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Mount Sinai Health System researchers present updates on cancer vaccine clinical trials at ASCO 2015

Mount Sinai Health System faculty will be presenting research updates on a lymphoma vaccine clinical trial, the best dosing for a drug against metastatic cancer, and new treatment strategies in relapsed multiple myeloma at the American Society of Clinical Oncology annual meeting, May 29 - June 2, 2015, in Chicago.

2 Jun 2015

SIRFLOX study promises better and earlier treatment option for liver cancer patients

The benefits of adding liver-directed SIR-Spheres Y-90 resin microspheres to a current systemic chemotherapy for the first-line treatment of unresectable metastatic colorectal cancer (mCRC) reported in the SIRFLOX study, were presented at the American Society of Clinical Oncology Annual Meeting in Chicago.

2 Jun 2015

TDF alone may be sufficient maintenance in chronic HBV patients

Tenofovir disoproxil fumarate monotherapy may be sufficient to maintain complete virological suppression in patients with chronic hepatitis B virus infection previously treated with TDF plus entecavir, suggests a review of patients.

1 Jun 2015

Meta-analysis sheds light on effectiveness of chronic HBV treatments

A meta-analysis of treatments for chronic hepatitis B virus infection suggests that tenofovir disoproxil fumarate is the most effective option for patients positive and negative for hepatitis B e antigen, but the latter group may also benefit from entecavir treatment.

1 Jun 2015

Modified poliovirus therapy for glioblastoma works best at a low dosage

A modified poliovirus therapy that is showing promising results for patients with glioblastoma brain tumors works best at a low dosage, according to the research team at Duke's Preston Robert Tisch Brain Tumor Center where the investigational therapy is being pioneered.

1 Jun 2015

PanCuRx initiative to reduce pancreatic cancer fatality rate receives $4.6 million investment from OICR

Dr. Tom Hudson, President and Scientific Director of the Ontario Institute for Cancer Research (OICR) today announced OICR is investing $4.6 million over two years in PanCuRx, an initiative that seeks solutions to the high fatality rate of pancreatic cancer.

1 Jun 2015

Simple one-hour therapy session cures 73% of people suffering from acute insomnia

A simple one-hour therapy session has helped to cure 73% of people suffering from acute insomnia, according to a new study from Northumbria University released today.

1 Jun 2015

University of Southampton and BioInvent enter collaboration to develop new cancer immunotherapies

Leading antibody researchers at the University of Southampton, under the direction of Professor Mark Cragg, Professor of Experimental Cancer Research and Director of the Cancer Pathway Integrated Postgraduate Programme, today announce a three-year research collaboration with BioInvent International.

1 Jun 2015

Caris Life Sciences: Study identifies benefit of targeted therapy in CRC with high microsatellite instability

Caris Life Sciences, a leading biotechnology company focused on fulfilling the promise of precision medicine, today announced the results of a study identifying the clinical benefit of targeted therapy in colorectal cancer (CRC) with high microsatellite instability (MSI-H), a predisposition that occurs in 15% of all CRCs causing significantly different prognosis and response to treatment.

1 Jun 2015

Pharmacyclics's Phase III RESONATE™ trial shows adherence to 420mg dose of IMBRUVICA improves outcomes in CLL patients

Pharmacyclics LLC today highlighted results from a sub-analysis of the Phase III RESONATE™ (PCYC-1112) trial, which found that previously-treated patients with chronic lymphocytic leukemia (CLL) who adhered to the recommended 420 mg dose of IMBRUVICA® (ibrutinib) experienced improved progression-free survival (PFS; the primary endpoint) as assessed by an Independent Review Committee (IRC), compared to patients who took lower doses or missed doses, regardless of high-risk genetic factors.

1 Jun 2015

Lenvatinib-everolimus combination extends PFS in patients with mRCC versus everolimus alone

Eisai Inc. announced today results from an investigational Phase 2 trial which showed that lenvatinib, when used in combination with everolimus, significantly extended progression-free survival (PFS) in patients with metastatic renal cell carcinoma (mRCC) versus everolimus alone.

1 Jun 2015

Halozyme announces positive Phase 2 results of PEGPH20 drug for treating metastatic pancreatic cancer patients

Halozyme Therapeutics, Inc., a biotechnology company developing novel oncology and drug-delivery therapies, today announced interim findings from the ongoing phase 2 clinical study of its investigational new drug PEGPH20 for the potential treatment of patients with metastatic pancreatic cancer.

1 Jun 2015

Pharmacyclics’ Ibrutinib Phase Ib/II data show ibrutinib may be safe and effective in patients with cGVHD

Pharmacyclics LLC today announced interim results from the ongoing Phase Ib/II PCYC-1129 study suggesting that ibrutinib (IMBRUVICA) may be a safe and effective treatment for patients with chronic graft-versus-host-disease (cGVHD) who were either refractory to steroid treatment or were steroid-dependent.

