascular risk factor— can appear.

4 Mar 2022

Texas A&M team continues research on the potential cure for Menkes disease

A life-saving cure solution for Menkes Disease, a copper deficiency in young children, is at the center of a licensing agreement by the The Texas A&M University System, through the Intellectual Property and Commercialization office of Texas A&M AgriLife Research, and a California-based biopharmaceutical company, Engrail Therapeutics.

3 Mar 2022

Study provides insight into what causes therapy failure in patients with myelodysplastic syndromes

Researchers from The University of Texas MD Anderson Cancer Center discovered that treatment resistance in patients with myelodysplastic syndromes (MDS) is caused by two distinct classes of stem cells and identified possible therapeutic approaches that target these cells.

3 Mar 2022

Novel approach to generate reliable breast tumor models may pave way for better immunotherapies

The discrepancy between preclinical advances in breast cancer immunotherapy and poor patient outcomes is rooted in the limitations of current breast cancer models. These models often fail to mimic complex interactions between cancer cells and key immune cells present in the tumor microenvironment.

3 Mar 2022

Novel MRI approach can identify brain cell damage in people at early stages of Alzheimer's

Alzheimer's disease usually is diagnosed based on symptoms, such as when a person shows signs of memory loss and difficulty thinking.

2 Mar 2022

Phase 2/3 study of oral RHB-107 in non-hospitalized COVID-19 patients shows promising results

RedHill Biopharma Ltd., a specialty biopharmaceutical company, today announced positive top-line results from the Phase 2 part of the Phase 2/3 study of once-daily oral RHB-107 (upamostat) in non-hospitalized symptomatic COVID-19 patients, predominantly conducted in the U.S. (60/61 patients) as well as South Africa.

1 Mar 2022

Penn Medicine receives $12.3 million NIH grant to study FLASH radiotherapy for cancer

With more than $12 million in new funding from the National Institutes of Health, the Abramson Cancer Center at the University of Pennsylvania will build on its preclinical research of an emerging form of radiation that provides ultra-fast doses - of under a second, compared to several minutes with conventional radiation - and shows promise of greater protection of normal tissue, thereby minimizing toxic effects to the body.

1 Mar 2022

Treatment with Tumor Treating Fields triggers downstream anti-tumor cell response, study finds

Novocure announced that a new study published in the Journal of Clinical Investigation (JCI) finds treatment with Tumor Treating Fields (TTFields) mediated cell disruption activates the immune system and triggers an anti-tumor cell response that may be effectively used together with existing immunotherapy approaches in the treatment of solid tumors, with limited systemic toxicity.

25 Feb 2022

Study uses 3D cervical organoids to show the danger of multiple infections

Infections with several pathogens simultaneously increase the risk of cervical cancer—these results from a study conducted on artificial 3D tissue models.

25 Feb 2022

Why is it Important to Democratize Proteomics Data?

In this interview, we speak to Steve Kosteski from IsoPlexis about the importance of single-cell proteomics within the life sciences sector.

From Society for Laboratory Automation and Screening (SLAS) 23 Feb 2022

Discovery could lead to new treatment approach for people with alcohol-associated liver disease

Investigators at Cedars-Sinai have uncovered a new pathway that helps explain how consuming too much alcohol causes damage to the liver, specifically mitochondrial dysfunction in alcohol-associated liver disease.

22 Feb 2022

Spectrum of autoantibodies linked to autoimmune diseases in patients with different COVID-19 clinical outcomes

A broad evaluation of autoimmune disease-associated autoantibodies that have been observed in COVID-19 patients was performed.

22 Feb 2022

Broad-spectrum antiviral activity of picolinic acid against SARS-CoV-2 and Influenza A virus

Researchers investigate the potential of picolinic acid (PA) as an anti-SARS-CoV-2 treatment option.

21 Feb 2022

New radio-labeled molecule may allow a non-invasive approach to monitor inflammation in real time

Researchers at The University of Texas MD Anderson Cancer Center have developed a new radio-labeled molecule capable of selectively reacting with certain high-energy radicals that are characteristic of innate immune activity, which may allow a non-invasive approach to monitor inflammation in real time by positron emission tomography (PET) imaging.

21 Feb 2022

Codiak's publication highlights the ability of exoASO-STAT6 to selectively target tumor-associated macrophages

Codiak BioSciences, Inc., a clinical-stage biopharmaceutical company pioneering the development of exosome-based therapeutics as a new class of medicines, today announced the online publication of a new manuscript, Exosome mediated genetic reprogramming of tumor associated macrophages by exoASO-STAT6 leads to potent monotherapy anti-tumor efficacy, in the American Association for the Advancement of Science's journal, Science Advances.

18 Feb 2022

Study identifies a protein complex critical for regulating apoptosis and necroptosis

Cell death plays an important role in normal human development and health but requires tightly orchestrated balance to avert disease. Too much can trigger a massive inflammatory immune response that damages tissues and organs. Not enough can interfere with the body's ability to fight infection or lead to cancer.

18 Feb 2022

Study finds antigenic profile of Omicron RBD is distinct from the prior SARS-CoV-2 variants of concern

A new study aimed to clarify whether extensive RBD mutations could affect the magnitude and immunodominance hierarchy of the host antibody response.

18 Feb 2022

Research shows alterations in transfer RNAs at the epigenetic level in cancer

A recently published paper in the journal Molecular Cancer by the group of Dr. Manel Esteller, Director of the Josep Carreras Leukaemia Research Institute, ICREA Research Professor and Genetics Chairman at the University of Barcelona, shows that transfer RNAs for certain amino acids are altered at the epigenetic level in some types of cancer, expressing it in an exaggerated manner in some cases and being deficient in others.

17 Feb 2022

Preclinical News and Research

Study uncovers new clues about the cellular processes that can lead to androgen deficiency

Study identifies unique features of MIS-C and how the syndrome gets started in children

High-fat diet combined with liquid fructose intake accelerates fat accumulation in the liver

Texas A&M team continues research on the potential cure for Menkes disease

Study provides insight into what causes therapy failure in patients with myelodysplastic syndromes

Novel approach to generate reliable breast tumor models may pave way for better immunotherapies

Novel MRI approach can identify brain cell damage in people at early stages of Alzheimer's

Phase 2/3 study of oral RHB-107 in non-hospitalized COVID-19 patients shows promising results

Penn Medicine receives $12.3 million NIH grant to study FLASH radiotherapy for cancer

Treatment with Tumor Treating Fields triggers downstream anti-tumor cell response, study finds

Study uses 3D cervical organoids to show the danger of multiple infections

Why is it Important to Democratize Proteomics Data?

Discovery could lead to new treatment approach for people with alcohol-associated liver disease

Spectrum of autoantibodies linked to autoimmune diseases in patients with different COVID-19 clinical outcomes

Broad-spectrum antiviral activity of picolinic acid against SARS-CoV-2 and Influenza A virus

New radio-labeled molecule may allow a non-invasive approach to monitor inflammation in real time

Codiak's publication highlights the ability of exoASO-STAT6 to selectively target tumor-associated macrophages

Study identifies a protein complex critical for regulating apoptosis and necroptosis

Study finds antigenic profile of Omicron RBD is distinct from the prior SARS-CoV-2 variants of concern

Research shows alterations in transfer RNAs at the epigenetic level in cancer

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