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Study reveals new clues to the underlying cause of FXS symptoms

In Fragile X syndrome (FXS), the most common cause of autism, sensory signals from the outside world are integrated differently, causing them to be underrepresented by cortical pyramidal neurons in the brain.

17 Feb 2023

Scientists discover how a "poisoned" form of protein could spur cancer formation

Scientists at Scripps Research, with collaborators in Japan, have discovered how a "poisoned" form of a protein could set off a cascade of events that encourage the growth of some cancers.

17 Feb 2023

An oral and on-demand male contraceptive

Researchers identify a soluble adenylyl cyclase (sAC) inhibitor that has the potential to be used as an on-demand oral contraceptive for men.

16 Feb 2023

Small molecule inhibitor reverses malignant hyper-editing by an inflammation-induced protein isoform

Researchers at University of California San Diego School of Medicine, Sanford Stem Cell Institute and Moores Cancer Center report that a late-stage, pre-clinical small molecule inhibitor, called rebecsinib, reverses malignant hyper-editing by an inflammation-induced protein isoform, known as ADAR1 p150.

16 Feb 2023

Repurposing or improving drugs for spinocerebellar ataxia type 5

A team of researchers has developed a new method to screen FDA-approved drugs to determine if they could be repurposed or improved to help patients with a rare, debilitating disease of the nervous system.

16 Feb 2023

Electrochemical microsensor enables real-time study of serotonin dynamics in the brain

Dysregulation of serotonin plays a role in many psychiatric disorders, including severe depression and anxiety. In the journal Angewandte Chemie, a research team has now introduced an implantable, electrochemical microsensor that makes it possible to study serotonin dynamics in the brain in real time.

16 Feb 2023

UIC scientists find new way to better target cellular proteins

By studying how enzymes move from one membrane compartment to another inside a cell, scientists at the University of Illinois Chicago have figured out a way to better target cellular proteins, which play a role in many diseases.

15 Feb 2023

Protein degradation approach can be used to hit an ‘undruggable’ target against cancer

The protein STAT5 has long been an appealing target against cancer, but after decades of research it was consigned to the "undruggable" category.

15 Feb 2023

Scientific breakthrough by Sjöberg laureate brings new hope to lung cancer patients

This year's Sjöberg Prize in cancer research of one million dollars is awarded to professor Kevan Shokat, University of California, USA.

15 Feb 2023

Study elucidates how cannabidiol reduces seizures in treatment-resistant pediatric epilepsy

A study reveals a previously unknown way in which cannabidiol (CBD), a substance found in cannabis, reduces seizures in many treatment-resistant forms of pediatric epilepsy.

13 Feb 2023

New analytical platform quantifies the structure of mRNA-based medicines

Researchers from Tokyo Metropolitan University and RIKEN CSRS have developed a new analytical platform based on liquid chromatography, mass spectrometry and software analysis that quantifies the structure of messenger RNA (mRNA) based medicines.

13 Feb 2023

Molecular switch regulates autophagy in plants

Autophagy, or "self-eating", is an essential cellular quality control mechanism that clears the cell of protein aggregates and damaged organelles. This mechanism is inactive under normal conditions and only triggered upon persistent cellular stress.

10 Feb 2023

New abiotic pathway discovered for the formation of peptide chains from amino acids

A team of scientists from France and Austria has discovered a new abiotic pathway for the formation of peptide chains from amino acids - a key chemical step in the origin of life.

10 Feb 2023

Disruptions to the normal fllow of brain fluid linked to neurological conditions

The brain floats in a sea of fluid that cushions it against injury, supplies it with nutrients and carries away waste.

10 Feb 2023

New compound limits the replication of influenza viruses

Viruses use the molecular repertoire of the host cell to replicate. Researchers from the Cluster of Excellence ImmunoSensation2 at the University of Bonn, together with Japanese researchers, want to exploit this for the treatment of influenza.

9 Feb 2023

Protein activity found to be more dysregulated in the blood of patients with alcohol-associated hepatitis

Biochemist Jon Jacobs has analyzed the blood of patients with diseases and conditions such as Ebola, cancer, tuberculosis, hepatitis, diabetes, Lyme disease, brain injury and influenza.

9 Feb 2023

Researchers discover small molecules that can lock SARS-CoV-2 spike proteins

The infamous spike proteins on the surface of SARS-CoV-2 help it bind to and enter human cells. Because of their important role in spreading infection, these spike proteins are one of the main targets for COVID-19 vaccines and treatments.

9 Feb 2023

A microbiota-driven mechanism underlies severity of leishmaniasis infection

In a recent study posed to the medRxiv* preprint server, researchers in Brazil and the United States investigated the probable impact of the skin microbiome microbiota on the outcomes of cutaneous leishmaniasis.

8 Feb 2023

Newest vitamin B3 family member has beneficial effects on mitochondria in the human muscle

The newest vitamin B3 family member, nicotinamide riboside (NR) has been found to have beneficial effects on mitochondria in the human muscle.

8 Feb 2023

Researchers develop a new method to design peptide antibiotics

Hokkaido University researchers have developed a novel method to design and develop peptide antibiotics in large numbers, which will prove critical to controlling antibiotic resistance.

7 Feb 2023

Molecule News and Research

Study reveals new clues to the underlying cause of FXS symptoms

Scientists discover how a "poisoned" form of protein could spur cancer formation

An oral and on-demand male contraceptive

Small molecule inhibitor reverses malignant hyper-editing by an inflammation-induced protein isoform

Repurposing or improving drugs for spinocerebellar ataxia type 5

Electrochemical microsensor enables real-time study of serotonin dynamics in the brain

UIC scientists find new way to better target cellular proteins

Protein degradation approach can be used to hit an ‘undruggable’ target against cancer

Scientific breakthrough by Sjöberg laureate brings new hope to lung cancer patients

Study elucidates how cannabidiol reduces seizures in treatment-resistant pediatric epilepsy

New analytical platform quantifies the structure of mRNA-based medicines

Molecular switch regulates autophagy in plants

New abiotic pathway discovered for the formation of peptide chains from amino acids

Disruptions to the normal fllow of brain fluid linked to neurological conditions

New compound limits the replication of influenza viruses

Protein activity found to be more dysregulated in the blood of patients with alcohol-associated hepatitis

Researchers discover small molecules that can lock SARS-CoV-2 spike proteins

A microbiota-driven mechanism underlies severity of leishmaniasis infection

Newest vitamin B3 family member has beneficial effects on mitochondria in the human muscle

Researchers develop a new method to design peptide antibiotics

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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