Immune System News and Research

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Expecting enough bird flu vaccine for everyone is a big ask

According to researchers an experimental vaccine produced to offer protection against the H5N1 strain of bird flu presently causing havoc across the world, only appears to work at the very highest doses.

31 Mar 2006

GlaxoSmithKline announces start of clinical trials to test two pandemic vaccines against the H5N1

GlaxoSmithKline has announced the start of an international clinical trial program to test two pandemic vaccines against the H5N1 strain of the avian influenza virus in humans. This dual approach reflects the company's commitment to provide health authorities with concrete options to face the threat of a pandemic.

30 Mar 2006

Inducing melanoma for cancer vaccine development

Cancer vaccines are being investigated in early-phase clinical trials around the world, with many of those trials recruiting patients with melanoma.

28 Mar 2006

Novel therapy for chronic graft-versus-host disease

A study by Dana-Farber Cancer Institute researchers offers the strongest evidence yet of the effectiveness of a novel therapy for chronic graft-versus-host disease (GVHD), a potentially life-threatening complication of donor bone marrow and stem cell transplants.

28 Mar 2006

Study on fruit flies offers new approach to understand human response to viral infections

A research team led by UC Riverside scientists has shown that the common fruit fly can serve as an excellent model for studying the immunity animals are born with for fighting viral infections.

28 Mar 2006

New way of targeting proteins to exosomes - potential for melanoma, Alzheimer's disease

Researchers at the University of Pennsylvania School of Medicine have discovered how a protein called Pmel17 is sorted by pigment cells in the skin and eye to make a fiber matrix that eventually sequesters melanin, the dark pigment found in skin, hair, and eyes.

28 Mar 2006

First trial to combine a biologic agent with a conventional chemotherapy agent for the treatment of ovarian cancer

Researchers found the addition of thalidomide to topotecan for the treatment of recurrent ovarian cancer significantly increases the response to therapy and the duration of progression free survival without additional toxicity.

28 Mar 2006

Discovery of a gene that drives anthrax bacteria's toxic effects

A study in Cell reports the discovery of a gene that drives anthrax bacteria's toxic effects. The gene could offer a potential new target for countermeasures against the lethal toxin, according to the researchers.

28 Mar 2006

RNAi-based inhibitors for created for nearly every human and mouse gene - available to all genetic researchers

An international public-private research team led by scientists at the Broad Institute of MIT and Harvard announced today the construction and availability of an extensive library of molecular reagents to silence most human and mouse genes.

28 Mar 2006

Procedure cures some diabetic mice, but not in the way previously reported

Researchers attempting to reproduce a controversial 2003 mouse experiment suggestive of a cure for type 1 diabetes have found evidence that the experimental procedure does eliminate diabetic symptoms in a small fraction of the mice exposed to it.

28 Mar 2006

Researchers find compound 10 times more effective than isoniazid, the leading anti-tuberculosis drug

Researchers at the Albert Einstein College of Medicine of Yeshiva University have synthesized chemicals that are up to 10 times more effective than isoniazid, the leading anti-tuberculosis drug.

28 Mar 2006

Study provides a boost for efforts to reverse type-1 diabetes

Researchers have been able to confirm most but not all of the results of a high-profile study that brought new hope to diabetes patients. This study provides a boost for efforts to reverse type-1 diabetes in recently diagnosed patients but not for efforts to grow new islets from spleens.

27 Mar 2006

Gene therapy treatment for brain tumours and infections

In a study published in the March 15 issue of The Journal of Immunology, researchers at Board of Governors' Gene Therapeutics Research Institute at Cedars-Sinai Medical Center have developed a way to overcome immune privilege in the brain to eradicate potentially deadly brain tumors such as glioblastoma multiforme and other types of brain infections.

27 Mar 2006

Novel therapy for chronic graft-versus-host disease (GVHD) using Rituximab

Dana-Farber researchers found that rituximab reduced the severity of chronic graft-versus-host disease (GVHD) in 70 percent of the study participants.

27 Mar 2006

Marital strain appears to matter for health as individuals age

Researchers have found that marital strain accelerates the typical decline in self-rated physical health that occurs over time and that this adverse effect is greater at older ages.

27 Mar 2006

Phagocytosis depends more on particle shape than size

The research, which has far-reaching implications for immunology, vaccine development and drug delivery, is published today online in the Proceedings of the National Academy of Sciences by Samir Mitragotri, a UCSB professor of chemical engineering, and graduate student Julie A. Champion. The paper will be published in print on March 28.

23 Mar 2006

Remicade (infliximab) gains Australian approval for treatment of early rheumatoid arthritis

Schering-Plough Corporation today announced that the Therapeutic Goods Administration of the Department of Health and Ageing in Australia has revised the indication of Remicade (infliximab) to include the treatment of early rheumatoid arthritis (RA) and approved a new indication for psoriatic arthritis (PsA).

23 Mar 2006

Researchers combat tuberculosis - help may come from protective protein

Most Americans think of tuberculosis as a disease of the past, but with HIV and drug-resistant strains fueling epidemics in India and Africa, TB kills someone every six seconds across the world.

23 Mar 2006

Zinc's role in Alzheimer's disease

Zinc may be a familiar dietary supplement to millions of health-conscious people, but it remains a mystery metal to scientists who study zinc's role in Alzheimer's disease, stroke and other health problems.

23 Mar 2006

Immune system protein LL-37 critical in controlling replication of vaccinia virus

Scientists supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), have identified a defect in the immune response of people with the skin condition atopic dermatitis that puts them at risk of developing serious complications following smallpox vaccination.

23 Mar 2006

Immune System News and Research

Expecting enough bird flu vaccine for everyone is a big ask

GlaxoSmithKline announces start of clinical trials to test two pandemic vaccines against the H5N1

Inducing melanoma for cancer vaccine development

Novel therapy for chronic graft-versus-host disease

Study on fruit flies offers new approach to understand human response to viral infections

New way of targeting proteins to exosomes - potential for melanoma, Alzheimer's disease

First trial to combine a biologic agent with a conventional chemotherapy agent for the treatment of ovarian cancer

Discovery of a gene that drives anthrax bacteria's toxic effects

RNAi-based inhibitors for created for nearly every human and mouse gene - available to all genetic researchers

Procedure cures some diabetic mice, but not in the way previously reported

Researchers find compound 10 times more effective than isoniazid, the leading anti-tuberculosis drug

Study provides a boost for efforts to reverse type-1 diabetes

Gene therapy treatment for brain tumours and infections

Novel therapy for chronic graft-versus-host disease (GVHD) using Rituximab

Marital strain appears to matter for health as individuals age

Phagocytosis depends more on particle shape than size

Remicade (infliximab) gains Australian approval for treatment of early rheumatoid arthritis

Researchers combat tuberculosis - help may come from protective protein

Zinc's role in Alzheimer's disease

Immune system protein LL-37 critical in controlling replication of vaccinia virus

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