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Agreement to explore Optimer vehicles for targeted delivery of siRNA

New collaboration will evaluate Aptamer’s fibrotic liver delivery vehicles with siRNA.

From Aptamer Group 9 Jul 2024

Innovative HIV vaccine approaches yield potential for broad protection against viral strains

A major challenge in developing a vaccine for HIV is that the virus mutates fast - very fast. Although a person initially becomes infected with one or a few HIV strains, the virus replicates and mutates quickly, resulting in a "swarm" of viral strains existing in a single body.

2 Jul 2024

Study finds promising new target for the treatment of Alzheimer's disease

A class of proteins that regulates cell repair and enhances cell growth-signaling systems could be a promising new target for the treatment of Alzheimer's and other neurodegenerative diseases, according to a new study led by researchers at Penn State.

2 Jul 2024

Researchers identify key osteoporosis-related gene and develop new mouse model of the disease

Osteoporosis - weakening of the bones with age - affects millions worldwide, and this figure is increasing annually as the global population ages.

1 Jul 2024

Serotonin 2C receptor in the brain regulates memory in people and animal models, research shows

Researchers at Baylor College of Medicine, the University of Cambridge in the U.K. and collaborating institutions have shown that serotonin 2C receptor in the brain regulates memory in people and animal models.

28 Jun 2024

Researchers identify key players in abnormal bone differentiation

A study conducted by researchers at Baylor College of Medicine and collaborating institutions reveals the molecular events leading to osteogenesis imperfecta type V, a form of brittle bone disease caused by a mutation in the gene IFITM5.

27 Jun 2024

Designing hybrid antibodies with enhanced mobility and signaling capacity

Antibodies are the body's superheroes, recognizing and eliminating disease-causing substances.

25 Jun 2024

Advances in organoids and embryonic models pose no risk to personhood, expert argues

Advances in organoids and embryonic models of human development have the potential to prompt social and existential questions - e.g., what defines human individuality? However, bioethicist Insoo Hyun of Harvard Medical School and the Museum of Science in Boston says that these models have the potential to strengthen rather than weaken the concept of human individuality when considered within the philosophical frameworks of "personhood" and sentience.

20 Jun 2024

Yeast-fermented bread shows promise in preventing asthma symptoms

The effects of a functional bread fermented with yeast (Saccharomyces cerevisiae) in asthma prevention.

20 Jun 2024

New therapeutic approach for Duchenne muscular dystrophy combines LED therapy with idebenone

In an animal model of Duchenne muscular dystrophy, Brazilian researchers tested a therapy that combines photobiomodulation using laser light or light-emitting diodes (LEDs) with idebenone, an antioxidant compound investigated for application in neurodegenerative diseases.

14 Jun 2024

How increased mTOR activity shortens lifespan and promotes aging-related diseases

The reality of a population who is aging at an accelerated rate makes it a priority to understand what happens in the body over time, on a molecular scale.

7 Jun 2024

Blocking CDK7 protein could prevent heart damage associated with cancer treatment

Blocking a protein known as CDK7 could prevent heart damage associated with a commonly used cancer chemotherapy medication, according to a study led by scientists at Washington State University.

4 Jun 2024

Female and male heart failure may require distinct treatments

A new study from the UC Davis School of Medicine found striking differences at the cellular level between male and female mice with heart failure with preserved ejection fraction (HFpEF).

30 May 2024

New optogenetics approach may offer better muscle control with less fatigue

For people with paralysis or amputation, neuroprosthetic systems that artificially stimulate muscle contraction with electrical current can help them regain limb function.

23 May 2024

Improved animal model captures full picture of periodontal disease progression

Periodontal disease, represented by periodontitis, is the leading cause of tooth loss and affects close to one in five adults worldwide.

22 May 2024

Understanding the role of oxidative stress in Alzheimer's disease pathogenesis

The number of people suffering from Alzheimer's disease (AD) is expected to reach 100 million by 2050, but there is still no effective therapy.

21 May 2024

World's first human mini-brain with a fully functional blood-brain barrier developed

In a pioneering achievement, a research team led by experts at Cincinnati Children's have developed the world's first human mini-brain that incorporates a fully functional blood-brain barrier (BBB).

20 May 2024

Non-viral gene therapy offers hope for chronic low back pain sufferers

A novel non-viral gene therapy for discogenic back pain (DBP).

20 May 2024

Study proposes a novel therapeutic avenue for tackling EHF-induced cholangiocarcinogenesis

This study is led by Dr. Yiming Luo (Hepatic Surgery Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology) and Professor. Huifang Liang (Hepatic Surgery Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology).

14 May 2024

Breakthrough research offers promise for developing new immune therapies for cancer

Scientists from Trinity College Dublin have made an important breakthrough that offers promise for developing new immune therapies for cancer.

9 May 2024