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Roche submits cobas EGFR v2 test PMA to FDA as companion diagnostic test for AZD9291

Roche today announced it has submitted the cobas EGFR Mutation Test v2 for Premarket Approval (PMA) to the U.S. Food and Drug Administration, as a companion diagnostic test for AZD9291, an AstraZeneca investigational therapy for non-small cell lung cancer patients with an acquired resistant mutation.

30 Jul 2015

Astellas reports topline results from isavuconazole Phase 3 study in candidemia and other invasive Candida infections

Astellas today announced topline results from the Phase 3 ACTIVE study evaluating the efficacy and safety of intravenous (IV) and oral isavuconazole, commercially known as CRESEMBA (isavuconazonium sulfate), under development for adults with candidemia and other invasive Candida infections.

30 Jul 2015

New study reports creation of genetic porcine model of cancer

With many types of cancers, early detection offers the best hope for survival. However, research into new early-detection screenings, as well as possible interventional radiology and surgical treatments, has been hindered by the lack of a large animal model that would accurately reflect the types of cancers seen in human cells.

30 Jul 2015

Low blood level of 4 proteins can help diabetics protect against immune attack

Patients with type 1 diabetes have significantly lower blood levels of four proteins that help protect their tissue from attack by their immune system, scientists report.

30 Jul 2015

Protecting gastrointestinal system during radiation or chemotherapy allows patients to tolerate cancer treatments

The stem cells in our gut divide so fast that they create a completely new population of epithelial cells every week. But this quick division is also why radiation and chemotherapy wreak havoc on the gastrointestinal systems of cancer patients - such therapies target rapidly dividing cells.

30 Jul 2015

Vismodegib therapy effective against medulloblastoma

A targeted therapy already used to treat advanced skin cancer is also effective against the most common subtype of the brain tumor medulloblastoma in adults and should be considered for treatment of newly diagnosed patients, according to research led by St. Jude Children's Research Hospital.

30 Jul 2015

Endocrine Society recommends removal of tumor as first-line treatment for endogenous Cushing's syndrome

The Endocrine Society today issued a Clinical Practice Guideline (CPG) on strategies for treating Cushing's syndrome, a condition caused by overexposure to the hormone cortisol.

30 Jul 2015

RepliCel Life Sciences announces final design specifications for next-generation dermal injector

RepliCel Life Sciences Inc., a clinical stage regenerative medicine company, is pleased to announce that the final design specifications of its next-generation dermal injector (RCI-02) have been locked. Prototypes for industrial and regulatory testing will now be built to prepare for an application for CE mark clearance to market the injector in Europe in 2016.

29 Jul 2015

CMC Biologics, River Vision sign manufacturing agreement for Teprotumumab to treat Grave's Orbitopathy

CMC Biologics, a global leader in clinical and commercial manufacturing of therapeutic proteins, and River Vision Development Corporation (River Vision), a private company focused on ophthalmology, announced today that they have entered into an agreement for the process transfer and cGMP production of RV001 (Teprotumumab) – a recombinant monoclonal antibody targeting insulin-like growth factor 1 that is in development for treatment of Grave's Orbitopathy and other indications.

29 Jul 2015

IOF, EOS to jointly hold Middle East & Africa Osteoporosis Meeting in Abu Dhabi

With a growing senior population and an increase in unhealthy lifestyles, the prevalence of osteoporosis and Type 2 Diabetes Mellitus is soaring in the Middle East and North African region. In response to the dramatic increase in these diseases within the region the International Osteoporosis Foundation, in cooperation with the Emirates Osteoporosis Society, will be holding the 3rd Middle East & Africa Osteoporosis Meeting from December 5-7, 2015 in Abu Dhabi.

29 Jul 2015

New tool combines drugs to target kinase dependency in cancer

Targeted therapies attack a cancer's genetic sensitivities. However, it can be difficult to discover the genetics driving a patient's cancer, and the effects of drugs designed to target a genetic abnormality often go beyond their intended target alone. The result is threefold: sometimes a drug is prescribed to treat a target that proves to be irrelevant to the disease, sometimes an existing drug could be used to treat a cancer for which there is no approved targeted therapy, and sometimes a combination of targeted treatments could be used to simultaneously silence more than one genetic cause of a patient's cancer.

29 Jul 2015

BioCision signs deal to develop CoolCell freezing systems for Cook Regentec’s CellSeal vials

BioCision, LLC today announced that they have entered into an exclusive partnership with Cook Regentec to develop two custom CoolCell controlled-rate cell freezing systems for Cook’s closed-system cell therapy CellSeal vials.

