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FDA approval of pembrolizumab marks major shift in head and neck cancer treatment

Pembrolizumab, an immune checkpoint inhibitor, has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of patients with resectable locally advanced head and neck squamous cell carcinoma whose tumors express PD-L1 [Combined Positive Score (CPS) ≥1] as determined by an FDA-approved test.

15 Jun 2025

Prenatal exposure to forever chemicals linked to higher teen blood pressure

Children exposed before birth to synthetic compounds called "forever chemicals" had higher blood pressure during their teenage years, according to new research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association.

13 Jun 2025

Study reveals a unique vulnerability in melanoma patients with neurofibromin 1 mutations

Increased activity in a specific biological pathway may explain why many patients with a deadly form of skin cancer do not respond to the latest cancer treatments, a new study shows.

10 Jun 2025

New non-invasive method boosts the brain's natural waste drainage system

Scientists at the Institute for Basic Science (IBS) have uncovered a non-invasive method to boost the brain's natural waste drainage system-a discovery that could open new avenues for tackling age-related neurological disorders.

4 Jun 2025

Navigating the dual role of B cells in tumor immunity

B lymphocytes exhibit dual roles in tumorigenesis, acting as both allies and adversaries in the tumor microenvironment (TME).

3 Jun 2025

Avelumab and cetuximab combination shows promise in phase II skin cancer trial

A phase II clinical trial led by the Alliance for Clinical Trials in Oncology has met its primary endpoint, demonstrating that the combination of avelumab and cetuximab improved progression-free survival (PFS) compared to avelumab alone in patients with advanced cutaneous squamous cell carcinoma (cSCC).

1 Jun 2025

Combination treatment extends progression-free survival in advanced skin cancer

In patients with an advanced type of skin cancer called cutaneous squamous cell carcinoma (cSCC), those who received the combination of the immunotherapy drug avelumab and targeted agent cetuximab had almost four times longer median progression-free survival compared to patients who received avelumab alone, according to the results of a phase 2 trial presented today at the American Society of Clinical Oncology (ASCO) meeting and concurrently published in the Journal of Clinical Oncology.

1 Jun 2025

TTF1 identified as key biomarker for advanced KRAS G12C-mutated non-small cell lung cancer

Researchers from The University of Texas MD Anderson Cancer Center have identified a new biomarker, TTF-1, that was predictive of survival outcomes for patients with advanced KRAS G12C-mutated non-small cell lung cancer (NSCLC), following treatment with the KRAS targeted therapy sotorasib.

30 May 2025

New plant-derived therapy shows promise for cancer pain relief

RTX is a non-addictive pain therapy derived from a cactus-like plant.

29 May 2025

New clinical practice guideline advances surgical care for chronic rhinosinusitis

The American Academy of Otolaryngology–Head and Neck Surgery Foundation (AAO-HNSF) published the new Clinical Practice Guideline (CPG): Surgical Management of Chronic Rhinosinusitis today in Otolaryngology–Head and Neck Surgery.

27 May 2025

A ministroke can have major consequences

Kristin Kramer woke up early on a Tuesday morning 10 years ago because one of her dogs needed to go out. Then, a couple of odd things happened.

27 May 2025

Vagus nerve stimulation shows unprecedented recovery rates in spinal cord injuries

In a new clinical study, researchers from the Texas Biomedical Device Center (TxBDC) at The University of Texas at Dallas demonstrated unprecedented rates of recovery for spinal cord injuries.

21 May 2025

New blood test detects HPV-linked head and neck cancer with unmatched accuracy

A new liquid biopsy blood test could help detect cases of human papillomavirus (HPV)-associated head and neck cancers with significantly higher accuracy than currently used methods, including before patients develop symptoms, according to new Mass General Brigham research.

20 May 2025

Ubrogepant relieves early migraine symptoms and may help prevent full-blown attacks

A phase 3 trial found that ubrogepant, given during the premonitory phase of migraine, improved common warning symptoms such as fatigue, light and sound sensitivity, and neck pain. These benefits were observed as early as one hour post-treatment, suggesting early intervention can reduce migraine burden.

15 May 2025

Flawed federal programs maroon rural Americans in telehealth blackouts

Ada Carol Adkins lives with her two dogs in a trailer tucked into the timbers off Upper Mud River Road.

14 May 2025

Hearing aids may help older adults combat social isolation

Providing hearing aids and advice on their use may preserve social connections that often wane as we age, a new study shows.

12 May 2025

Millions of women may be unaware of their risk for cardiovascular-kidney-metabolic disease

Millions of women may be unknowingly living with risk factors for heart, kidney and metabolic disease – interconnected conditions that together drive risk for cardiovascular disease, the leading cause of death among women, according to experts with the American Heart Association, a global force changing the future of health for all.

12 May 2025

Annual blood test could detect cancer earlier and save lives

A single blood test, designed to pick up chemical signals indicative of the presence of many different types of cancer, could potentially thwart progression to advanced disease while the malignancy is still at an early stage and amenable to treatment in up to half of cases, suggests a modelling study published in the open access journal BMJ Open.

8 May 2025

Study identifies key enzyme linked to metastasis in head and neck cancer

A recent study published in Engineering has shed new light on the mechanisms underlying the metastasis of head and neck squamous cell carcinoma (HNSCC).

8 May 2025

Immunotherapy before and after surgery boost longer event-free survival in head and neck cancer

Patients with locally advanced head and neck cancer who received the immune checkpoint inhibitor pembrolizumab before, during and after standard-of-care surgery had longer event-free survival without the cancer coming back and higher rates of substantial tumor shrinkage prior to surgery, according to the first interim analysis of a randomized, open-label phase 3 clinical trial led by investigators from Dana-Farber Brigham Cancer Center and Washington University School of Medicine in St. Louis.

6 May 2025

Neck News and Research

FDA approval of pembrolizumab marks major shift in head and neck cancer treatment

Prenatal exposure to forever chemicals linked to higher teen blood pressure

Study reveals a unique vulnerability in melanoma patients with neurofibromin 1 mutations

New non-invasive method boosts the brain's natural waste drainage system

Navigating the dual role of B cells in tumor immunity

Avelumab and cetuximab combination shows promise in phase II skin cancer trial

Combination treatment extends progression-free survival in advanced skin cancer

TTF1 identified as key biomarker for advanced KRAS G12C-mutated non-small cell lung cancer

New plant-derived therapy shows promise for cancer pain relief

New clinical practice guideline advances surgical care for chronic rhinosinusitis

A ministroke can have major consequences

Vagus nerve stimulation shows unprecedented recovery rates in spinal cord injuries

New blood test detects HPV-linked head and neck cancer with unmatched accuracy

Ubrogepant relieves early migraine symptoms and may help prevent full-blown attacks

Flawed federal programs maroon rural Americans in telehealth blackouts

Hearing aids may help older adults combat social isolation

Millions of women may be unaware of their risk for cardiovascular-kidney-metabolic disease

Annual blood test could detect cancer earlier and save lives

Study identifies key enzyme linked to metastasis in head and neck cancer

Immunotherapy before and after surgery boost longer event-free survival in head and neck cancer

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