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Researchers reveal how certain lipids help adenoviruses to enter the cell

Adenoviruses cause numerous diseases, such as eye or respiratory infections, and they are widely used in gene therapy. Researchers from the University of Zurich have now discovered how these viruses penetrate the cells, a key step for infection and gene delivery. The cell unwillingly supports virus entry and infection by providing lipids that are normally used to repair damaged membranes.

10 Jul 2015

UTHealth scientist receives $1.9 million from NIH to develop non-antibiotic treatment for C. diff infections

Charles Darkoh, Ph.D., a researcher at The University of Texas Health Science Center at Houston School of Public Health, was recently awarded a five-year, $1.9 million R01 grant by the National Institutes of Health to develop a non-antibiotic treatment for Clostridium difficile (C. diff) infections.

10 Jul 2015

Starting anti-HIV treatment early improves survival among patients with newly diagnosed TB

Starting anti-HIV treatment within two weeks of the diagnosis of tuberculosis, or TB, improved survival among patients with both infections who had very low immune-cell counts, according to an analysis by researchers at the University of Pittsburgh Graduate School of Health.

10 Jul 2015

Four young scientists named recipients of Damon Runyon-Sohn Pediatric Cancer Research Fellowship Award

The Damon Runyon Cancer Research Foundation has named four outstanding young scientists as recipients of the prestigious Damon Runyon-Sohn Pediatric Cancer Research Fellowship Award, committing nearly $875,000 to help address a critical shortage of funding for pediatric cancer research.

10 Jul 2015

Recently-developed drug holds great promise for children with acute lymphoblastic leukaemia

A new Australian study shows that a recently-developed drug, already used safely in adult leukaemia clinical trials, holds great promise for some children with an aggressive form of cancer known as acute lymphoblastic leukaemia (ALL).

10 Jul 2015

Mylan announces launch of Bexarotene 75mg Capsules in U.S.

Mylan N.V. today announced the U.S. launch of Bexarotene 75mg Capsules, which is the generic version of Valeant's Targretin Capsules. This product is indicated for the treatment of cutaneous manifestations of cutaneous t-cell lymphoma in patients who are refractory to at least one prior systemic therapy.

9 Jul 2015

Tillotts Pharma to purchase global rights for AstraZeneca’s Entocort excluding the U.S.

Tillotts Pharma AG, part of the Zeria Group, announced today that it has entered into an agreement for the acquisition of the global rights for Entocort (budesonide) from AstraZeneca, excluding the U.S., which will remain with AstraZeneca.

9 Jul 2015

TSRI study reveals alternative approach to current anti-HIV strategies

HIV-infected patients remain on antiretroviral therapy for life because the virus survives over the long-term in infected dormant cells. Interruption of current types of antiretroviral therapy results in a rebound of the virus and clinical progression to AIDS.

9 Jul 2015

Clinical social workers not integrating discussions about clients' religion, spirituality into counseling sessions

New research by a Baylor University professor shows that licensed clinical social workers (LCSWs), who account for the largest number of clinically trained helping professionals, believe that discussions about their clients' religion and spirituality can often lead to improved health and mental health, but practitioners are not integrating these conversations into their counseling sessions.

9 Jul 2015

Elsevier, NCI implement two-way linking between research articles on ScienceDirect and datasets in caNanoLab

Elsevier, a world-leading provider of scientific, technical and medical information products and services, and the US National Cancer Institute, a world-leading institute for cancer research, today announced that they have implemented two-way linking between research articles on ScienceDirect and datasets stored in NCI's cancer Nanotechnology Laboratory (caNanoLab) data portal.

9 Jul 2015

Bone-tendon-bone grafts and hamstring autografts equally viable options for healing injured ACL

Surgeons making reconstruction choices for an injured ACL can consider both bone-tendon-bone grafts and hamstring autografts as equally viable options in regards to healing, as reported in research today at the American Orthopaedic Society for Sports Medicine's Annual Meeting in Orlando, FL.

9 Jul 2015

Sorrento, NantBioScience form joint venture to develop targeted therapies against cancer

Sorrento Therapeutics, Inc. and NantBioScience, Inc., a majority owned subsidiary of NantWorks, LLC, announced today that they have established a joint venture to focus on the development of 'first-in-class' small molecules against targets that have eluded the pharmaceutical industry to date and which may address important drivers of cancer growth including cancer stem cells.