29 Jul 2015

Moffitt researchers analyze participation rate of patients in pharmacogenomic trials

Cancer therapy has evolved from a "one-size-fits-all" type of treatment plan to a personalized approach based on a patient's type of cancer, the protein and genetic markers found in their tumors and their response to therapy. Important aspects of the personalized approach are pharmacogenomic studies that analyze associations between genetic variations and patient drug responses.

29 Jul 2015

Facial motion capture technology can help identify different speech disorders in children

Facial motion capture - the same technology used to develop realistic computer graphics in video games and movies - has been used to identify differences between children with childhood apraxia of speech and those with other types of speech disorders, finds a new study by NYU's Steinhardt School of Culture, Education, and Human Development.

29 Jul 2015

CHOP surgeons successfully complete world's first bilateral hand transplant on child

Surgeons at The Children's Hospital of Philadelphia joined with colleagues from Penn Medicine recently to complete the world's first bilateral hand transplant on a child. Earlier this month, the surgical team successfully transplanted donor hands and forearms onto eight-year-old Zion Harvey who, several years earlier, had undergone amputation of his hands and feet and a kidney transplant following a serious infection.

29 Jul 2015

Better pain relief options for individuals with chronic back and leg pain

Chronic back and leg pain sufferers in search of better pain relief options may have a new choice. According to a study published in the Online First edition of Anesthesiology, the official medical journal of the American Society of Anesthesiologists, patients who received a novel high frequency form of spinal cord stimulation (SCS) therapy experienced significantly greater, long-term relief for both chronic back and leg pain, when compared to a traditional low frequency form of SCS therapy.

29 Jul 2015

Despite efforts to improve stroke treatment, delays in emergency transport still prevalent

Despite efforts to close the time gap between symptom onset and stroke treatment - including improvements in public education, 911 dispatch operations, pre-hospital detection and triage, hospital stroke system development, and stroke unit management - a new study presented today at the Society of NeuroInterventional Surgery (SNIS) 12th Annual Meeting suggests that delays in emergency transport are still prevalent and that improvements are needed to ensure patients can be treated within the optimal time window.

28 Jul 2015

Europe has increasing prevalence of fungal resistance, warns ESCMID

The European Society of Clinical Microbiology and Infectious Disease – an organization that explores the risks and best practices in infectious disease – is imploring global healthcare professionals and bodies to take a more active role in the growing problem of fungal resistance.

28 Jul 2015

Innovative new devices that facilitate IA treatment improve outcomes, decrease mortality rates

In the last decade, Intra-Arterial (IA) stroke therapy (a technique in which thrombolytic agents and devices are passed through the arteries directly to the clot site) has gained notable momentum as an effective and safe treatment option for patients.

28 Jul 2015

Helping relieve headaches in school-aged children

As the school year approaches and begins, many parents may start to hear their children complain about headaches.

28 Jul 2015

Therapy News and Research

Roche submits cobas EGFR v2 test PMA to FDA as companion diagnostic test for AZD9291

Astellas reports topline results from isavuconazole Phase 3 study in candidemia and other invasive Candida infections

New study reports creation of genetic porcine model of cancer

Low blood level of 4 proteins can help diabetics protect against immune attack

Protecting gastrointestinal system during radiation or chemotherapy allows patients to tolerate cancer treatments

Vismodegib therapy effective against medulloblastoma

Endocrine Society recommends removal of tumor as first-line treatment for endogenous Cushing's syndrome

RepliCel Life Sciences announces final design specifications for next-generation dermal injector

CMC Biologics, River Vision sign manufacturing agreement for Teprotumumab to treat Grave's Orbitopathy

IOF, EOS to jointly hold Middle East & Africa Osteoporosis Meeting in Abu Dhabi

New tool combines drugs to target kinase dependency in cancer

BioCision signs deal to develop CoolCell freezing systems for Cook Regentec’s CellSeal vials

Moffitt researchers analyze participation rate of patients in pharmacogenomic trials

Facial motion capture technology can help identify different speech disorders in children

CHOP surgeons successfully complete world's first bilateral hand transplant on child

Better pain relief options for individuals with chronic back and leg pain

Despite efforts to improve stroke treatment, delays in emergency transport still prevalent

Europe has increasing prevalence of fungal resistance, warns ESCMID

Innovative new devices that facilitate IA treatment improve outcomes, decrease mortality rates

Helping relieve headaches in school-aged children

Industry Focus eBook - Cell biology (5th edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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