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Benefits and Challenges for XpressAmp™ Direct Amplification Reagents

News-Medical interviews Curtis Knox, Sr Strategic Portfolio Manager at Promega, about using the XpressAmp™ for the direct amplification of reagents.

From Promega Corporation 15 Jun 2021

The Native Antigen Company wins ‘The Best COVID-19 Responder’ at OBN 2020 Awards

The Native Antigen Company, part of LGC Clinical Diagnostics, won ‘The Best COVID-19 Responder’ at OBN 2020 Awards.

From The Native Antigen Company 14 Jun 2021

Humoral innate pattern recognition molecules against SARS-CoV-2

In a paper recently uploaded to the preprint server medRxiv by Garlanda et al. (June 8th, 2021), humoral pattern recognition molecules are explored for affinity towards SARS-CoV-2, contributing to unraveling the role of these molecules in COVID-19 disease progression.

13 Jun 2021

Scientists detect delayed and reduced antibody responses after BioNTech/Pfizer COVID-19 vaccination in older adults

Researchers at the U.S. Centers for Disease Control and Prevention (CDC) detected delayed and reduced antibody and T cell responses after immunization with BNT162b2 or the Pfizer-BioNTech COVID-19 vaccine in older adults compared with healthcare workers in Germany.

11 Jun 2021

Rapid Point-of-Care Testing Using Screen-Printed Electrodes from Metrohm DropSens

Point-of-care (POC) testing with screen-printed electrodes allows rapid testing of populations for viral outbreaks – at affordable costs, without the need for trained specialists and/or complicated equipment.

From Metrohm Middle East FZC 11 Jun 2021

Innovative protocol that processes saliva samples before testing may improve COVID-19 detection

The collection of nasopharyngeal swab (NPS) samples for COVID-19 diagnostic testing poses challenges including exposure risk to healthcare workers and supply chain constraints. Saliva samples are easier to collect but can be mixed with mucus or blood, and some studies have found they produce less accurate results.

10 Jun 2021

Bovine-derived polyclonal antibodies exhibit high efficacy in neutralizing SARS-CoV-2 variants

A team of scientists in Estonia has recently evaluated the therapeutic/prophylactic efficacy of anti-SARS-CoV-2 polyclonal antibodies derived from the colostrum of immunized cows.

10 Jun 2021

Local anesthetic procaine inhibits SARS-CoV-2 in vitro

Research has shown that procaine and procaine-hydrochloride can reduce replication of SARS-CoV-2 and influenza A viruses in infected cells and reduce the production of cytokines by the viruses, making them potentially useful for treating COVID-19.

10 Jun 2021

Trained dogs can accurately identify COVID-19 by scent

An interesting new medRxiv* preprint reveals that with careful training, the exquisite scent sensitivity of dogs may be exploited to rule out the presence of coronavirus disease 2019 (COVID-19) in human beings in real-time.

9 Jun 2021

Structural analogs of triterpenoids show strong inhibitory activity against coronaviruses

In a recent study published in the journal Pathogens, researchers carried out a molecular docking study for 17 structural analogs prepared from natural maslinic and oleanolic acids and screened them against SARS-CoV-2 main protease. They also experimentally validated the data by determining the half-maximal cytotoxic and inhibitory concentrations of each of the 17 compounds. The researchers investigated whether the compound with antiviral activity affected viral adsorption, replication, or viricidal effect using a plaque infectivity reduction assay.

9 Jun 2021

SARS-CoV-2 immunity persists for up to 11 months after natural infection

The study, published in the Journal of Infectious Diseases, determined how circulating antibody levels change after being infected with SARS-CoV-2.

8 Jun 2021

MIT researchers develop a molecular assay to detect sub-picomolar levels of the SARS-CoV-2's receptor-binding domain

A team of researchers at MIT has developed a molecular assay to detect sub-picomolar levels of the SARS-CoV-2’s spike protein receptor-binding domain (S-RBD) using computationally validated peptide beacons in a single-step detection through the production of a fluorescence signal.

