Organoids News and Research

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Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.

Engineered fat cells starve tumors and prevent cancer growth

Scientists transformed energy-storing white fat cells into calorie-burning 'beige' fat. Once implanted, they outcompeted tumors for resources, beating back five different types of cancer in lab experiments.

4 Feb 2025

Mayo Clinic researchers create organoid models for uveal melanoma study

Mayo Clinic researchers have developed organoid models to study uveal melanoma, one of the most common types of eye cancer in adults.

29 Jan 2025

New AI software could speed up drug development

The discovery and development of drugs in pharmacological research – including the risk assessment of active substances in the early phase of drug development – still largely relies on animal experiments.

23 Jan 2025

Singapore’s respiratory health gets a boost with $10 million research grant

The Academic Respiratory Initiative for Pulmonary Health (TARIPH) Centre, a national research platform led by Nanyang Technological University, Singapore's (NTU Singapore) Lee Kong Chian School of Medicine (LKCMedicine), will lead a multi-institutional research programme after being awarded Singapore's first national research grant for respiratory health.

23 Jan 2025

New study links intestinal protein to food allergy development

When is food simply nourishing and enjoyable, and when does it provoke an allergic reaction? The answer appears to lie in the balance of microbes that live in our intestine - and a specific protein secreted by intestinal goblet cells that influences that balance.

22 Jan 2025

New air-liquid interface method enhances hair follicle formation in skin organoids

For decades, creating human skin models with physiological relevance has been a persistent challenge in dermatological research.

22 Jan 2025

Exploring the role of confocal-based high-content imaging in advancing core facilities

In this interview, NewsMedical speaks with Esther Kieserman and Arvonn Tully from Yokogawa Life Science about how confocal-based high-content imaging is advancing core facility research and improving data reliability.

From Yokogawa Life Science 20 Jan 2025

Study finds certain H5N1 strains in cattle linked to milder human illness; other variants remain a concern

Study reveals that contemporary HPAI H5N1 viruses show reduced replication and immune activation in human lung organoids, potentially explaining milder disease in humans compared to historic strains.

13 Jan 2025

A large-scale tongue cancer organoid library for precision oncology

Oral cancer is an increasingly prevalent disease worldwide, with over 300,000 new cases diagnosed each year. Among oral cancers, tongue cancer (TC) is the most common type and often carries a poor prognosis. Surgery combined with chemoradiotherapy is one of the main lines of treatment for high-risk cases of TC.

9 Jan 2025

Study finds microRNA target to combat breast cancer treatment resistance

A new University of Cincinnati Cancer Center study has identified a particular strand of microRNA as a promising new target for overcoming breast cancer treatment resistance and improving outcomes.

7 Jan 2025

Researchers grow tumor organoids from blood to tackle breast cancer metastasis

Tumor cells circulating in the blood are the "germ cells" of breast cancer metastases. They are very rare and could not be propagated in the culture dish until now, which made research into therapy resistance difficult.

3 Jan 2025

Yale study identifies molecular mechanism behind some lissencephaly disorders

Lissencephaly is a spectrum of rare, genetic disorders in which the brain fails to develop its hallmark folds.

2 Jan 2025

A scaffolded vaccine approach for broader influenza protection

Most people who get the seasonal influenza vaccine – which contains strains of viruses from distinct virus subtypes – mount a strong immune response to one strain, leaving them vulnerable to infection by the others, and researchers have long wondered what impacts such variable responses more – host genetics or prior exposure to virus strains.

19 Dec 2024

New design could make seasonal influenza vaccinations more broadly effective

Stanford Medicine scientists have designed a way to make our seasonal influenza vaccinations more broadly effective and possibly to protect us from new flu variants with pandemic potential.

19 Dec 2024

Space experiment shows faster maturation of brain organoids in microgravity

Microgravity is known to alter the muscles, bones, the immune system and cognition, but little is known about its specific impact on the brain.

18 Dec 2024

Microbial bile acids affect colon cancer risk in opposite ways

Microbes living in our guts help us digest food by reshaping the bile acids that our livers produce for breaking down fats.

16 Dec 2024

New technique enables laser light to penetrate deeper into living tissues

Metabolic imaging is a noninvasive method that enables clinicians and scientists to study living cells using laser light, which can help them assess disease progression and treatment responses.

11 Dec 2024

Metabolic imaging detects ovarian cancer subtypes and predicts chemotherapy response

Study demonstrates how metabolic imaging differentiates high and low oxidative phosphorylation (OXPHOS) subtypes of high-grade serous ovarian cancer (HGSOC). By assessing metabolic activity, it also identifies early and variable responses to chemotherapy, improving precision in treatment strategies.

10 Dec 2024

Lab-grown tumor organoids predict patient response to CAR T cell therapy

For the first time, researchers used lab-grown organoids created from tumors of individuals with glioblastoma (GBM) to accurately model a patient's response to CAR T cell therapy in real time.

9 Dec 2024

Pregnancy and breastfeeding cause major changes in mothers' intestines

When women are pregnant and nurse their babies, their bodies change and various organs, such as the breasts or the immune system, are adapted to ensure the health of both mother and child.

6 Dec 2024