$150,000 grant will support research on spinal muscular atrophy

Cure SMA recently awarded a $150,000 research grant to Laxman Gangwani, Ph.D., associate professor of Molecular and Translational Medicine, Center of Emphasis in Neurosciences, at TTUHSC El Paso's Paul L. Foster School of Medicine. The grant will support Gangwani's research on a genetic disorder known as spinal muscular atrophy (SMA).

SMA is caused by a gene mutation that stops the production of a protein critical to the nerves that control muscles. Without the protein, the nerve cells die, leading to debilitating, and often fatal, muscle weakness. There are four types of SMA, and under the most severe form, Type 1, a child cannot hold their neck up or sit, and life expectancy is only approximately two years.

Gangwani's research project, "Function of Senataxin as a Protective Modifier of Spinal Muscular Atrophy," will study a human protein called senataxin that in very preliminary work appears to be able to rescue SMA motor neurons and prevent their degeneration. If the new research can show a positive role for senataxin in a mouse model of SMA, then it would suggest a potential use for senataxin as a therapeutic target in humans, Gangwani said.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News-Medical.Net.
Post a new comment
Post
You might also like... ×
Fatty foods increase CBD absorption, finds new research