8 Jun 2021

Nanozymes to the rescue - potential role in fighting COVID-19

Over the last few decades, researchers have developed artificial enzymes for many applications. Recently, they deployed nanomaterial-based enzyme mimetics or nanozymes in diagnosis and therapeutics. Nanozymes find applications in various biomedical applications, including antiviral agents and cancer therapy.

8 Jun 2021

Immunomodulatory therapies for nephrological autoimmune diseases may help treat severe COVID-19

Various viruses and bacteria have long been known to cause autoimmune diseases where there is such a predisposition. This phenomenon also seems to play a major role in SARS-CoV-2, especially in severe courses.

8 Jun 2021

NIH researchers identify novel small molecule inhibitors of SARS-CoV-2 variants

A team of scientists from the National Institutes of Health (NIH), USA, has recently identified six novel small molecule inhibitors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants. The study is currently available on the bioRxiv* preprint server.

8 Jun 2021

Fluorescence-based assay for detecting SARS-CoV-2 neutralizing antibodies

Researchers have developed a rapid assay to rapidly detect neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using an imaging technique they developed for the Ebola virus.

8 Jun 2021

Study observes broad and invariable memory B cell response following SARS-CoV-2 infection

A new study by researchers at the Oregon Health & Science University (OHSU) in the USA goes far in answering this question by showing the presence of memory B cells that react to the original SARS-CoV-2 as well as VOCs.

7 Jun 2021

Seroprevalence study of SARS-CoV-2 infection in domestic cats

To monitor the occurrence of trans-species transmission, researchers from the Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Germany, conducted a survey of seroprevalence in domestic cats.

7 Jun 2021

Beckman Coulter launches new Access AMH Advanced assay to predict poor ovarian response

Beckman Coulter, a global leader in diagnostics and infertility testing, announced today the launch of the first and only test that uses a validated cut-off to aid in the assessment of ovarian response.

7 Jun 2021

High baseline levels of inflammatory cytokines linked to thrombotic events in patients with COVID-19

In a recent open-access paper published in the Journal of Clinical Medicine, researchers from Iran and Germany show that high baseline levels of inflammatory cytokines measured during admission put patients with coronavirus disease (COVID-19) at increased risk of developing coagulopathy, thrombotic events – and even death.

6 Jun 2021

Assay News and Research

Benefits and Challenges for XpressAmp™ Direct Amplification Reagents

The Native Antigen Company wins ‘The Best COVID-19 Responder’ at OBN 2020 Awards

Humoral innate pattern recognition molecules against SARS-CoV-2

Scientists detect delayed and reduced antibody responses after BioNTech/Pfizer COVID-19 vaccination in older adults

Rapid Point-of-Care Testing Using Screen-Printed Electrodes from Metrohm DropSens

Innovative protocol that processes saliva samples before testing may improve COVID-19 detection

Bovine-derived polyclonal antibodies exhibit high efficacy in neutralizing SARS-CoV-2 variants

Local anesthetic procaine inhibits SARS-CoV-2 in vitro

Trained dogs can accurately identify COVID-19 by scent

Structural analogs of triterpenoids show strong inhibitory activity against coronaviruses

SARS-CoV-2 immunity persists for up to 11 months after natural infection

MIT researchers develop a molecular assay to detect sub-picomolar levels of the SARS-CoV-2's receptor-binding domain

Nanozymes to the rescue - potential role in fighting COVID-19

Immunomodulatory therapies for nephrological autoimmune diseases may help treat severe COVID-19

NIH researchers identify novel small molecule inhibitors of SARS-CoV-2 variants

Fluorescence-based assay for detecting SARS-CoV-2 neutralizing antibodies

Study observes broad and invariable memory B cell response following SARS-CoV-2 infection

Seroprevalence study of SARS-CoV-2 infection in domestic cats

Beckman Coulter launches new Access AMH Advanced assay to predict poor ovarian response

High baseline levels of inflammatory cytokines linked to thrombotic events in patients with COVID-19

Measuring Drug-Target Residence Times with Biochemical Assays eBook

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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