9 Jul 2015

Janssen-sponsored Phase 2b trial shows guselkumab effective in treating moderate to severe plaque psoriasis

Results published today in The New England Journal of Medicine from a Janssen Research & Development, LLC (Janssen)-sponsored Phase 2b trial showed up to 86 percent of patients with moderate to severe plaque psoriasis receiving guselkumab (CNTO 1959) achieved a Physician's Global Assessment (PGA) score of cleared psoriasis or minimal psoriasis at week 16, the study's primary endpoint.

9 Jul 2015

EvoRx Technologies, AstraZeneca successfully complete research collaboration

AstraZeneca and EvoRx Technologies successfully completed a one-year research collaboration leveraging EvoRx's proprietary Evo-Link technology to discover cell penetrating peptides for a high value intracellular protein–protein interaction target in the respiratory portfolio.

9 Jul 2015

Johns Hopkins, IOCB Prague sign drug discovery research agreement

The Johns Hopkins Drug Discovery (JHDD) program, created with the mission of identifying novel drug targets arising from Johns Hopkins faculty research and translating them into new therapeutics, and the Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences (IOCB Prague) have entered into a five-year drug discovery research agreement to develop small-molecule and peptide drugs for a range of therapeutic areas including neurological diseases, cancer and gastrointestinal disorders.

9 Jul 2015

Phase 3 ODYSSEY JAPAN trial of Praluent injection meets primary endpoint

Regeneron Pharmaceuticals, Inc. and Sanofi today announced that the Phase 3 ODYSSEY JAPAN trial of the investigational therapy Praluent® (alirocumab) Injection met its primary endpoint.

9 Jul 2015

UC San Diego, GSK collaborate to treat leukemia by eliminating cancer stem cells

Researchers at the University of California, San Diego School of Medicine and Moores Cancer Center are working with GSK on a bench-to-bedside project to treat leukemia and other diseases by eliminating cancer stem cells. The collaboration is part of GSK's Discovery Partnerships with Academia (DPAc) program, where academic partners become core members of drug-hunting teams.

9 Jul 2015

International consensus panel reviews new diagnostic criteria for neuromyelitis optica spectrum disorder

New diagnostic criteria were introduced this week for neuromyelitis optica, now called neuromyelitis optica spectrum disorder, which is an inflammatory disease of the central nervous system that is sometimes mistaken for multiple sclerosis.

9 Jul 2015

MGH investigators report that medication could augment benefits of bariatric surgery

New findings about the mechanisms involved - or not involved - in the effects of the most common form of bariatric surgery suggest that combining surgery with a specific type of medication could augment the benefits of the procedure. In a report that has been published online in the journal Endocrinology, Massachusetts General Hospital investigators report that the effects of Roux-en-Y gastric bypass (RYGB) do not utilize neurologic pathways controlled by the serotonin 2C receptor.

9 Jul 2015

Computer model shows how cancerous tumors manipulate blood-vessel growth for their own benefit

Rice University researchers have built a simulation to show how cancerous tumors manipulate blood-vessel growth for their own benefit.

9 Jul 2015

Therapy News and Research

Researchers reveal how certain lipids help adenoviruses to enter the cell

UTHealth scientist receives $1.9 million from NIH to develop non-antibiotic treatment for C. diff infections

Starting anti-HIV treatment early improves survival among patients with newly diagnosed TB

Four young scientists named recipients of Damon Runyon-Sohn Pediatric Cancer Research Fellowship Award

Recently-developed drug holds great promise for children with acute lymphoblastic leukaemia

Mylan announces launch of Bexarotene 75mg Capsules in U.S.

Tillotts Pharma to purchase global rights for AstraZeneca’s Entocort excluding the U.S.

TSRI study reveals alternative approach to current anti-HIV strategies

Clinical social workers not integrating discussions about clients' religion, spirituality into counseling sessions

Elsevier, NCI implement two-way linking between research articles on ScienceDirect and datasets in caNanoLab

Bone-tendon-bone grafts and hamstring autografts equally viable options for healing injured ACL

Sorrento, NantBioScience form joint venture to develop targeted therapies against cancer

Janssen-sponsored Phase 2b trial shows guselkumab effective in treating moderate to severe plaque psoriasis

EvoRx Technologies, AstraZeneca successfully complete research collaboration

Johns Hopkins, IOCB Prague sign drug discovery research agreement

Phase 3 ODYSSEY JAPAN trial of Praluent injection meets primary endpoint

UC San Diego, GSK collaborate to treat leukemia by eliminating cancer stem cells

International consensus panel reviews new diagnostic criteria for neuromyelitis optica spectrum disorder

MGH investigators report that medication could augment benefits of bariatric surgery

Computer model shows how cancerous tumors manipulate blood-vessel growth for their own benefit

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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