1 Jun 2015

WBRT associated with worse cognitive function than radiosurgery, shows study

Whole Brain Radiation Therapy (WBRT) is associated with significantly worse cognitive function than radiosurgery, and should no longer be used in the adjuvant setting after radiosurgery to treat cancer patients with brain metastases, according to a large study led by a researcher at The University of Texas MD Anderson Cancer Center.

1 Jun 2015

PharmaEngine files NDA with Taiwan FDA for MM-398 to treat post-gemcitabine metastatic pancreatic cancer

PharmaEngine, Inc. today announced that a New Drug Application (NDA) has been submitted to the Taiwan Food and Drug Administration (TFDA) for MM-398 (irinotecan liposome injection, also known as nal-IRI) in patients with metastatic adenocarcinoma of the pancreas who have been previously treated with gemcitabine-based therapy.

1 Jun 2015

RI-MUHC researchers receive innovations grants to build technologies to address cancer challenges

"Thanks to the Innovation Fund, our donors to the MGH Foundation and the vision of the Max Pacioretty Foundation, this new specialized MRI will place the Montreal General Hospital as one of the leading level 1 trauma centres in Canada. This valuable piece of healthcare technology will also allow our world-class researchers to better understand brain injuries, which will lead to improved patient diagnosis and treatment," adds Jean-Guy Gourdeau, President and Chief Executive Officer of the Montreal General Hospital Foundation at the MUHC.

1 Jun 2015

ASCO 2015: UH Seidman Cancer Center researchers present data from several new studies

Researchers from University Hospitals Case Medical Center Seidman Cancer Center and Case Western Reserve University School of Medicine will present data from several new studies, including a study evaluating a potential novel combination treatment for cancer patients with advanced solid tumors and a first-of-its-kind analysis of gene mutations in small cell lung cancer (SCLC), at the 51st American Society for Clinical Oncology (ASCO) Annual Meeting in Chicago.

1 Jun 2015

Cleveland Clinic Children's to host second annual Pediatric Innovation Summit

Cleveland Clinic Children's will host its second annual Pediatric Innovation Summit June 11 to 13, 2015, at the Global Center for Health Innovation in Cleveland. Designed to promote the professional development of physicians and healthcare providers, the event will explore the current state of pediatric care and the cutting-edge medical advancements transforming the research and treatment of childhood diseases.

1 Jun 2015

Statins reduce risk of death by 67% in CABG surgery

Research presented at this year's Euroanaesthesia exploring the protective effect of various heart medications that patients are taking before undergoing coronary artery bypass graft (CABG) surgery concludes that statins reduce the risk of death by two thirds, or 67 percent, while no consistent effects were seen for other medications.

1 Jun 2015

International Neuromodulation Society invites media to satellite-event news briefing before 12th World Congress

Representatives of the news media are invited to a satellite-event news briefing at 11 a.m. on June 6, 2015 before the International Neuromodulation Society 12th World Congress in Montreal.

1 Jun 2015

Therapy News and Research

Mount Sinai Health System researchers present updates on cancer vaccine clinical trials at ASCO 2015

SIRFLOX study promises better and earlier treatment option for liver cancer patients

TDF alone may be sufficient maintenance in chronic HBV patients

Meta-analysis sheds light on effectiveness of chronic HBV treatments

Modified poliovirus therapy for glioblastoma works best at a low dosage

PanCuRx initiative to reduce pancreatic cancer fatality rate receives $4.6 million investment from OICR

Simple one-hour therapy session cures 73% of people suffering from acute insomnia

University of Southampton and BioInvent enter collaboration to develop new cancer immunotherapies

Caris Life Sciences: Study identifies benefit of targeted therapy in CRC with high microsatellite instability

Pharmacyclics's Phase III RESONATE™ trial shows adherence to 420mg dose of IMBRUVICA improves outcomes in CLL patients

Lenvatinib-everolimus combination extends PFS in patients with mRCC versus everolimus alone

Halozyme announces positive Phase 2 results of PEGPH20 drug for treating metastatic pancreatic cancer patients

Pharmacyclics’ Ibrutinib Phase Ib/II data show ibrutinib may be safe and effective in patients with cGVHD

WBRT associated with worse cognitive function than radiosurgery, shows study

PharmaEngine files NDA with Taiwan FDA for MM-398 to treat post-gemcitabine metastatic pancreatic cancer

RI-MUHC researchers receive innovations grants to build technologies to address cancer challenges

ASCO 2015: UH Seidman Cancer Center researchers present data from several new studies

Cleveland Clinic Children's to host second annual Pediatric Innovation Summit

Statins reduce risk of death by 67% in CABG surgery

International Neuromodulation Society invites media to satellite-event news briefing before 12th World Congress

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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