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New marker identifies the functional maturity and heterogeneity of stem cell–derived islet organoids

Over 500 million people worldwide suffer from diabetes-a disease that contributes to major complications such as stroke, kidney failure, cancer, and Alzheimer's disease.

4 Jun 2025

Early camizestrant therapy keeps advanced breast cancer in check

Switching to camizestrant, a next-generation oral SERD, significantly prolongs progression-free survival and maintains quality of life in patients with ESR1-mutated, hormone receptor-positive advanced breast cancer. The proactive, biomarker-guided approach allows earlier intervention and may redefine standard care.

3 Jun 2025

How soy and gut microbes alter cancer treatment results

Researchers have discovered that plant-derived phytochemicals and their gut microbiome metabolites control the effectiveness of PI3K inhibitors in cancer therapy. The study reveals that dietary components, especially soy compounds processed by gut bacteria, can alter drug metabolism and impact treatment outcomes.

2 Jun 2025

What drives insulin resistance? Proteomics reveals key pathways in human skeletal muscle

Identifying proteomic signatures of insulin resistance in fasting muscle offers insights for personalized type 2 diabetes therapies based on molecular profiles.

30 May 2025

Early allergen introduction reduces childhood food allergy risk

Investigating allergy prevention, this research highlights early intervention strategies and the promise of biologic treatments in managing allergic conditions.

29 May 2025

Nuclera and Cytiva collaborate to accelerate characterization of proteins for drug development

Nuclera, the biotechnology company accelerating protein expression and optimization through its benchtop eProtein Discovery™ System, has announced a collaboration with Cytiva, a global life sciences leader.

28 May 2025

Advancing GPCR drug discovery with fragment screening using GCI technology

Evotec's insights into GPCRs and waveRAPID technology reveal new opportunities in drug discovery, focusing on orphan receptors and innovative screening methods.

From Creoptix (A Malvern Panalytical brand) 23 May 2025

Natural compounds from Brazilian plants show promise against stomach cancer

A new review was published in Volume 12 of Oncoscience on May 8, 2025, titled "The chemopreventive effects of native Brazilian plants on stomach cancer: A review of the last 25 years."

22 May 2025

Gut bacteria and diet found to affect cancer treatment outcomes

A Ludwig Cancer Research study has uncovered a surprising link between diet, intestinal microbes and the efficacy of cancer therapy.

22 May 2025

NELL2 identified as a key regulator of bone formation and fat suppression

A recent study identifies Neural EGFL-like 2 (NELL2), a secreted protein, as a key regulator of bone homeostasis, offering potential therapeutic applications for osteoporosis.

19 May 2025

Inhaled microplastics suppress pulmonary macrophages critical to the immune system

Microplastics are ubiquitous in the environment, and we all routinely inhale these tiny pollutants. Now new research published at the ATS 2025 International Conference has found that inhaled microplastics suppress pulmonary macrophages, a type of white blood cell found in the lungs that are critical to the immune system.

19 May 2025

Common anti-inflammatory drugs may aid virus spread

New research shows an unintended and unfortunate side effect of common drugs. They can simply help viruses spread.

19 May 2025

Evolution of malaria protein family offers new drug targets

Researchers from the Francis Crick Institute and the Gulbenkian Institute for Molecular Medicine (GIMM) have shown that the evolution of a family of exported proteins in the malaria-causing parasite Plasmodium falciparum enabled it to infect humans.

19 May 2025

Long noncoding RNA ESSENCE identified as key driver of colorectal cancer progression

Colorectal cancer (CRC) remains one of the most prevalent and deadly cancers worldwide, with rising incidence linked to dietary and lifestyle changes.

18 May 2025

HER3 reemerges as a key driver of cancer progression and therapy resistance

A new publication shines a spotlight on HER3, a long-overlooked member of the ErbB receptor family, revealing its critical role in cancer progression and resistance to therapy.

12 May 2025

Precision nano therapy targets tumor nerves in pancreatic cancer

Announcing a new publication for Acta Materia Medica journal. A preclinical study has developed a precision nano-intervention strategy targeting tumor-associated nerves to destroy nerve-fueled tumor growth in pancreatic cancer.

8 May 2025

Obicetrapib slashes LDL cholesterol by over 30% in high-risk heart patients

A large multinational trial published in the New England Journal of Medicine shows that obicetrapib significantly lowers LDL cholesterol in high-risk cardiovascular patients. The CETP inhibitor also improved key lipid parameters with no major safety concerns, supporting its role in future combination therapies.

8 May 2025

Study reveals potential new strategy to prevent or slow progression of Type 1 diabetes

A study co-led by Indiana University School of Medicine researchers presents a potential new strategy to prevent or slow the progression of Type 1 diabetes by targeting an inflammation-related protein known to drive the disease.

7 May 2025

Precision medicine approach improves treatment for soft tissue sarcomas

A study conducted by researchers from the Agency for Science, Technology and Research (A*STAR), National Cancer Centre Singapore (NCCS) and National University of Singapore (NUS), in collaboration with biotech company, KYAN Technologies, has demonstrated that a precision medicine approach improves treatment selection for patients with soft tissue sarcomas (STS) in a clinical setting.

7 May 2025