Mouse Model News and Research

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Altering gut microbiome may be potential treatment option for PCOS

Symptoms of polycystic ovary syndrome improved with exposure to healthy bacteria in the gut, according to a study in a mouse model of this common women's endocrine disorder.

25 Mar 2019

Nervous system relies on guidance cues for neuronal axons to reach destinations

Similar to the dozens of Sherpas that guide hikers up treacherous Himalayan mountains to reach a summit, the nervous system relies on elaborate timing and location of guidance cues for neuronal axons--threadlike projections--to successfully reach their destinations in the body.

25 Mar 2019

City of Hope exhibits current studies and data on cancer therapies at AACR

City of Hope, a world-renowned independent research and treatment center for cancer and diabetes, will showcase ongoing studies and data on chimeric antigen receptor T cell therapy, immunotherapy against solid tumors and more at the American Association for Cancer Research annual meeting from March 29 through April 3 in Atlanta.

22 Mar 2019

Enzyme inhibitor stops inflammation and neurodevelopmental disorders in mouse models

Work published this week in the journal Proceedings of the National Academy of Sciences shows that an enzyme inhibitor developed by Professor Bruce Hammock and colleagues at UC Davis reduced inflammation in the brains of mice born to mothers with maternal immune activation.

20 Mar 2019

Cholesterol lowering drug can also help treat cancer-associated cachexia

Brazilian researchers have discovered that a drug regularly prescribed to control cholesterol can also be used to treat cachexia, or wasting syndrome, a condition characterized by rapid weight loss and muscle atrophy associated with extreme physical weakness.

19 Mar 2019

GARP protein can be a potential target for immunotherapy against colorectal cancer

Colorectal cancer is the third leading cause of cancer-related deaths in both men and women. Despite significant advances in therapies for this particular cancer, the five-year survival rate is 12 percent, according to the American Cancer Society.

19 Mar 2019

Compounds found in coffee may inhibit growth of prostate cancer

For the first time, scientists have identified compounds found in coffee which may inhibit the growth of prostate cancer. This is a pilot study, carried out on drug-resistant cancer cells in cell culture and in a mouse model; it has not yet been tested in humans.

18 Mar 2019

Exosomes are key to SOS signal that the heart muscle sends out after heart attack, study reveals

Human cells shed exosomes. These tiny extracellular, membrane-bound vesicles can carry cargo for cell-to-cell communication, ferrying diverse loads of proteins, lipids or nucleic acids.

14 Mar 2019

Study suggests new approach to ameliorating obesity-associated metabolic abnormalities

The search by scientists to find ways to combat obesity continues. Recently, investigators have been exploring whether they can engage the lymphatic system to help regulate obesity-induced inflammation of fat (adipose) tissue and restore systemic metabolic fitness.

14 Mar 2019

Increased stress hormones accelerate breast cancer metastasis

It has long been thought that stress contributes to cancer progression. Scientists from the University of Basel and the University Hospital of Basel have deciphered the molecular mechanisms linking breast cancer metastasis with increased stress hormones.

14 Mar 2019

Researchers define pathway that helps us make antibodies

Our bodies are continuously concocting specific antibodies to thwart invaders like a virus or even pollen, and scientists have new information about how the essential production gets fired up and keeps up.

13 Mar 2019

Avocado seed extract could be potential source for novel anti-inflammatory compounds

An extract from the seeds of avocados exhibited anti-inflammatory properties in a laboratory study, according to Penn State researchers, and it represents a potential source for novel anti-inflammatory compounds that could be developed as a functional food ingredient or pharmaceuticals.

13 Mar 2019

Researchers identify potential therapeutic target for blocking early atherosclerosis in progeria

Researchers at the Centro Nacional de Investigaciones Cardiovasculares and the Universidad de Oviedo have discovered a new molecular mechanism involved in the premature development of atherosclerosis in mice with Hutchinson-Gilford progeria syndrome.

12 Mar 2019

CMV airway infection enlarges spectrum of environmental allergens

Cytomegalovirus infection can convert a harmless, inhaled protein antigen into an allergen, according to a study published March 7 in the open-access journal PLOS Pathogens by Rafaela Holtappels from the University Medical Center of the Johannes Gutenberg-University Mainz, and colleagues.

8 Mar 2019

Novel mouse model confirms how “good” and “bad” bacteria affect human acne

Researchers have long believed that Propionibacterium acnes causes acne. But these bacteria are plentiful on everyone's skin and yet not everyone gets acne, or experiences it to the same degree.

8 Mar 2019

Common fungus found on skin may cause inflammatory bowel disease

Therapies that target certain commensal fungi could provide a new way of treating inflammatory bowel disease (IBD), according to researchers.

6 Mar 2019

Aging and high-fat diet disrupt gut microbiome to cause inflammation in heart failure

Growing older and a high-fat diet enriched with omega 6 fatty acids are major contributors to health risks ranging from diabetes to heart failure. How these two factors regulate the immune response is not well-understood.

1 Mar 2019

Research identifies super-enhancers as novel target for pancreatic ductal adenocarcinoma

Differential H3K27AC marks were identified at enhancer regions of genes including c-MYC, MED1, OCT-4, NANOG, and SOX2 that can act as super-enhancers (SE), cluster of genes in non-cancerous, cancerous and metastatic PDAC cell lines.

1 Mar 2019

Scientists find clue to rapid human conversations in singing mice

Studying the songs of mice from the cloud forests of Costa Rica, researchers from New York University School of Medicine and The University of Texas at Austin have identified a brain circuit that might enable the high-speed back and forth of human conversation.

1 Mar 2019

New study explores stem cells to gain insight into rotator cuff disease

Rotator cuff tears are common injuries, and proper healing of the shoulder muscle is often difficult.

27 Feb 2019

Mouse Model News and Research

Altering gut microbiome may be potential treatment option for PCOS

Nervous system relies on guidance cues for neuronal axons to reach destinations

City of Hope exhibits current studies and data on cancer therapies at AACR

Enzyme inhibitor stops inflammation and neurodevelopmental disorders in mouse models

Cholesterol lowering drug can also help treat cancer-associated cachexia

GARP protein can be a potential target for immunotherapy against colorectal cancer

Compounds found in coffee may inhibit growth of prostate cancer

Exosomes are key to SOS signal that the heart muscle sends out after heart attack, study reveals

Study suggests new approach to ameliorating obesity-associated metabolic abnormalities

Increased stress hormones accelerate breast cancer metastasis

Researchers define pathway that helps us make antibodies

Avocado seed extract could be potential source for novel anti-inflammatory compounds

Researchers identify potential therapeutic target for blocking early atherosclerosis in progeria

CMV airway infection enlarges spectrum of environmental allergens

Novel mouse model confirms how “good” and “bad” bacteria affect human acne

Common fungus found on skin may cause inflammatory bowel disease

Aging and high-fat diet disrupt gut microbiome to cause inflammation in heart failure

Research identifies super-enhancers as novel target for pancreatic ductal adenocarcinoma

Scientists find clue to rapid human conversations in singing mice

New study explores stem cells to gain insight into rotator cuff disease

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