Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Researchers unravel how drug interacts with ribosome to halt protein production

The discovery of a chemical compound that halts the production of a small set of proteins while leaving general protein production untouched suggests a new drug search strategy: Find compounds that target undesired proteins before they are even made.

23 Mar 2017

Method used to pick up laboratory mice has major impact on result of mouse studies

A new study shows that how mice are picked up by the experimenter can substantially change their behaviour in cognitive tests. The work, by Dr Kelly Gouveia and Professor Jane Hurst from the University of Liverpool, was published in Scientific Reports today and funded by the NC3Rs .

23 Mar 2017

Mount Sinai researchers review progress made in using ketamine and other therapies to treat depression

Major depressive disorder (MDD) impacts 15 million Americans and is the leading cause of disability, yet current treatments possess limited efficacy.

17 Mar 2017

2017 was another big year for Pittcon, as global attendance and economic impacts are revealed

Pittcon 2017 brought together members from the scientific community from around the world with leading speakers, instructors and exhibiting companies.

From Pittcon 16 Mar 2017

Deep learning in healthcare: a move towards algorithmic doctors

People are constantly trying to find more ‘human’ ways to interact with technology. Could the same be achieved for how we approach our health too?

15 Mar 2017

Virginia Tech researchers move one step closer to understanding heart disease at microscopic level

Researchers are one step closer to understanding heart disease at a microscopic level, a breakthrough that could influence future treatments for millions of people.

7 Mar 2017

Deep learning transforms the drug discovery process in collaboration between Insilico Medicine and Life Extension

In March 2016 Insilico Medicine initiated a research collaboration with Life Extension to apply advanced bioinformatic methods and deep learning algorithms to screen for naturally occurring compounds that may slow down or even reverse the cellular and molecular mechanisms of aging. Today Life Extension (LE) launched a new line of nutraceuticals called GEROPROTECTTM, and the first product in the series called Ageless CellTM combines some of the natural compounds that were shortlisted by Insilico Medicine’s algorithms and are generally recognized as safe (GRAS).

7 Mar 2017

New drug-like compound shows potential to treat symptoms of lupus

Lupus, a chronic autoimmune disease, has proved difficult to treat, but a new international study co-led by a Rush University Medical Center researcher suggests that a drug starting through the pipeline could ameliorate or even eliminate the symptoms in most sufferers.

7 Mar 2017

Sartorius to Acquire Real-Time Live-Cell Analysis Pioneer and Leader Essen BioScience

Sartorius, a leading partner to the biopharmaceutical industry and laboratories, today signed an agreement to acquire U.S. based Essen BioScience Inc.,

From Sartorius 6 Mar 2017

Innovative ways to target antibiotic resistance in short term

There has been much recent talk about how to target the rising tide of antibiotic resistance across the world, one of the biggest threats to global health today.

3 Mar 2017

NovAliX's new laboratory to use cryo-TEM for facilitating small molecule and biologic drug discovery

A new contract research laboratory operated by France-based NovAliX will provide pharmaceutical companies with access to high-resolution cryo-transmission electron microscopy (cryo-TEM) by Thermo Fisher Scientific for facilitating small molecule and biologic drug discovery.

3 Mar 2017

Case Western Reserve and VA team up to tackle rising problem of antibiotic resistance

Since the discovery of penicillin in 1928, antibiotics have made the world a much safer and healthier place. But Shakespeare was onto something when he asked if it's possible to have too much of a good thing. In the case of antibiotics, the answer is increasingly "yes."

3 Mar 2017

Researchers looking at ways to target lingering cancer stem cells that cause disease relapse

Chemotherapy treatment targets and kills cancer cells in the body. However, even after treatment, some cancer cells may remain in the patient's system undetected.

2 Mar 2017

Compound from soil bacteria could translate into new drug lead for TB

A new treatment for tuberculosis (TB) is set to be developed using compounds derived from bacteria that live in soil - according an international collaboration of researchers, including the University of Warwick.

1 Mar 2017

Novel NMR spectroscopy platform holds potential to revolutionize drug development practices

Implementation of a new nuclear magnetic resonance spectroscopy platform will provide professors Nicolas Doucet and Steven LaPlante of Centre INRS-Institut Armand-Frappier with a powerful new tool for conducting an ambitious research program aimed at identifying new therapeutic molecules.

28 Feb 2017

MIT biological engineers develop method to measure heme levels inside malaria parasite

The iron-containing molecule heme is necessary for life. Cells require heme to perform the chemical reactions that produce energy, among other critical tasks.

28 Feb 2017

Princeton-Intel collaboration builds new software to decode brain scans

Early this year, about 30 neuroscientists and computer programmers got together to improve their ability to read the human mind.

24 Feb 2017

Study identifies new role of cholesterol in regulating brain proteins

A study led by researchers at the Hospital del Mar Medical Research Institute and the Institute of Medical Physics and Biophysics at the Faculty of Medicine in Charité Hospital, Berlin, published in the journal Nature Communications, demonstrates that the cholesterol present in cell membranes can interfere with the function of an important brain membrane protein, through a previously unknown mode of interaction.

23 Feb 2017

Chemists discover cheaper, faster way to identify and test new drugs

Chemists at the University of Waterloo, SCIEX and Pfizer have discovered a new way to help the pharmaceutical industry identify and test new drugs, which could revolutionize drug development, and substantially reduce the cost and time drugs need to reach their market.

23 Feb 2017

New approach to generate high volume of hair cells may help restore full hearing

The loss of tiny, sound-sensing cells in the inner ear, known as "hair cells," is a leading cause of hearing loss, a public health problem affecting at least 5 percent of the world population.

22 Feb 2017

Drug Discovery News and Research

Further Reading

Researchers unravel how drug interacts with ribosome to halt protein production

Method used to pick up laboratory mice has major impact on result of mouse studies

Mount Sinai researchers review progress made in using ketamine and other therapies to treat depression

2017 was another big year for Pittcon, as global attendance and economic impacts are revealed

Deep learning in healthcare: a move towards algorithmic doctors

Virginia Tech researchers move one step closer to understanding heart disease at microscopic level

Deep learning transforms the drug discovery process in collaboration between Insilico Medicine and Life Extension

New drug-like compound shows potential to treat symptoms of lupus

Sartorius to Acquire Real-Time Live-Cell Analysis Pioneer and Leader Essen BioScience

Innovative ways to target antibiotic resistance in short term

NovAliX's new laboratory to use cryo-TEM for facilitating small molecule and biologic drug discovery

Case Western Reserve and VA team up to tackle rising problem of antibiotic resistance

Researchers looking at ways to target lingering cancer stem cells that cause disease relapse

Compound from soil bacteria could translate into new drug lead for TB

Novel NMR spectroscopy platform holds potential to revolutionize drug development practices

MIT biological engineers develop method to measure heme levels inside malaria parasite

Princeton-Intel collaboration builds new software to decode brain scans

Study identifies new role of cholesterol in regulating brain proteins

Chemists discover cheaper, faster way to identify and test new drugs

New approach to generate high volume of hair cells may help restore full hearing

ELRIG Drug Discovery: Poster Sessions eBook

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